WordNet

any of several fat-soluble organic compounds having as a basis 17 carbon atoms in four rings; many have important physiological effects

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1. ステロイドの中断 glucocorticoid withdrawal
2. ステロイドの全身投与の主な副作用 major side effects of systemic glucocorticoids
3. ステロイドの薬理学的使用 pharmacologic use of glucocorticoids
4. 早産による新生児の罹病および死亡を減少させるための出産前ステロイド療法 antenatal corticosteroid therapy for reduction of neonatal morbidity and mortality from preterm delivery
5. 全身性ステロイドに対する過敏反応 hypersensitivity reactions to systemic glucocorticoids

Cytotoxicity of cardiotonic steroids in sensitive and multidrug-resistant leukemia cells and the link with Na(+)/K(+)-ATPase.

Zeino M1, Brenk R2, Gruber L1, Zehl M3, Urban E4, Kopp B5, Efferth T6.
The Journal of steroid biochemistry and molecular biology.J Steroid Biochem Mol Biol.2015 Jun;150:97-111. doi: 10.1016/j.jsbmb.2015.03.008. Epub 2015 Mar 19.
Cardiotonic steroids have long been in clinical use for treatment of heart failure and are now emerging as promising agents in various diseases, especially cancer. Their main target is Na(+)/K(+)-ATPase, a membrane protein involved in cellular ion homeostasis. Na(+)/K(+)-ATPase has been implicated i
PMID 25797029

Hamlyn JM1, Manunta P2.
Advances in chronic kidney disease.Adv Chronic Kidney Dis.2015 May;22(3):232-244. doi: 10.1053/j.ackd.2014.12.005.
In response to progressive nephron loss, volume and humoral signals in the circulation have increasing relevance. These signals, including plasma sodium, angiotensin II, and those related to volume status, activate a slow neuromodulatory pathway within the central nervous system (CNS). The slow CNS
PMID 25908473

Cardiotonic steroid ouabain stimulates expression of blood-testis barrier proteins claudin-1 and -11 and formation of tight junctions in Sertoli cells.

Dietze R1, Shihan M1, Stammler A2, Konrad L3, Scheiner-Bobis G4.
Molecular and cellular endocrinology.Mol Cell Endocrinol.2015 Apr 15;405:1-13. doi: 10.1016/j.mce.2015.02.004. Epub 2015 Feb 7.
The interaction of ouabain with the sodium pump induces signalling cascades resembling those triggered by hormone/receptor interactions. In the rat Sertoli cell line 93RS2, ouabain at low concentrations stimulates the c-Src/c-Raf/Erk1/2 signalling cascade via its interaction with the α4 isoform of
PMID 25666991

Analyses of Biologically Active Steroids: Antitumor Active OSW-1 and Cardiotonic Marinobufotoxin, by Matrix-Assisted Laser Desorption/Ionization Quadrupole Ion Trap Time-of-Flight Tandem Mass Spectrometry

Kasai Hiroko,Tsubuki Masayoshi,Shimada Kazutake [他],Nambara Toshio,Honda Toshio
Chemical and Pharmaceutical Bulletin 57(9), 948-956, 2009
… In this study, matrix-assisted laser desorption/ionization (MALDI) quadrupole ion trap (QIT) time-of-flight tandem mass spectrometry (TOF-MSn) was used to identify both OSW-1, an acetylated cholestane diglycoside showing antitumor activity, and the cardiotonic steroid, bufotoxin. … On MALDI-TOF-MS, sodium-adduct [M+Na]+ ions were observed in the steroid glycosides, although protonated [M+H]+ ions were relatively more abundant than sodium-adduct [M+Na]+ ions in the bufotoxins. …
NAID 130000124190

Studies on Cardiac Ingredients of Plants. XIII : Chemical Modification of Gitoxin to Cardiotonic Compounds without Vascular Contractile Effect

Nagatsu Akito,Nakamura Yukitaka,Takemoto Kouya [他],SHIBATOMI Kazutaka,NAGAI Shin-ichi,UEDA Taisei,SAKAKIBARA Jinsaku,HIDAKA Hiroyoshi,FUJITA Michiko,HOTTA Yoshihiro,TAKEYA Kazumi,ASANO Masahisa,HASHIMOTO Toshihiro,ASAKAWA Yoshinori
Chemical & pharmaceutical bulletin 45(4), 599-607, 1997-04-15
… Nitrated gitoxins (4) and bufotoxin homologues with various lengths of alkyl chain at C-3 of the steroid nucleus (10) were prepared from gitoxin (1). …
NAID 110003616536