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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/10/22 09:44:32」(JST)

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Capreomycin is a peptide antibiotic, commonly grouped with the aminoglycosides, which is given in combination with other antibiotics for MDR-tuberculosis. Adverse effects include nephrotoxicity and 8th cranial auditory vestibular nerve nerve toxicity.

The drug should not be given with streptomycin or other drugs that may damage the auditory vestibular nerve. Patients on this drug will often require audiology tests.

It is a cyclic peptide. Capreomycin is administered intramuscularly and shows bacteriostatic activity. ^[1]

References[edit]

^ "Capreomycin binds across the ribosomal subunit interface using tlyA-encoded 2'-O-methylations in 16S and 23S rRNAs". Mol. Cell 23 (2): 173–82. July 2006. doi:10.1016/j.molcel.2006.05.044. PMID 16857584.

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1. セカンドラインの抗結核療法 second line antituberculous therapy
2. 広範囲薬剤耐性結核の臨床症状、診断、および治療 clinical manifestations diagnosis and treatment of extensively drug resistant tuberculosis
3. 薬剤耐性結核の診断、治療、および予防 diagnosis treatment and prevention of drug resistant tuberculosis
4. 妊娠中の結核 tuberculosis in pregnancy
5. 非HIV感染患者における肺結核の治療 treatment of pulmonary tuberculosis in hiv uninfected patients

English Journal

Powder, capsule and device: An imperative ménage à trois for respirable dry powders.

Schoubben A1, Blasi P2, Giontella A3, Giovagnoli S4, Ricci M5.
International journal of pharmaceutics.Int J Pharm.2015 Oct 15;494(1):40-8. doi: 10.1016/j.ijpharm.2015.08.012. Epub 2015 Aug 5.
OBJECTIVES: The development of inhaled products to treat or to prevent lung infection is a very active research field in drug delivery. The pulmonary route is extremely attractive but very challenging. This paper reports the study of excipient, capsule brand and device influence on the aerodynamic b
PMID 26255220

First series of patients with XDR and pre-XDR TB treated with regimens that included meropenen-clavulanate in Argentina.

Palmero D1, González Montaner P2, Cufré M2, García A2, Vescovo M2, Poggi S2.
Archivos de bronconeumologia.Arch Bronconeumol.2015 Oct;51(10):e49-e52. doi: 10.1016/j.arbres.2015.03.012. Epub 2015 May 27.
XDR (extensively drug-resistant) and pre-XDR tuberculosis (TB) seriously compromise prognosis and treatment possibilities, and inevitably require the use of group V drugs (World Health Organization). The progress of all patients with XDR and pre-XDR TB seen in a specialized unit during 2012 and 2013
PMID 26026689

Primary Capreomycin Resistance Is Common and Associated With Early Mortality in Patients With Extensively Drug-Resistant Tuberculosis in KwaZulu-Natal, South Africa.

OʼDonnell MR1, Pillay M, Pillay M, Werner L, Master I, Wolf A, Mathema B, Coovadia YM, Mlisana K, Horsburgh CR, Padayatchi N.
Journal of acquired immune deficiency syndromes (1999).J Acquir Immune Defic Syndr.2015 Aug 15;69(5):536-43. doi: 10.1097/QAI.0000000000000650.
BACKGROUND: Capreomycin is a key antimycobacterial drug in treatment of extensively drug-resistant tuberculosis (XDR-TB). Drug-susceptibility testing (DST) for capreomycin is not routinely performed in newly diagnosed XDR-TB in South Africa. We performed this study to assess the prevalence, clinical
PMID 25886924

Japanese Journal

Mycobacterium szulgai 肺感染症の1例

池上達義,渡邊茂樹,杉田孝和,堀川禎夫,鈴木雄二郎,西山秀樹,前川暢夫
結核 77(5), 427-431, 2002-05-15
… Antimicrobial susceptibility testing indicated that the isolate was sensitive to most common antimycobacterial drugs except capreomycin (CPM) and p-aminosalicylic acid (PAS), and was also sensitive to clarithromycin and fluoroquinolones including ofloxacin, levofloxacin, sparfloxacin, and ciprofloxacin. …
NAID 10008879622

Biosynthesis of capreomycin. 2. Incorporation of L-serine, L-alanine, and L-2,3-diaminopropionic acid

WANG M.
Journal of Organic Chemistry 58, 5176-5180, 1993
NAID 80007272549

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★リンクテーブル★

リンク元	「カプレオマイシン」「CPRM」
拡張検索	「capreomycin sulfate」

「カプレオマイシン」

Capreomycin
Systematic (IUPAC) name
	(3S)-3,6-diamino-N-[[(2S,5S,8E,11S,15S)-15-amino-11-[(4R)-2-amino-3,4,5,6-tetrahydropyrimidin-4-yl]-8-[(carbamoylamino)methylidene]-2-(hydroxymethyl)-3,6,9,12,16-pentaoxo-1,4,7,10,13-pentazacyclohexadec-5-yl]methyl]hexanamide; (3S)-3,6-diamino-N-[[(2S,5S,8E,11S,15S)-15-amino-11-[(4R)-2-amino-3,4,5,6-tetrahydropyrimidin-4-yl]-8-[(carbamoylamino)methylidene]-2-methyl-3,6,9,12,16-pentaoxo-1,4,7,10,13-pentazacyclohexadec-5-yl]methyl]hexanamide
Clinical data
AHFS/Drugs.com	monograph
MedlinePlus	a682860
Pregnancy cat.	?
Legal status	?
Identifiers
CAS number	11003-38-6
ATC code	J04AB30
PubChem	CID 3032400
DrugBank	DB00314
ChemSpider	21106276
UNII	232HYX66HC
KEGG	D00135
ChEMBL	CHEMBL1201252
NIAID ChemDB	007653
Chemical data
Formula	C25H44N14O8
Mol. mass	668.706 g/mol
	InChI InChI=1S/C25H44N14O8.C25H44N14O7/c26-4-1-2-11(27)6-17(41)32-8-14-20(43)35-15(9-34-25(30)47)21(44)39-18(13-3-5-31-24(29)38-13)23(46)33-7-12(28)19(42)37-16(10-40)22(45)36-14;1-11-19(41)36-15(9-32-17(40)7-12(27)3-2-5-26)21(43)37-16(10-34-25(30)46)22(44)39-18(14-4-6-31-24(29)38-14)23(45)33-8-13(28)20(42)35-11/h9,11-14,16,18,40H,1-8,10,26-28H2,(H,32,41)(H,33,46)(H,35,43)(H,36,45)(H,37,42)(H,39,44)(H3,29,31,38)(H3,30,34,47);10-15,18H,2-9,26-28H2,1H3,(H,32,40)(H,33,45)(H,35,42)(H,36,41)(H,37,43)(H,39,44)(H3,29,31,38)(H3,30,34,46)/b15-9-;16-10-/t11-,12?,13?,14+,16+,18?;11-,12+,13?,14?,15-,18?/m10/s1 ; Key:VCOPTHOUUNAYKQ-TWKMCICTSA-N ;
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