cannabinoid receptor antagonist

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2014/10/15 08:04:55」(JST)

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  • Ultralow doses of cannabinoid drugs protect the mouse brain from inflammation-induced cognitive damage.
  • Fishbein-Kaminietsky M1, Gafni M, Sarne Y.
  • Journal of neuroscience research.J Neurosci Res.2014 Dec;92(12):1669-77. doi: 10.1002/jnr.23452. Epub 2014 Jul 16.
  • In our previous studies, we found that a single ultralow dose of tetrahydrocannabinol (THC; 0.002 mg/kg, three to four orders of magnitude lower than the conventional doses) protects the brain from different insults that cause cognitive deficits. Because various insults may trigger a neuroinflammato
  • PMID 25042014
  • Anti-aversive role of the endocannabinoid system in the periaqueductal gray stimulation model of panic attacks in rats.
  • Viana TG1, Hott SC, Resstel LB, Aguiar DC, Moreira FA.
  • Psychopharmacology.Psychopharmacology (Berl).2014 Nov 13. [Epub ahead of print]
  • RATIONALE: Direct activation of the cannabinoid CB1 receptor in the dorsolateral periaqueductal gray (dlPAG) inhibits anxiety- and panic-related behaviours in experimental animals. It has remained unclear, however, whether the local endocannabinoid signalling is recruited as a protective mechanism a
  • PMID 25388290


  • Stimulatory and Inhibitory Roles of Brain 2-Arachidonoylglycerol in Bombesin-Induced Central Activation of Adrenomedullary Outflow in Rats
  • Shimizu Takahiro,Tanaka Kenjiro,Yokotani Kunihiko
  • Journal of pharmacological sciences 121(2), 157-171, 2013-02-20
  • … 2-Arachidonoylglycerol (2-AG) is recognized as a potent endocannabinoid, which reduces synaptic transmission through cannabinoid CB1 receptors, and is hydrolyzed by monoacylglycerol lipase (MGL) to arachidonic acid (AA), a cyclooxygenase substrate. …
  • NAID 10031156945
  • ヒト悪性神経膠腫細胞U87MGにおけるペプチドグリカン誘発性のNF-κBリン酸化と細胞成長のカンナビノイドによる抑制
  • Echigo Ryosuke,Sugimoto Naotoshi,Yachie Akihiro,Ohno-Shosaku Takako
  • Oncology Reports 28(4), 1176-1170, 2012-10
  • … Peptidoglycan (PGN), a main cell wall component of Gram-positive bacteria, stimulates Toll-like receptor 2 (TLR-2) and activates a number of inflammatory pathways, including NF-κB. … The purpose of this study was to investigate whether cannabinoids can suppress the PGN-induced activation of NF-κB and cell growth via cannabinoid receptors in U87MG human malignant glioma cells. …
  • NAID 120005285923


The discovery of the endogenous cannabinoid system led to the development of CB1 receptor antagonists. The first cannabinoid receptor antagonist, rimonabant,... ... CB 1 receptors are coupled through G i/o proteins and inhibit adenylyl cyclase and activate ...
Otenabant (CP-945598) HCl is a potent and selective cannabinoid receptor CB1 antagonist with Ki of 0.7 nM, exhibits 10,000-fold greater selectivity against human CB2 receptor. Phase 1. S2778 GW842166X is a potent and EC50 ...



関連記事antagonist」「receptor」「cannabinoid receptor


  [★] 拮抗薬

WordNet   license wordnet

「a drug that neutralizes or counteracts the effects of another drug」

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「a muscle that relaxes while another contracts; "when bending the elbow the triceps are the antagonist"」

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  [★] 受容体

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「a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response」

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「=sense organ / 受信装置」

cannabinoid receptor」


cannabinoid receptors