cassette mutagenesis

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insertional activationinsertional mutagenesis

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/02/03 18:39:55」(JST)

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  • Cytological characterization of murine bone marrow and spleen hematopoietic compartments for improved assessment of toxicity in preclinical gene marking models.
  • Yang M, Büsche G, Ganser A, Li Z.SourceInstitute of Experimental Hematology, OE6960, Hannover Medical School, Carl-Neuberg-Straße 1, 30625, Hannover, Germany.
  • Annals of hematology.Ann Hematol.2013 May;92(5):595-604. doi: 10.1007/s00277-012-1655-3. Epub 2013 Jan 10.
  • Gene therapy has proven its potential to cure diseases of the hematopoietic system, but potential adverse reactions related to insertional mutagenesis by integrating gene vectors and chromosomal instability in long-lived repopulating cells have emerged as a major limitation. Preclinical gene therapy
  • PMID 23307598
  • Protein contacts and ligand binding in the inward-facing model of human p-glycoprotein.
  • Pajeva IK, Hanl M, Wiese M.SourceInstitute of Biophysics and Biomedical Engineering, Bulgarian Academy of Sciences, Acad. G. Bonchev Str., Bl. 105, 1113 Sofia (Bulgaria).
  • ChemMedChem.ChemMedChem.2013 May;8(5):748-62. doi: 10.1002/cmdc.201200491. Epub 2013 Apr 5.
  • The primary aim of this work was to analyze the contacts between residues in the nucleotide binding domains (NBDs) and at the interface between the transmembrane domains (TMDs) and the NBDs in the inward-open homology model of human P-glycoprotein (P-gp). The analysis revealed communication nets thr
  • PMID 23564544
  • Genome-wide association study of sleep in Drosophila melanogaster.
  • Harbison ST, McCoy LJ, Mackay TF.AbstractBACKGROUND: Sleep is a highly conserved behavior, yet its duration and pattern vary extensively among species and between individuals within species. The genetic basis of natural variation in sleep remains unknown.
  • BMC genomics.BMC Genomics.2013 Apr 25;14(1):281. [Epub ahead of print]
  • BACKGROUND: Sleep is a highly conserved behavior, yet its duration and pattern vary extensively among species and between individuals within species. The genetic basis of natural variation in sleep remains unknown.RESULTS: We used the Drosophila Genetic Reference Panel (DGRP) to perform a genome-wid
  • PMID 23617951


  • トランスポゾンに基づく持続発現型ベクターの開発と治療応用
  • 中西 秀之,樋口 ゆり子,川上 茂 [他],山下 富義,橋田 充
  • YAKUGAKU ZASSHI 129(12), 1433-1443, 2009
  • … One is the transposon containing transgenes, and the other is the expression cassette of the transposase. … Although transposon-based integrative vector systems have problems, such as insertional mutagenesis, studies to overcome these problems have been progressing, and these vector systems will become indispensable tools to cure refractory diseases. …
  • NAID 130000136134
  • Quinoprotein Alcohol Dehydrogenase Is Involved in Catabolic Acetate Production, while NAD-Dependent Alcohol Dehydrogenase in Ethanol Assimilation in Acetobacter pasteurianus SKU1108(MICROBIAL PHYSIOLOGY AND BIOTECHNOLOGY)
  • Chinnawirotpisan Piyawan,Theeragool Gunjana,Limtong Savitree [他],TOYAMA HIROHIDE,ADACHI OSAO,MATSUSHITA KAZUNOBU
  • Journal of bioscience and bioengineering 96(6), 564-571, 2003-12-25
  • … Quinoprotein ADH-deficient mutants were successfully constructed from Acetobacterpasteurianus SKU1108 by N-methyl-N'-nitro-N-nitrosoguanidine (NTG) mutagenesis and also by adhA gene disruption with a kana mycin cassette. …
  • NAID 110002665243
  • Identification of three key residues in substrate recognition site 5 of human cytochrome P450 3A4 by cassette and site-directed mutagenesis


Cassette mutagenesis involves replacing a wild-type DNA sequence with synthetic double-stranded oligonucleotides in order to introduce one or more mutations (1-6). The technique allows saturation of a target amino acid codon with ...
1. Gene. 1985;34(2-3):315-23. Cassette mutagenesis: an efficient method for generation of multiple mutations at defined sites. Wells JA, Vasser M, Powers DB. A method is described for the efficient insertion of mutagenic ...


The Amino Acid at the X Position of an Asn Insertional mutagenesis basedFigure 6.37. Cassette Mutagenesis.Cassette Mutagenesis [ edit ]Cassette MutagenesisControlling the enantioselectivity of

リンク元カセット変異導入法」「insertional activation」「insertional mutagenesis」「カセット変異導入



cassette mutagenesis

insertional activation」



cassette mutagenesisinsertional mutagenesis

insertional mutagenesis」


cassette mutagenesisinsertional activation



cassette mutagenesis



WordNet   license wordnet

「a container that holds a magnetic tape used for recording or playing sound or video」

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  [★] 変異原性


WordNet   license wordnet

「an event capable of causing a mutation」