同: CAII

WordNet

an abundant nonmetallic tetravalent element occurring in three allotropic forms: amorphous carbon and graphite and diamond; occurs in all organic compounds (同)C, atomic number 6
a copy made with carbon paper (同)carbon_copy
the 9th letter of the Roman alphabet (同)i

PrepTutorEJDIC

『炭素』(化学記号は『C』) / 〈C〉炭素棒 / 〈C〉《時に〈U〉》=carbon paper
『私は』私が
iodineの化学記号

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/06/13 22:40:15」(JST)

wiki en

Carbonic anhydrase II (gene name CA2), is one of fourteen forms of human α carbonic anhydrases. Carbonic anhydrase catalyzes reversible hydration of carbon dioxide. Defects in this enzyme are associated with osteopetrosis and renal tubular acidosis. Renal carbonic anhydrase allows the reabsorption of bicarbonate ions in the proximal tubule. ^[1]

Interactions

Carbonic anhydrase II has been shown to interact with Band 3^[2]^[3]^[4]^[5] and Sodium-hydrogen antiporter 1.^[6]

References

^ "Entrez Gene: CA2 carbonic anhydrase II".
^ Sterling, D; Reithmeier R A; Casey J R (December 2001). "A transport metabolon. Functional interaction of carbonic anhydrase II and chloride/bicarbonate exchangers". J. Biol. Chem. (United States) 276 (51): 47886–94. doi:10.1074/jbc.M105959200. ISSN 0021-9258. PMID 11606574.
^ Vince, J W; Reithmeier R A (October 1998). "Carbonic anhydrase II binds to the carboxyl terminus of human band 3, the erythrocyte C1-/HCO3- exchanger". J. Biol. Chem. (UNITED STATES) 273 (43): 28430–7. doi:10.1074/jbc.273.43.28430. ISSN 0021-9258. PMID 9774471.
^ Vince, J W; Carlsson U; Reithmeier R A (November 2000). "Localization of the Cl-/HCO3- anion exchanger binding site to the amino-terminal region of carbonic anhydrase II". Biochemistry (UNITED STATES) 39 (44): 13344–9. doi:10.1021/bi0015111. ISSN 0006-2960. PMID 11063570.
^ Vince, J W; Reithmeier R A (May 2000). "Identification of the carbonic anhydrase II binding site in the Cl(-)/HCO(3)(-) anion exchanger AE1". Biochemistry (UNITED STATES) 39 (18): 5527–33. doi:10.1021/bi992564p. ISSN 0006-2960. PMID 10820026.
^ Li, Xiuju; Alvarez Bernardo; Casey Joseph R; Reithmeier Reinhart A F; Fliegel Larry (September 2002). "Carbonic anhydrase II binds to and enhances activity of the Na+/H+ exchanger". J. Biol. Chem. (United States) 277 (39): 36085–91. doi:10.1074/jbc.M111952200. ISSN 0021-9258. PMID 12138085.

UpToDate Contents

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1. 幼児および小児における尿細管性アシドーシスの病因および臨床症状 etiology and clinical manifestations of renal tubular acidosis in infants and children
2. シェーグレン症候群における腎疾患 renal disease in sjogrens syndrome
3. 腎尿細管性アシドーシスの病態生理およびカリウムバランスへの影響 pathophysiology of renal tubular acidosis and the effect on potassium balance
4. 遠位（I型）および近位（II型）尿細管性アシドーシスの病因および診断 etiology and diagnosis of distal type 1 and proximal type 2 renal tubular acidosis
5. 尿細管性アシドーシスの概要 overview of renal tubular acidosis

English Journal

PMID 24913698

New aromatic/heteroaromatic propanesulfonylhydrazone compounds: synthesis, physical properties and inhibition studies against carbonic anhydrase II (CAII) enzyme.

Özmen Özdemir Ü1, Altuntaş A2, Gündüzalp AB2, Arslan F2, Hamurcu F3.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.Spectrochim Acta A Mol Biomol Spectrosc.2014 Jul 15;128:452-60. doi: 10.1016/j.saa.2014.02.049. Epub 2014 Feb 25.
Some new aromatic/heteroaromatic propanesulfonylhydrazone derivatives (1-8) were synthesized and characterized by elemental analyses, FT-IR, (1)H NMR, (13)C NMR, LC/MS techniques. The geometry optimizations and spectral calculations were performed by using DFT/B3LYP/6-311G(d,p) basis set in Gaussian
PMID 24682061

Oxidation of cyanobenzocycloheptatrienes: Synthesis, photooxygenation reaction and carbonic anhydrase isoenzymes inhibition properties of some new benzotropone derivatives.

Güney M1, Coşkun A2, Topal F3, Daştan A4, Gülçin I5, Supuran CT6.
Bioorganic & medicinal chemistry.Bioorg Med Chem.2014 Jul 1;22(13):3537-43. doi: 10.1016/j.bmc.2014.04.007. Epub 2014 May 2.
The oxidation of some cyanocycloheptatrienes with CrO3 and pyridine was investigated and a few new nitrile functionalised benzotropone derivatives were obtained. Photooxygenation reaction of these products was also studied. The structures of the formed products were determined on the basis of NMR sp
PMID 24856184

Japanese Journal

Purely Endoscopic Repair of Traumatic Cerebrospinal Fluid Rhinorrhea From the Anterior Skull Base : —Case Report—

KOMATSU Mika,KOMATSU Fuminari,CAVALLO Luigi M.,SOLARI Domenico,STAGNO Vita,INOUE Tooru,CAPPABIANCA Paolo
Neurologia medico-chirurgica 51(3), 222-225, 2011
… After conservative medical treatment with carbonic anhydrase inhibitors failed, she was referred to our hospital for surgical repair of the osteodural defect. … Recovery is often spontaneous following only bed rest, or with medical treatments such as inhibitors of carbonic anhydrase diuretics, steroids, or eventually stool softeners to help reduce CSF pressure. …
NAID 130000677032

Timolol Activates the Enzyme Activities of Human Carbonic Anhydrase I and II

Sugimoto Ayako,Ikeda Hiroaki,Tsukamoto Hidetoshi,Kihira Kenji,Ishioka Manabu,Hirose Junzo,Hata Toshiyuki,Fujioka Haruto,Ono Yukio
Biological & Pharmaceutical Bulletin 33(2), 301-306, 2010
… Timolol, a beta-blocker, has been shown to be an effective ocular hypotensive agent when used alone or with carbonic anhydrase inhibitor on ocular hypertensive or open angle glaucoma patients. … The effect of timolol hemihydrate on the CO2 hydration activities of human carbonic anhydrase (HCA) I and II and their reaction mechanisms were investigated. … Timolol activates the enzyme activities of HCA I and HCA II. …
NAID 130000156641

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関連記事	「II」「I」「carbonic」「anhydrase」「carbon」

「II」

CA2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	12CA, 1A42, 1AM6, 1AVN, 1BCD, 1BIC, 1BN1, 1BN3, 1BN4, 1BNM, 1BNN, 1BNQ, 1BNT, 1BNU, 1BNV, 1BNW, 1BV3, 1CA2, 1CA3, 1CAH, 1CAI, 1CAJ, 1CAK, 1CAL, 1CAM, 1CAN, 1CAO, 1CAY, 1CAZ, 1CCS, 1CCT, 1CCU, 1CIL, 1CIM, 1CIN, 1CNB, 1CNC, 1CNG, 1CNH, 1CNI, 1CNJ, 1CNK, 1CNW, 1CNX, 1CNY, 1CRA, 1CVA, 1CVB, 1CVC, 1CVD, 1CVE, 1CVF, 1CVH, 1DCA, 1DCB, 1EOU, 1F2W, 1FQL, 1FQM, 1FQN, 1FQR, 1FR4, 1FR7, 1FSN, 1FSQ, 1FSR, 1G0E, 1G0F, 1G1D, 1G3Z, 1G45, 1G46, 1G48, 1G4J, 1G4O, 1G52, 1G53, 1G54, 1H4N, 1H9N, 1H9Q, 1HCA, 1HEA, 1HEB, 1HEC, 1HED, 1HVA, 1I8Z, 1I90, 1I91, 1I9L, 1I9M, 1I9N, 1I9O, 1I9P, 1I9Q, 1IF4, 1IF5, 1IF6, 1IF7, 1IF8, 1IF9, 1KWQ, 1KWR, 1LG5, 1LG6, 1LGD, 1LUG, 1LZV, 1MOO, 1MUA, 1OKL, 1OKM, 1OKN, 1OQ5, 1RAY, 1RAZ, 1RZA, 1RZB, 1RZC, 1RZD, 1RZE, 1T9N, 1TB0, 1TBT, 1TE3, 1TEQ, 1TEU, 1TG3, 1TG9, 1TH9, 1THK, 1TTM, 1UGA, 1UGB, 1UGC, 1UGD, 1UGE, 1UGF, 1UGG, 1XEG, 1XEV, 1XPZ, 1XQ0, 1YDA, 1YDB, 1YDC, 1YDD, 1YO0, 1YO1, 1YO2, 1Z9Y, 1ZE8, 1ZFK, 1ZFQ, 1ZGE, 1ZGF, 1ZH9, 1ZSA, 1ZSB, 1ZSC, 2ABE, 2AW1, 2AX2, 2CA2, 2CBA, 2CBB, 2CBC, 2CBD, 2CBE, 2EU2, 2EU3, 2EZ7, 2F14, 2FMG, 2FMZ, 2FNK, 2FNM, 2FNN, 2FOQ, 2FOS, 2FOU, 2FOV, 2GD8, 2GEH, 2H15, 2H4N, 2HD6, 2HKK, 2HL4, 2HNC, 2HOC, 2ILI, 2NNG, 2NNO, 2NNS, 2NNV, 2NWO, 2NWP, 2NWY, 2NWZ, 2NXR, 2NXS, 2NXT, 2O4Z, 2OSF, 2OSM, 2POU, 2POV, 2POW, 2Q1B, 2Q1Q, 2Q38, 2QO8, 2QOA, 2QP6, 2VVA, 2VVB, 2WD2, 2WD3, 2WEG, 2WEH, 2WEJ, 2WEO, 2X7S, 2X7T, 2X7U, 3B4F, 3BET, 3BL0, 3BL1, 3C7P, 3CA2, 3CAJ, 3CYU, 3D8W, 3D92, 3D93, 3D9Z, 3DAZ, 3DBU, 3DC3, 3DC9, 3DCC, 3DCS, 3DCW, 3DD0, 3DD8, 3DV7, 3DVB, 3DVC, 3DVD, 3EFI, 3EFT, 3F4X, 3F8E, 3FFP, 3GZ0, 3HFP, 3HKN, 3HKQ, 3HKT, 3HKU, 3HLJ, 3HS4, 3IBI, 3IBL, 3IBN, 3IBU, 3IEO, 3IGP, 3K2F, 3K34, 3K7K, 3KIG, 3KKX, 3KNE, 3KOI, 3KOK, 3KON, 3KS3, 3KWA, 3L14, 3M04, 3M14, 3M1J, 3M1K, 3M1Q, 3M1W, 3M2N, 3M2X, 3M2Y, 3M2Z, 3M3X, 3M40, 3M5E, 3M5S, 3M5T, 3M67, 3M96, 3M98, 3MHC, 3MHI, 3MHL, 3MHM, 3MHO, 3ML2, 3MMF, 3MNA, 3MNH, 3MNI, 3MNJ, 3MNK, 3MNU, 3MWO, 3MYQ, 3MZC, 3N0N, 3N2P, 3N3J, 3N4B, 3NB5, 3NI5, 3NJ9, 3OIK, 3OIL, 3OIM, 3OKU, 3OKV, 3OY0, 3OYQ, 3OYS, 3P3H, 3P3J, 3P44, 3P4V, 3P55, 3P58, 3P5A, 3P5L, 3PJJ, 3PO6, 3PYK, 3QYK, 3R16, 3R17, 3RG3, 3RG4, 3RGE, 3RJ7, 3RLD, 3RYJ, 3RYV, 3RYX, 3RYY, 3RYZ, 3RZ0, 3RZ1, 3RZ5, 3RZ7, 3RZ8, 3S71, 3S72, 3S73, 3S74, 3S75, 3S76, 3S77, 3S78, 3S8X, 3S9T, 3SAP, 3SAX, 3SBH, 3SBI, 3T5U, 3T5Z, 3T82, 3T83, 3T84, 3T85, 3TMJ, 3TVN, 3TVO, 3U3A, 3U45, 3U47, 3U7C, 3V2J, 3V2M, 3V3F, 3V3G, 3V3H, 3V3I, 3V3J, 3V5G, 3V7X, 3VBD, 3ZP9, 4BCW, 4BF1, 4BF6, 4CA2, 4CAC, 4CQ0, 4DZ7, 4DZ9, 4E3D, 4E3F, 4E3G, 4E3H, 4E49, 4E4A, 4E5Q, 4FIK, 4FL7, 4FPT, 4FRC, 4FU5, 4FVN, 4FVO, 4G0C, 4GL1, 4HBA, 4HEW, 4HEY, 4HEZ, 4HF3, 4HT0, 4IDR, 4ILX, 4ITO, 4ITP, 4IWZ, 4JS6, 4JSA, 4JSS, 4JSW, 4JSZ, 4K0S, 4K0T, 4K0Z, 4K13, 4K1Q, 4KAP, 4KNI, 4KNJ, 4KUV, 4KUW, 4KUY, 4KV0, 4L5U, 4L5V, 4L5W, 4LHI, 4LP6, 4M2R, 4M2U, 4M2V, 4M2W, 4MDG, 4MDL, 4MDM, 4MLT, 4MLX, 4MO8, 4MTY, 4N0X, 4N16, 4PQ7, 4PXX, 4PYX, 4PYY, 4PZH, 4Q06, 4Q07, 4Q08, 4Q09, 4Q49, 4Q6D, 4Q6E, 4Q78, 4Q7P, 4Q7S, 4Q7V, 4Q7W, 4Q81, 4Q83, 4Q87, 4Q8X, 4Q8Y, 4Q8Z, 4Q90, 4Q99, 4Q9Y, 4QEF, 4QIY, 4QJM, 4QK1, 4QK2, 4QK3, 4QSA, 4QSB, 4QSI, 4QTL, 4QY3, 4R59, 4R5A, 4R5B, 4RFC, 4RFD, 4RIU, 4RIV, 4RN4, 4RUX, 4RUY, 4RUZ, 4WW6, 4XE1, 4Y0J, 4YGJ, 4YGK, 4YGL, 4YGN, 4Z0Q, 4Z1E, 4Z1J, 4Z1K, 4Z1N, 4ZWI, 4ZWY, 4ZWZ, 5AMD, 5AMG, 5AML, 5BNL, 5BRU, 5BRV, 5BRW, 5BYI, 5CA2, 5CAC, 6CA2, 7CA2, 8CA2, 9CA2, 5E2S, 4YXO, 5CLU, 4YXU, 5EKJ, 5EKH, 1G6V, 5EKM, 4ZX1, 5E2K, 4YYT, 4WL4, 4ZAO, 4ZX0, 4YX4, 4RH2, 4YWP, 4YXI, 5E28, 5E2R, 4ZWX, 5FLT, 5FNH, 5FNJ, 5FLR, 5EH5, 5FLS, 5EHW, 5FNG, 5EH8, 5EHV, 5FNI, 5FNM, 5FNK, 5EH7, 5FLQ, 5FLP, 5FLO
Identifiers
Aliases	CA2, CA-II, CAC, CAII, Car2, HEL-76, HEL-S-282, Carbonic anhydrase II, carbonic anhydrase 2
External IDs	MGI: 88269 HomoloGene: 37256 GeneCards: 760
Gene ontology
Molecular function	• zinc ion binding; • metal ion binding; • protein binding; • lyase activity; • carbonate dehydratase activity; • arylesterase activity;
Cellular component	• cytoplasm; • cytosol; • membrane; • myelin sheath; • apical part of cell; • plasma membrane; • extracellular space; • microvillus; • axon; • basolateral plasma membrane; • extracellular exosome;
Biological process	• one-carbon metabolic process; • regulation of chloride transport; • kidney development; • response to steroid hormone; • angiotensin-activated signaling pathway; • regulation of intracellular pH; • response to zinc ion; • positive regulation of osteoclast differentiation; • positive regulation of bone resorption; • cellular response to fluid shear stress; • positive regulation of synaptic transmission, GABAergic; • response to organic substance; • secretion; • response to estrogen; • morphogenesis of an epithelium; • odontogenesis of dentin-containing tooth; • bicarbonate transport; • positive regulation of cellular pH reduction; • small molecule metabolic process; • response to pH; • regulation of anion transport; • positive regulation of dipeptide transmembrane transport; • carbon dioxide transport;
	Sources:Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
	760
	12349
	ENSG00000104267
	ENSMUSG00000027562
	P00918
	P00920
	NM_001293675; NM_000067
	NM_009801
	NP_000058.1
	NP_033931.4
	Wikidata
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