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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/05/15 10:16:22」(JST)

Cefbuperazone (INN) is a second-generation cephalosporin antibiotic.^[1]^[2]

References

^ Izumi, K.; Kawazoe, K.; Mikamo, H.; Ito, K.; Tamaya, T. (1995). "In vivo bacterial regrowth-inhibition effect of cefbuperazone and amikacin in puerperal uterine cavity". Journal of chemotherapy (Florence, Italy). 7 Suppl 4: 173–176. PMID 8904147. edit
^ US 4754030 "Cefbuperazone crystalline triethylamine salt"

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Pharmacokinetic profile of cefbuperazone in healthy Chinese volunteers after single and multiple drip intravenous infusion by HPLC-MS/MS.

Liu D1, Geng T1, Wang Y2, Ding L3.
Journal of pharmaceutical and biomedical analysis.J Pharm Biomed Anal.2016 Sep 10;129:28-33. doi: 10.1016/j.jpba.2016.06.029. Epub 2016 Jun 23.
A selective and reproducible HPLC-MS/MS method was developed and fully validated for the determination of cefbuperazone in human plasma and urine. Samples were prepared using protein precipitation and separated on a Zorbax Eclipse Plus C18 column (2.1×50mm, 3.5μm). The API-4000 mass spectrometer w
PMID 27394175

Lee KH1, Lim HK1, Park JH1, Do HJ1, Jeon YG1.
Journal of lifestyle medicine.J Lifestyle Med.2015 Mar;5(1):26-9. doi: 10.15280/jlm.2015.5.1.26. Epub 2015 Mar 30.
Although uncommon, anaphylactic reactions during surgery are very dangerous and can result in serious morbidity. Various anesthetics can trigger anaphylactic reactions, and incidents with cephalosporin antibiotics are on the rise. In the case presented, an 84-year-old woman scheduled for calcaneus f
PMID 26528427

(2S,3R)-2-[(4-Ethyl-2,3-dioxopiperazin-1-yl)carbonyl-amino]-3-hydroxy-butyric acid monohydrate.

Ji CX, Cui YT, Yang DL, Guo C.
Acta crystallographica. Section E, Structure reports online.Acta Crystallogr Sect E Struct Rep Online.2008 Jun 19;64(Pt 7):o1292. doi: 10.1107/S1600536808017832.
In the title compound, C(11)H(17)N(3)O(6)·H(2)O, an important building block of the medicine cefbuperazone sodium, the piperazine ring adopts a screw-boat conformation. Inter-molecular O-H⋯O and intra-molecular N-H⋯O hydrogen bonds are observed. The water mol-ecule participates as both donor an
PMID 21202922

Effects of antineoplastics, antibiotics and antidiabetics on acetaldehyde metabolism after alcohol ingestion.

Kan Shin,Moriya Fumio,Ishizu Hideo
Acta Medica Okayama 52(1), 1998-02
… Furthermore, daily administration of cephem antibiotics containing the MTT group, latamoxef, cefamandole, cefoperazone and cefbuperazone, significantly increased blood acetaldehyde concentrations. …
NAID 120002312418

船岡勝博
歯科医学 60(3), g1-g2, 1997-09-25
… このうち阻害効果が検出された抗菌薬は4種 (cefoxitin, cefmetazole, cefbuperazoneおよびlatamoxef)で, 残り5抗菌薬では阻害効果はみられなかった。 …
NAID 110001723281

Decrease in Surface Charge Density of Klebsiella pneumoniae Treated with Cefodizime and Enhancement of the Phagocytic Function of Human Polymorphonuclear Leucocytes Stimulated by the Drug-Treated Bacteria

邨次誠,三宅美行,石田直文,兵頭昭夫,寺山和幸
Biological & pharmaceutical bulletin 18(9), 1259-1263, 1995-09-15
… Treatment of Klebsiella pneumoniae 109 with cefodizime, ceftazidime, cefbuperazone, cefotaxime or flomoxef at a sub-minimum inhibitory concentration (sub-MIC) (1/4 MIC) for 1 h altered its morphology. … pneumoniae, more easily than ceftazidime, cefbuperazone, cefotaxime or flomoxef, followed by an increase in the phagocytic activity of PMNs. …
NAID 110003641034

リンク元	「Hafnia alvei」「セフブペラゾン」
拡張検索	「cefbuperazone sodium」

Cefbuperazone
Systematic (IUPAC) name
	(6R,7S)-7-([(2R,3S)-2-[(4-ethyl-2,3-dioxopiperazine-1-carbonyl)amino]-3-hydroxybutanoyl]amino)-7-methoxy-3-[(1-methyltetrazol-5-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Clinical data
AHFS/Drugs.com	International Drug Names
Legal status	℞ Prescription only
Routes	IM, IV
Identifiers
CAS number	76610-84-9
ATC code	J01DC13
PubChem	CID 127527
ChemSpider	26355342
UNII	T0785J3X40
KEGG	D03423
Chemical data
Formula	C22H29N9O9S2
Mol. mass	627.65 g/mol
	SMILES CCN1CCN(C(=O)C1=O)C(=O)N[C@H]([C@H](C)O)C(=O)N[C@]2([C@@H]3N(C2=O)C(=C(CS3)CSc4nnnn4C)C(=O)O)O;
	InChI InChI=1S/C21H27N9O9S2/c1-4-28-5-6-29(15(34)14(28)33)19(38)22-11(9(2)31)13(32)23-21(39)17(37)30-12(16(35)36)10(7-40-18(21)30)8-41-20-24-25-26-27(20)3/h9,11,18,31,39H,4-8H2,1-3H3,(H,22,38)(H,23,32)(H,35,36)/t9-,11+,18+,21-/m0/s1 ; Key:RMYHXMFWMQQUSC-FATMUFLPSA-N ;
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