WordNet

(geology) amass of fine-grained rock in which fossils, crystals, or gems are embedded
mold used in the production of phonograph records, type, or other relief surface
the body substance in which tissue cells are embedded (同)intercellular substance, ground_substance
(mathematics) a rectangular array of quantities or expressions set out by rows and columns; treated as a single element and manipulated according to rules
an enclosure within which something originates or develops (from the Latin for womb)
the formative tissue at the base of a nail
any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high in protein"
tough elastic tissue; mostly converted to bone in adults (同)gristle

PrepTutorEJDIC

（複数形 matrices, ～・es）(発生・成長の)母体 / 鋳型・模型;(レコードの)原盤;(活字の)母型,字母 / (金属・化石・宝石などの含んだ)母岩・《古》子宮・基盤; (細胞)細胞間質; (地学)基質; (印)字母; 紙型; 鋳型; (鉱)母岩; (数)行列; (コンピュータ)マトリックス (入力導線と出力導線の回路網); (言)母型文（matrix sentence）
蛋白(たんばく)質
軟骨[組織]
マトリクシング(4チャンネルに再生転換できる2チャンネルの録音方式)

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/02/19 15:17:19」(JST)

wiki en

Cartilage oligomeric matrix protein (COMP), also known as thrombospondin-5, is an extracellular matrix (ECM) protein primarily present in cartilage. In humans it is encoded by the COMP gene.^[1]^[2]^[3]

Function

The protein encoded by this gene is a noncollagenous extracellular matrix (ECM) protein.^[4] It consists of five identical glycoprotein subunits, each with EGF-like and calcium-binding (thrombospondin-like) domains. Oligomerization results from formation of a five-stranded coiled coil and disulfide bonds. Binding to other ECM proteins such as collagen appears to depend on divalent cations. Mutations can cause the osteochondrodysplasias pseudoachondroplasia (PSACH) and multiple epiphyseal dysplasia (MED).^[3]

COMP is a marker of cartilage turnover.^[5] It is present in high quantities in fibrotic scars and systemic sclerosis, and it appears to have a role in vascular wall remodeling.^[6]

References

^ Newton G, Weremowicz S, Morton CC, Copeland NG, Gilbert DJ, Jenkins NA, Lawler J (Dec 1994). "Characterization of human and mouse cartilage oligomeric matrix protein". Genomics 24 (3): 435–9. doi:10.1006/geno.1994.1649. PMID 7713493.
^ Briggs MD, Rasmussen IM, Weber JL, Yuen J, Reinker K, Garber AP, Rimoin DL, Cohn DH (Dec 1993). "Genetic linkage of mild pseudoachondroplasia (PSACH) to markers in the pericentromeric region of chromosome 19". Genomics 18 (3): 656–60. doi:10.1016/S0888-7543(05)80369-6. PMID 8307576.
^ ^a ^b "Entrez Gene: COMP cartilage oligomeric matrix protein".
^ Paulsson M, Heinegård D (Aug 1981). "Purification and structural characterization of a cartilage matrix protein". The Biochemical Journal 197 (2): 367–75. PMC 1163135. PMID 7325960.
^ Petersen SG, Saxne T, Heinegard D, Hansen M, Holm L, Koskinen S, Stordal C, Christensen H, Aagaard P, Kjaer M (Jan 2010). "Glucosamine but not ibuprofen alters cartilage turnover in osteoarthritis patients in response to physical training". Osteoarthritis and Cartilage / OARS, Osteoarthritis Research Society 18 (1): 34–40. doi:10.1016/j.joca.2009.07.004. PMID 19679221.
^ Halper J, Kjaer M (2014). "Basic components of connective tissues and extracellular matrix: elastin, fibrillin, fibulins, fibrinogen, fibronectin, laminin, tenascins and thrombospondins". Advances in Experimental Medicine and Biology 802: 31–47. doi:10.1007/978-94-007-7893-1_3. PMID 24443019.

External links

GeneReviews/NCBI/NIH/UW entry on Pseudoachondroplasia
GeneReviews/NCBI/NIH/UW entry on Multiple Epiphyseal Dysplasia, Dominant
cartilage matrix protein at the US National Library of Medicine Medical Subject Headings (MeSH)

This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by expanding it.

UpToDate Contents

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1. 研究用生物学的マーカーによる関節リウマチの診断および評価ま investigational biologic markers in the diagnosis and assessment of rheumatoid arthritis
2. 再発性多発性軟骨炎の診断的評価 diagnostic evaluation of relapsing polychondritis
3. 関節リウマチの診断および評価における生物学的マーカー biologic markers in the diagnosis and assessment of rheumatoid arthritis
4. 止血の概要 overview of hemostasis

English Journal

Cartilage oligomeric matrix protein (COMP) in murine brachiocephalic and carotid atherosclerotic lesions.

Bond AR1, Hultgårdh-Nilsson A2, Knutsson A3, Jackson CL4, Rauch U5.
Atherosclerosis.Atherosclerosis.2014 Oct;236(2):366-72. doi: 10.1016/j.atherosclerosis.2014.07.029. Epub 2014 Aug 5.
OBJECTIVE: To investigate the hypothesis that COMP can influence the morphology, stability and size of murine atherosclerotic lesions.METHODS: ApoE- and ApoE/COMP-knockout mice were fed a high-fat diet to develop atherosclerotic plaques at lesion sites of three different types; inflammatory and fibr
PMID 25133350

Biochemical markers of joint tissue damage increase shortly after a joint bleed; an explorative human and canine in vivo study.

van Vulpen LF1, van Meegeren ME2, Roosendaal G3, Jansen NW4, van Laar JM5, Schutgens RE6, Mastbergen SC7, Lafeber FP8.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society.Osteoarthritis Cartilage.2014 Sep 16. pii: S1063-4584(14)01254-0. doi: 10.1016/j.joca.2014.09.008. [Epub ahead of print]
OBJECTIVE: Evaluation whether biomarkers of joint damage are sensitive to change shortly after a joint bleed in hemophilia patients and in a canine model of blood-induced joint damage.METHODS: Blood and urine samples were collected from 10 hemophilia patients after they reported a joint bleed: withi
PMID 25219667

Extracellular Matrix and Developing Growth Plate.

Myllyharju J.
Current osteoporosis reports.Curr Osteoporos Rep.2014 Sep 12. [Epub ahead of print]
Growth plate is a specialized cartilaginous structure that mediates the longitudinal growth of skeletal bones. It consists of ordered zones of chondrocytes that secrete an extracellular matrix (ECM) composed of specific types of collagens and proteoglycans. Several heritable human skeletal dysplasia
PMID 25212565

Japanese Journal

Three Dimensional Spheroid Culture of Canine Amniotic Fluid Derived Mesenchymal Stem Cells Enhances Differentiation Efficacycy

Journal of the Faculty of Agriculture, Kyushu University 60(2), 377-384, 2015-09-18
NAID 120005661372

Culture temperature affects redifferentiation and cartilaginous extracellular matrix formation in dedifferentiated human chondrocytes.

Journal of orthopaedic research 33(5), 633-639, 2015-03-05
NAID 120005663299

The combined effects of iguratimod with anti-TNFα antibody on experimental arthritis models in mice

Inflammation and Regeneration 34(3), 157-164, 2014
NAID 130004943861

Related Pictures

★リンクテーブル★

リンク元	「軟骨オリゴマー基質タンパク質」「COMP」
関連記事	「matrix protein」「oligomeric」「oligomer」

「軟骨オリゴマー基質タンパク質」

Cartilage oligomeric matrix protein
	PDB rendering based on 1fbm.
Available structures
PDB	Ortholog search: PDBe, RCSB
List of PDB id codes
	3FBY
Identifiers
Symbols	COMP ; EDM1; EPD1; MED; PSACH; THBS5
External IDs	OMIM: 600310 MGI: 88469 HomoloGene: 74 GeneCards: COMP Gene
Gene ontology
Molecular function	• protease binding; • extracellular matrix structural constituent; • calcium ion binding; • protein binding; • collagen binding; • heparin binding; • heparan sulfate proteoglycan binding;
Cellular component	• extracellular region; • proteinaceous extracellular matrix; • extracellular space; • extracellular matrix; • extracellular exosome;
Biological process	• skeletal system development; • growth plate cartilage development; • apoptotic process; • cell adhesion; • organ morphogenesis; • extracellular matrix organization; • negative regulation of apoptotic process; • limb development;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
	v; t; e;