カルブタミド
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/12/12 00:36:44」(JST)
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Carbutamide
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| Systematic (IUPAC) name |
|
4-amino-N-(butylcarbamoyl)benzenesulfonamide
|
| Clinical data |
| AHFS/Drugs.com |
International Drug Names |
Routes of
administration |
Oral |
| Identifiers |
| CAS Number |
339-43-5 Y |
| ATC code |
A10BB06 |
| PubChem |
CID: 9564 |
| ChemSpider |
9189 N |
| UNII |
E3K8P4869P Y |
| ChEMBL |
CHEMBL448570 Y |
| Chemical data |
| Formula |
C11H17N3O3S |
| Molecular mass |
271.335 g/mol |
SMILES
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O=S(=O)(c1ccc(N)cc1)NC(=O)NCCCC
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InChI
-
InChI=1S/C11H17N3O3S/c1-2-3-8-13-11(15)14-18(16,17)10-6-4-9(12)5-7-10/h4-7H,2-3,8,12H2,1H3,(H2,13,14,15) N
-
Key:VDTNNGKXZGSZIP-UHFFFAOYSA-N N
|
| N (what is this?) (verify) |
Carbutamide (brand name Glucidoral) is an anti-diabetic drug of the sulfonylurea class, developed by Servier.
It is classified as first-generation.[1]
References
- ^ Ballagi-Pordány G, Köszeghy A, Koltai MZ, Aranyi Z, Pogátsa G (January 1990). "Divergent cardiac effects of the first and second generation hypoglycemic sulfonylurea compounds". Diabetes Res. Clin. Pract. 8 (2): 109–14. doi:10.1016/0168-8227(90)90020-T. PMID 2106423.
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Oral anti-diabetic drugs and Insulin analogs (A10)
|
|
| Insulin |
| Sensitizers |
| Biguanides |
- Metformin#
- Buformin‡
- Phenformin‡
|
|
| TZDs/"glitazones" (PPAR) |
- Ciglitazone§
- Darglitazone§
- Englitazone§
- Lobeglitazone
- Netoglitazone§
- Pioglitazone
- Rivoglitazone†
- Rosiglitazone
- Troglitazone‡
|
|
| Dual PPAR agonists |
- Aleglitazar†
- Muraglitazar§
- Saroglitazar
- Tesaglitazar§
|
|
|
| Secretagogues |
| K+ ATP |
| Sulfonylureas |
- 1st generation: Acetohexamide
- Carbutamide
- Chlorpropamide
- Metahexamide
- Tolbutamide
- Tolazamide
- 2nd generation: Glibenclamide (Glyburide)#
- Glibornuride
- Glipizide
- Gliquidone
- Glisoxepide
- Glyclopyramide
- Glimepiride
- Gliclazide
|
|
| Meglitinides/"glinides" |
- Nateglinide
- Repaglinide
- Mitiglinide
|
|
|
| GLP-1 agonists |
- Exenatide
- Liraglutide
- Taspoglutide†
- Albiglutide†
- Lixisenatide
- Dulaglutide
- Semaglutide
|
|
| DPP-4 inhibitors |
- Alogliptin
- Anagliptin
- Gemigliptin
- Linagliptin
- Omarigliptin
- Saxagliptin
- Sitagliptin
- Teneligliptin
- Vildagliptin
|
|
| GPR40 Free fatty acid receptor 1 |
|
|
|
| Analogs/other insulins |
- fast-acting (Insulin lispro
- Insulin aspart
- Insulin glulisine)
- short-acting (Regular insulin)
- long-acting (Insulin glargine
- Insulin detemir
- NPH insulin)
- ultra-long-acting (Insulin degludec†)
- inhalable Exubera‡
- Afrezza
|
|
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| Other |
| Alpha-glucosidase inhibitors |
- Acarbose
- Miglitol
- Voglibose
|
|
| Amylin analog |
|
|
| Gliflozins |
- Canagliflozin
- Dapagliflozin
- Empagliflozin
- Remogliflozin§
- Sergliflozin§
- Tofogliflozin†
|
|
| Other |
- Bromocriptine
- Benfluorex‡
- Tolrestat‡
|
|
|
-
- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
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|
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Index of hormones
|
|
| Description |
- Glands
- Hormones
- thyroid
- mineralocorticoids
- Physiology
- Development
|
|
| Disease |
- Diabetes
- Congenital
- Neoplasms and cancer
- Other
- Symptoms and signs
|
|
| Treatment |
- Procedures
- Drugs
- calcium balance
- corticosteroids
- oral hypoglycemics
- pituitary and hypothalamic
- thyroid
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|
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English Journal
- Study on the interactions of sulfonylurea antidiabetic drugs with normal and glycated human serum albumin by capillary electrophoresis-frontal analysis.
- Michalcová L1, Glatz Z2.
- Journal of separation science.J Sep Sci.2016 Sep;39(18):3631-7. doi: 10.1002/jssc.201600713. Epub 2016 Aug 24.
- PMID 27449705
- Identification and quantification of 8 sulfonylureas with clinical toxicology interest by liquid chromatography-ion-trap tandem mass spectrometry and library searching.
- Hoizey G1, Lamiable D, Trenque T, Robinet A, Binet L, Kaltenbach ML, Havet S, Millart H.
- Clinical chemistry.Clin Chem.2005 Sep;51(9):1666-72. Epub 2005 Jul 14.
- PMID 16020498
- History of diabetes mellitus.
- Ahmed AM1.
- Saudi medical journal.Saudi Med J.2002 Apr;23(4):373-8.
- PMID 11953758
Japanese Journal
- 正常及びアロキサン糖尿病家兎におけるカルブタミドの血清蛋白結合
- Effect of Simultaneous Administration of Drugs on Absorption and Excretion. XIII. Effect of Salicylic Acid on the Absorption, Distribution and Elimination of Carbutamide in Rabbits
- Effect of Simultaneous Administration of Drugs on Absorption and Excretion. XII. Effect of Salicylic Acid on Hypoglycemic Activity and Blood Concentration of Carbutamide in Rabbits
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