WordNet

any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high in protein"
(genetics) a segment of DNA that is involved in producing a polypeptide chain; it can include regions preceding and following the coding DNA as well as introns between the exons; it is considered a unit of heredity; "genes were formerly called factors" (同)cistron, factor
(biology) any agency bringing about activation; a molecule that increases the activity of an enzyme or a protein that increases the production of a gene product in DNA transcription
informal term for information; "give me the gen on your new line of computers"

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Civil Air Patrol民間航空巡視員
蛋白(たんばく)質
遺伝子

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/10/26 18:49:40」(JST)

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cAMP receptor protein (CRP; also known as catabolite activator protein, CAP) is a regulatory protein in bacteria. CRP protein binds cAMP, which causes a conformational change that allows CRP to bind tightly to a specific DNA site in the promoters of the genes it controls.^[1]^[2] CRP then activates transcription through direct protein-protein interactions with RNA polymerase.^[1]^[2]

The genes regulated by CRP are mostly involved in energy metabolism, such as galactose, citrate, or the PEP group translocation system.^[3]^[4] In Escherichia coli, cyclic AMP receptor protein (CRP) can regulate the transcription of more than 100 genes.

The signal to activate CRP is the binding of cyclic AMP. Binding of cAMP to CRP leads to a long-distance signal transduction from the N-terminal cAMP-binding domain to the C-terminal domain of the protein, which is responsible for interaction with specific sequences of DNA.^[5]

At "Class I" CRP-dependent promoters, CRP binds to a DNA site located upstream of core promoter elements and activates transcription through protein-protein interactions between "activating region 1" of CRP and the C-terminal domain of RNA polymerase alpha subunit.^[1]^[2]^[6] At "Class II" CRP-dependent promoters, CRP binds to a DNA site that overlaps the promoter -35 element and activates transcription through two sets of protein-protein interactions: (1) an interaction between "activating region 1" of CRP and the C-terminal domain of RNA polymerase alpha subunit, and (2) an interaction between "activating region 2" of CRP and the N-terminal domain of RNA polymerase alpha subunit.^[1]^[2] At "Class III" CRP-dependent promoters, CRP functions together with one or more "co-activator" proteins.^[1]^[2]

At most CRP-dependent promoters, CRP activates transcription primarily or exclusively through a "recruitment" mechanism, in which protein-protein interactions between CRP and RNA polymerase assist binding of RNA polymerase to the promoter.^[1]

References

^ ^a ^b ^c ^d ^e ^f Busby S., Ebright RH. (1999). "Transcription activation by catabolite activator protein (CAP)". J. Mol. Biol. 293 (2): 199–213. doi:10.1006/jmbi.1999.3161. PMID 10550204.
^ ^a ^b ^c ^d ^e Lawson C.L., Swigon D., Murakami K.S., Darst S.A., Berman H.M., Ebright RH. (2004). "Catabolite activator protein: DNA binding and transcription activation". Curr. Opin. Struct. Biol. 14 (1): 10–20. doi:10.1016/j.sbi.2004.01.012. PMC 2765107. PMID 15102444.
^ Weickert MJ, Adhya S (1993). "The galactose regulon of Escherichia coli". Mol. Microbiol. 10 (2): 245–51. doi:10.1111/j.1365-2958.1993.tb01950.x. PMID 7934815.
^ Bott M (1997). "Anaerobic citrate metabolism and its regulation in enterobacteria". Arch. Microbiol. 167 (2–3): 78–88. doi:10.1007/s002030050419. PMID 9133329.
^ Popovych, N.; Tzeng, S. -R.; Tonelli, M.; Ebright, R. H.; Kalodimos, C. G. (2009). "Structural basis for cAMP-mediated allosteric control of the catabolite activator protein". Proceedings of the National Academy of Sciences 106 (17): 6927–6932. doi:10.1073/pnas.0900595106. PMC 2678429. PMID 19359484.
^ Hudson, B. P.; Quispe, J.; Lara-Gonzalez, S.; Kim, Y.; Berman, H. M.; Arnold, E.; Ebright, R. H.; Lawson, C. L. (2009). "Three-dimensional EM structure of an intact activator-dependent transcription initiation complex". Proceedings of the National Academy of Sciences 106 (47): 19830–19835. doi:10.1073/pnas.0908782106. PMC 2775702. PMID 19903881.

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Dopamine-sensitive signaling mediators modulate psychostimulant-induced ultrasonic vocalization behavior in rats.

Williams SN1, Undieh AS2.
Behavioural brain research.Behav Brain Res.2016 Jan 1;296:1-6. doi: 10.1016/j.bbr.2015.08.008. Epub 2015 Aug 11.
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Differentiation-Coupled Induction of Human Cytomegalovirus Replication by Union of the Major Enhancer Retinoic Acid, Cyclic AMP, and NF-κB Response Elements.

Yuan J1, Li M1, Torres YR1, Galle CS1, Meier JL2.
Journal of virology.J Virol.2015 Dec 15;89(24):12284-98. doi: 10.1128/JVI.00965-15. Epub 2015 Sep 30.
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Lysine Acetylation of CREBH Regulates Fasting-Induced Hepatic Lipid Metabolism.

Kim H1, Mendez R1, Chen X2, Fang D3, Zhang K4.
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Japanese Journal

Decrease in Expression of the Master Operon of Flagellin Synthesis in a dnaA46 Mutant of Escherichia coli

Mizushima Tohru,Koyanagi Rimiko,Katayama Tsutomu [他],MIKI Takeyoshi,SEKIMIZU Kazuhisa
Biological & pharmaceutical bulletin 20(4), 327-331, 1997-04-15
… The promoter activity of each gene also decreased in this mutant at 37℃, but not at 28℃. … The decrease in expression of the flhD gene was not related to the cAMP-catabolite activator protein (CAP) pathway. … We tentatively conclude that DnaA protein is involved in the expression of the flhD gene by a mechanism independent of the cAMP-CAP pathway. …
NAID 110003639050

オペロン説にもとずく遺伝子調節の動特性にたいする工学的数値計算解析

平山博史,後藤新太郎,吉井清乃,尾島英知,河合憲一,福山裕三
電子情報通信学会技術研究報告. MBE, MEとバイオサイバネティックス 94(100), 63-70, 1994-06-17
… さらに、cAMP-Catabolite蛋白複合体によるプロモーター遺伝子部の活性増強作用を考慮してかれらの提唱したモデルを非線形微分方程式であらわしこれらを数値解法で解をもとめそれぞれの因子に過渡的変化を解析した。 …
NAID 110003287379

Consensus DNA site for the Escherichia coli catabolite gene activator protein (CAP) : CAP exhibits a 450-fold higher affinity for the consensus DNA site than for the E. coli lac DNA site

EBRIGHT R.
Nucleic Acids Res. 17, 10295-10305, 1989
NAID 80004966793

Related Pictures

★リンクテーブル★

リンク元	「サイクリックAMP受容蛋白質」「カタボライト・アクチベータ・プロテイン」「cyclic AMP regulatory protein」
関連記事	「activator」「catabolite」「activator protein」

「サイクリックAMP受容蛋白質」

CAMP receptor protein
	Structure of the E. coli Cyclic AMP Receptor Protein.
Identifiers
Symbol	CRP
Alt. symbols	CAP
Entrez	947867
PDB	1I5Z
RefSeq	NP_417816.1
UniProt	P0ACJ8