English Journal

Pathogenesis of solute-free water retention in experimental ascitic cirrhosis: is vasopressin the only culprit?

Sansoè G1, Aragno M2, Mastrocola R2, Parola M2.
Clinical science (London, England : 1979).Clin Sci (Lond).2016 Jan 1;130(2):117-24. doi: 10.1042/CS20150479. Epub 2015 Oct 30.
Catecholamines trigger proximal tubular fluid retention and reduce renal excretion of solute-free water. In advanced cirrhosis, non-osmotic hypersecretion of vasopressin (antidiuretic hormone or ADH) is considered the cause of dilutional hyponatraemia, but ADH V2 receptor antagonists are not benefic
PMID 26519424

Topical Mineralocorticoid Receptor Blockade Limits Glucocorticoid-Induced Epidermal Atrophy in Human Skin.

Maubec E1, Laouénan C2, Deschamps L3, Nguyen VT4, Scheer-Senyarich I5, Wackenheim-Jacobs AC6, Steff M1, Duhamel S7, Tubiana S8, Brahimi N5, Leclerc-Mercier S9, Crickx B1, Perret C7, Aractingi S10, Escoubet B11, Duval X8, Arnaud P12, Jaisser F7, Mentré F2, Farman N7.
The Journal of investigative dermatology.J Invest Dermatol.2015 Jul;135(7):1781-9. doi: 10.1038/jid.2015.44. Epub 2015 Feb 10.
A major deleterious side effect of glucocorticoids is skin atrophy. Glucocorticoids activate the glucocorticoid and the mineralocorticoid (MR) receptor, both present in the epidermis. We hypothesized that glucocorticoid-induced epidermal atrophy may be related to inappropriate occupancy of MR by glu
PMID 25668238

Dose-dependency of clonidine's effects in ascitic cirrhotic rats: comparison with α1-adrenergic agonist midodrine.

Sansoè G1, Aragno M2, Mastrocola R2, Parola M2.
Liver international : official journal of the International Association for the Study of the Liver.Liver Int.2015 Jun 30. doi: 10.1111/liv.12905. [Epub ahead of print]
BACKGROUND & AIMS: Sympathetic nervous system (SNS) activation decreases response to diuretics, but both α1-adrenoceptor agonists and sympatholytic α2-adrenoceptor agonists are recommended in the management of ascitic cirrhosis. We intend to compare the effects of increasing doses of clonidine
PMID 26121993

Japanese Journal

Electropharmacological Effects of a Spironolactone Derivative, Potassium Canrenoate, Assessed in the Halothane-Anesthetized Canine Model

Sugiyama Atsushi,Satoh Yoshioki,Takahara Akira [他],ANDO Kentaro,WANG Kai,HONSHO Sachiko,NAKAMURA Yuji,HASHIMOTO Keitaro
Journal of pharmacological sciences 96(4), 436-443, 2004-12-01
… In this study, we examined in vivo electropharmacological effects of an active derivative of spironolactone, potassium canrenoate, using a halothane-anesthetized canine model. … Potassium canrenoate was intravenously administered in three doses of 1, 10, and 100 mg/kg per 10 min with a pause of 20 min between doses (n = 5). …
NAID 10014075829

OE-275 A Spironolactone Derivative, Potassium Canrenoate, Prolongs the QT Interval but Shortens the Electrically Vulnerable Period of In Vivo Canine Hearts(Cardiovascular Pharmacology, Basic/Clinical 1 (H) : OE34)(Oral Presentation (English))

Sugiyama Atsushi,Takahara Akira,Satoh Yoshioki,Hashimoto Keitaro
Circulation journal : official journal of the Japanese Circulation Society 68(Supplement_I), 207, 2004-03-01
NAID 110002700507

小澤和雄,阿部誠治,根本亜紀子,伊藤葉子,佐藤和恵,山元俊憲,村山純一郎
医療薬学 28(4), 331-338, 2002-08-10
… We examined the compatibility of a commercialized potassium canrenoate preparation (Soldactone^[○!R]) with 124 other kinds of currently prescribed injectable preparations as counter substances based upon the physico chemical parameters : actually, the appearance, pH, and the concentration of canrenoate were used as markers after mixing for 24 hours with other injectable preparations, since appearances can be deceptive. …
NAID 110001166615