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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/12/09 12:55:11」(JST)

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Carbocisteine (INN), also called carbocysteine (USAN), is a mucolytic that reduces the viscosity of sputum and so can be used to help relieve the symptoms of chronic obstructive pulmonary disorder (COPD) and bronchiectasis by allowing the sufferer to bring up sputum more easily. Carbocisteine should not be used with antitussives (cough suppressants) or medicines that dry up bronchial secretions.

Carbocisteine is produced by alkylation of cysteine with chloroacetic acid.^[1]

Trade names

Fluifort: Italy
Carbex: Pakistan
Exputex: Ireland
Fluidol, Humotusin: Romania
Rhinathiol: Bulgaria, Congo, Hong Kong, Hungary, Latvia, Lithuania, Malaysia, Oman, Romania, Singapore, South Korea, Switzerland, Taiwan, Thailand, Tunisia, and Vietnam^[2]
Mucodyne: United Kingdom, India, Ireland, Japan, Netherlands, Serbia.
Mucoral: Portugal
Mucosol: Egypt
Solmux, Loviscol: Philippines

References

^ Karlheinz Drauz, Ian Grayson, Axel Kleemann, Hans-Peter Krimmer, Wolfgang Leuchtenberger, Christoph Weckbecker “Amino Acids” in Ullmann's Encyclopedia of Industrial Chemistry, 2007, Wiley-VCH, Weinheim. doi:10.1002/14356007.a02_057.pub2
^ "Rhinathiol". Drugs.com.

UpToDate Contents

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1. COPDに気道粘膜作用薬と気道クリアランスが果たす役割role of mucoactive agents and secretion clearance techniques in copd [show details]
…double-blind trial to receive 500 mg carbocysteine (S-carboxymethyl cysteine) or placebo, three times a day for 12 months . Compared to placebo, patients on carbocysteine had a 0.34 mean reduction in exacerbations …
2. 難治性慢性閉塞性肺疾患（COPD）のマネージメントmanagement of refractory chronic obstructive pulmonary disease [show details]
…to triple inhaler therapy. Thiol derivatives such as N-acetylcysteine (NAC), erdosteine and carbocysteine, are mucolytic agents designed to sever disulfide bonds of mucoproteins and DNA, possibly leading …

English Journal

Carbocisteine protects against emphysema induced by cigarette smoke extract in rats.

Hanaoka M, Droma Y, Chen Y, Agatsuma T, Kitaguchi Y, Voelkel NF, Kubo K.SourceFirst Department of Medicine, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto 390-8621, Japan. masayuki@shinshu-u.ac.jp.
Chest.2011 May;139(5):1101-8. Epub 2010 Sep 16.
PMID 20847042

Comparative metabolism of cyclophosphamide and ifosfamide in the mouse using UPLC-ESI-QTOFMS-based metabolomics.

Li F, Patterson AD, Hofer CC, Krausz KW, Gonzalez FJ, Idle JR.SourceLaboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20852, United States. lif3@mail.nih.gov
Biochemical pharmacology.2010 Oct 1;80(7):1063-74. Epub 2010 Jun 10.
Ifosfamide (IF) and cyclophosphamide (CP) are common chemotherapeutic agents. Interestingly, while the two drugs are isomers, only IF treatment is known to cause nephrotoxicity and neurotoxicity. Therefore, it was anticipated that a comparison of IF and CP drug metabolites in the mouse would reveal
PMID 20541539

Japanese Journal

PEACE研究 (特集 COPD治療の新時代 : 21世紀の「社会的」生活習慣病) -- (知っておくべき日本のCOPD治療のエビデンス)

巽浩一郎,川田奈緒子,寺田二郎 [他]
内科 113(2), 317-320, 2014-02
NAID 40019954981

カルボシステインを主剤とした薬剤による固定薬疹の1例 (特集薬疹・薬物障害)

守屋智枝,藤澤智美,加納宏行 [他]
皮膚科の臨床 55(2), 133-136, 2013-02
NAID 40019591862

A Definite Case of L-carbocisteine-induced Pneumonia with CATCH22 Syndrome

Kudo Kenichiro,Ichihara Eiki,Hisamoto Akiko,Hotta Katsuyuki,Miyahara Nobuaki,Tanimoto Yasushi,Akagi Sadaharu,Kato Katsuya,Tanimoto Mitsune,Kiura Katsuyuki
Internal Medicine 52(1), 97-100, 2013
… A 32-year-old male with CATCH22 syndrome presented with a high fever and productive cough after taking drugs for acute bronchitis, including L-carbocisteine. … Under the assumption of drug-induced pneumonia, or bacterial or viral pneumonia, all drugs including L-carbocisteine were discontinued, and antibiotics were started. … A drug-induced lymphocyte stimulation test was positive only for L-carbocisteine. …
NAID 130003365553

「カルボシステイン」

Carbocisteine
Names
	IUPAC name (R)-2-Amino-3-(carboxymethylsulfanyl)propanoic acid
	Other names S-Carboxymethyl-L-cysteine; Mucodyne, Solmux, Rhinathiol, Humex, Lisomucil, Fluditec, Exputex, Mucolit, Reodyn, Carbotoux, Flemex, Carbolin, Muflex
Identifiers
CAS Number	638-23-3 (R) ; 2387-59-9 (RS)
ChEBI	CHEBI:16163
ChEMBL	ChEMBL396416
ChemSpider	168055
DrugBank	DB04339
	InChI InChI=1S/C5H9NO4S/c6-3(5(9)10)1-11-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1 Key: GBFLZEXEOZUWRN-VKHMYHEASA-N ; InChI=1/C5H9NO4S/c6-3(5(9)10)1-11-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10) Key: GBFLZEXEOZUWRN-UHFFFAOYAN ; InChI=1/C5H9NO4S/c6-3(5(9)10)1-11-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1 Key: GBFLZEXEOZUWRN-VKHMYHEABX ;
Jmol interactive 3D	Image; Image
KEGG	D06393
PubChem	193653
	SMILES O=C(O)C(N)CSCC(=O)O ; O=C(O)[C@@H](N)CSCC(=O)O ;
UNII	740J2QX53R
Properties
Chemical formula	C5H9NO4S
Molar mass	179.19 g·mol−1
Appearance	Colorless solid
Melting point	204 to 207 °C (399 to 405 °F; 477 to 480 K)
Pharmacology
ATC code	R05CB03
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
	verify (what is ?)
	Infobox references

　　[★]

英: carbocysteine、carbocisteine
同: L-カルボシステイン、L-carbocisteine、S-カルボキシメチルシステイン S-carboxymethyl cysteine
商: C-チステン、カージリン、カルブタン、クインスロン、サワテン、シスカルボン、シスダイン、ムコダイン、ムコチオ、ムコトロン、メチスタ、ルボラボン
関: 去たん剤

概念

去痰薬;気道粘液溶解
システインの残基のH-がHOOC-CH2-で置換されたアミノ酸

作用

喀痰中のフコムチンを減少させ、シアロムチンを増加させる
粘液構成成分の調整作用、喀痰粘度低下作用、喀痰流動性の改善作用、線毛細胞修復作用を有する

参考

wikipedia en

http://en.wikipedia.org/wiki/Carbocisteine

[1] Karlheinz Drauz, Ian Grayson, Axel Kleemann, Hans-Peter Krimmer, Wolfgang Leuchtenberger, Christoph Weckbecker “Amino Acids” in Ullmann's Encyclopedia of Industrial Chemistry, 2007, Wiley-VCH, Weinheim. doi:10.1002/14356007.a02_057.pub2

[2] "Rhinathiol". Drugs.com.

匿名

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案内

案内

carbocisteine