カテコラミン受容体、カテコラミンレセプター

WordNet

a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response
any of a group of chemicals including epinephrine and norepinephrine that are produced in the medulla of the adrenal gland

PrepTutorEJDIC

=sense organ / 受信装置

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1. 褐色細胞腫の臨床症状および診断 clinical presentation and diagnosis of pheochromocytoma
2. 心不全におけるアンギオテンシン変換酵素阻害剤およびアンギオテンシン受容体拮抗剤：作用機序 angiotensin converting enzyme inhibitors and receptor blockers in heart failure mechanisms of action
3. 肥満の病因 pathogenesis of obesity
4. 昇圧剤および強心剤の使用 use of vasopressors and inotropes
5. 成人における肥満：薬物療法 obesity in adults drug therapy

English Journal

Nonylphenol effects on the HPA axis of the bioindicator vertebrate, Podarcis sicula lizard.

De Falco M1, Sellitti A2, Sciarrillo R3, Capaldo A2, Valiante S2, Iachetta G2, Forte M2, Laforgia V2.Author information 1Department of Biology, Section of Evolutionary and Comparative Biology, University Federico II of Naples, Via Mezzocannone 8, 80134 Naples, Italy. Electronic address: madefalco@unina.it.2Department of Biology, Section of Evolutionary and Comparative Biology, University Federico II of Naples, Via Mezzocannone 8, 80134 Naples, Italy.3Department of Biological and Environmental Sciences, University of Sannio, Via Port'Arsa 11, 82100 Benevento, Italy.AbstractNonylphenol (NP) is an endocrine disruptor widely distributed in the environment. It accumulates in the lipids of living organisms and enters the human food chain. The main source of human exposure is expected to be food, drinking water and foodstuff contaminated through leaching from packaging or pesticide formulation applications. NP acts as an estrogenic compound and it is able to mimic the action of estradiol 17β (E2) by binding to the estrogen receptor (ER). The aim of the present study was to investigate the NP effects on the hypothalamic-pituitary-adrenal gland (HPA) axis of the bioindicator Podarcis sicula lizard. A time-dependent stimulation of the HPA axis and variations of both catecholamine plasma levels were showed. Moreover, NP effects on adrenal gland morphology were evaluated by light and transmission electron microscopy. Clear morphological signs of adrenal gland stimulation such as an increase of steroidogenic cord diameter and vascularization, a strong escalation of adrenaline cell number and a decrease of noradrenaline cells were observed. The notably elevated levels of adrenal hormones suggested a permanent turning on of hypothalamic corticotropin releasing factor (CRF) secretion together with a lack of the negative feedback of HPA axis, perturbing systemic responses of the organism. Our data may help to predict the biological alterations induced by NP and to extend its impact upon adrenal function.
Chemosphere.Chemosphere.2014 Jun;104:190-6. doi: 10.1016/j.chemosphere.2013.11.014. Epub 2013 Nov 28.
Nonylphenol (NP) is an endocrine disruptor widely distributed in the environment. It accumulates in the lipids of living organisms and enters the human food chain. The main source of human exposure is expected to be food, drinking water and foodstuff contaminated through leaching from packaging or p
PMID 24290296

Prevalence and Prognostic Significance of Long QT Interval in Patients With Acute Coronary Syndrome: Review of the Literature.

Hasanien AA1, Drew BJ, Howie-Esquivel J.Author information 1Amer A. Hasanien, PhD, RN, CNS PhD Graduate, Department of Physiological Nursing, University of California San Francisco, and Assistant Professor, The University of Jordan. Barbara J. Drew, PhD, RN Professor and Director, Critical Care/Trauma Program, Lillian & Dudley Aldous Endowed Chair in Nursing, and Clinical Professor, Division of Cardiology, UCSF School of Medicine. Jill Howie-Esquivel, PhD, RN Assistant Professor, Acute Care Nurse Practitioner Specialty, Department of Physiological Nursing, University of California San Francisco.AbstractBACKGROUND: Sympathetic hyperactivity is linked with several adverse cardiovascular events in patients with acute coronary syndrome (ACS). Sympathetic activity increases early in the process of ischemia through 2 mechanisms. One originates from the central nervous system and leads to enhanced sympathetic activity. The other mechanism originates at the infarct zone and leads to B receptor up-regulation and catecholamine supersensitivity. Nevertheless, sympathetic hyperactivity accompanied by an underlying myocardial structural damage is likely to increase the ventricular repolarization duration measured as QT interval on the body surface electrocardiogram.
The Journal of cardiovascular nursing.J Cardiovasc Nurs.2014 May-Jun;29(3):271-9. doi: 10.1097/JCN.0b013e31829bcf1a.
BACKGROUND: Sympathetic hyperactivity is linked with several adverse cardiovascular events in patients with acute coronary syndrome (ACS). Sympathetic activity increases early in the process of ischemia through 2 mechanisms. One originates from the central nervous system and leads to enhanced sympat
PMID 23839573

Intrinsic vascular dopamine - a key modulator of hypoxia-induced vasodilatation in splanchnic vessels.

Pfeil U1, Kuncova J, Brüggmann D, Paddenberg R, Rafiq A, Henrich M, Weigand MA, Schlüter KD, Mewe M, Middendorff R, Slavikova J, Kummer W.Author information 1Institute for Anatomy and Cell Biology, Justus-Liebig-University, Aulweg 123, 35385 Giessen, Germany. uwe.pfeil@anatomie.med.uni-giessen.de.AbstractDopamine not only is a precursor of the catecholamines noradrenaline and adrenaline but also serves as an independent neurotransmitter and paracrine hormone. It plays an important role in the pathogenesis of hypertension and is a potent vasodilator in many mammalian systemic arteries, strongly suggesting an endogenous source of dopamine in the vascular wall. Here we demonstrated dopamine, noradrenaline and adrenaline in rat aorta and superior mesenteric arteries (SMA) by radioimmunoassay. Chemical sympathectomy with 6-hydroxydopamine showed a significant reduction of noradrenaline and adrenaline, while dopamine levels remained unaffected. Isolated endothelial cells were able to synthesize and release dopamine upon cAMP stimulation. Consistent with these data, mRNAs coding for catecholamine synthesizing enzymes, i.e. tyrosine hydroxylase (TH), aromatic l-amino acid decarboxylase, and dopamine-β-hydroxylase were detected by RT-PCR in cultured endothelial cells from SMA. TH protein was detected by immunohistochemisty and Western blot. Exposure of endothelial cells to hypoxia (1% O2) increased TH mRNA. Vascular smooth muscle cells partially expressed catecholaminergic traits. A physiological role of endogenous vascular dopamine was shown in SMA, where D1 dopamine receptor blockade abrogated hypoxic vasodilatation. Experiments on SMA with endothelial denudation revealed a significant contribution of the endothelium, although subendothelial dopamine release dominated. From these results we conclude that endothelial cells and cells of the underlying vascular wall synthesize and release dopamine in an oxygen-regulated manner. In the splanchnic vasculature, this intrinsic non-neuronal dopamine is the dominating vasodilator released upon lowering of oxygen tension.
The Journal of physiology.J Physiol.2014 Apr 15;592(Pt 8):1745-1756. Epub 2014 Feb 17.
Dopamine not only is a precursor of the catecholamines noradrenaline and adrenaline but also serves as an independent neurotransmitter and paracrine hormone. It plays an important role in the pathogenesis of hypertension and is a potent vasodilator in many mammalian systemic arteries, strongly sugge
PMID 24535440

Japanese Journal

総説 : 自律神経と末梢前庭器 : 末梢前庭系における分子生物学的考察

北原糺
Equilibrium research 71(3), 200-206, 2012-06-01
… Further studies are needed to elucidate the molecular mechanisms in catecholamine and vestibular periphery-mediated vertigo. …
NAID 10030781927

Roles of Heterotrimeric GTP-Binding Proteins in the Progression of Heart Failure

Nishida Motohiro
Journal of pharmacological sciences 117(1), 1-5, 2011-09-20
… The importance of neurohumoral factors, such as angiotensin (Ang) II and catecholamine, for the progression of heart failure has been supported by a variety of evidence. … (Gαq) activates Ca2+-dependent hypertrophic signaling through diacylglycerol-activated transient receptor potential canonical (TRPC) channels (TRPC3 and TRPC6: TRPC3/6). …
NAID 10029895735

Catecholaminergic Polymorphic Ventricular Tachycardia

Leenhardt Antoine
Journal of Arrhythmia 27(Supplement), JSE2, 2011
… CPVT is mostly the result of mutations in genes encoding the cardiac ryanodine receptor Ca2+ … Shocks may trigger catecholamine release, subsequently resulting in arrhythmic storms, multiple shocks, and death. …
NAID 130002129852