cannabinoid receptor agonist

出典: meddic

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2014/06/03 11:28:26」(JST)

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  • Dysregulation of cannabinoid CB1 receptor and associated signaling networks in brains of cocaine addicts and cocaine-treated rodents.
  • Alvaro-Bartolomé M, García-Sevilla JA.SourceLaboratori de Neurofarmacologia, Institut Universitari d'Investigació en Ciències de la Salut (IUNICS), Universitat de les Illes Balears (UIB) and Redes Temáticas de Investigación Cooperativa en Salud (RETICS-RTA), Cra. Valldemossa km 7.5, E-07122 Palma de Mallorca, Spain.
  • Neuroscience.Neuroscience.2013 Sep 5;247:294-308. doi: 10.1016/j.neuroscience.2013.05.035. Epub 2013 May 29.
  • The endocannabinoid system is implicated in the neurobiology of cocaine addiction. This study evaluated the status of cannabinoid (CB) CB1 and CB2 receptors, the endocytic cycle of CB1 receptors, G protein-coupled receptor regulatory kinases (GRK), and associated signaling (mammalian target of rapam
  • PMID 23727505
  • The non-selective cannabinoid receptor agonist WIN 55,212-2 attenuates responses of C-fiber nociceptors in a murine model of cancer pain.
  • Uhelski ML, Cain DM, Harding-Rose C, Simone DA.SourceDepartment of Diagnostic and Biological Sciences, University of Minnesota, Minneapolis, MN 55447, United States.
  • Neuroscience.Neuroscience.2013 Sep 5;247:84-94. doi: 10.1016/j.neuroscience.2013.05.003. Epub 2013 May 11.
  • Pain from cancer can be severe, difficult to treat, and greatly diminishes patients' quality of life. It is therefore important to gain new information on the mechanisms of cancer pain and develop new treatment strategies. We have used a murine model of bone cancer pain to investigate underlying per
  • PMID 23673278


  • Endocannabinoid-mediated retrograde modulation of synaptic transmission
  • Ohno-Shosaku Takako,Kano Masanobu
  • Current Opinion in Neurobiology 29, 1-8, 2014-12
  • … Upon postsynaptic activation, 2-AG is released immediately after de novo synthesis, activates presynaptic CB1 cannabinoid receptors, and transiently suppresses neurotransmitter release. … When CB1 receptor activation is combined with some other factors such as presynaptic activity, the suppression is converted to a long-lasting form. …
  • NAID 120005435504
  • Control of synaptic function by endocannabinoid-mediated retrograde signaling
  • KANO Masanobu
  • Proceedings of the Japan Academy, Series B 90(7), 235-250, 2014
  • … The released 2-AG then acts retrogradely onto presynaptic cannabinoid CB1 receptors and induces suppression of neurotransmitter release either transiently or persistently. …
  • NAID 130004678273


The discovery of the endogenous cannabinoid system led to the development of CB1 receptor antagonists. The first cannabinoid receptor "antagonist," rimonabant, was described in 1994. Rimonabant blocks the CB1 receptor selectively and it ...
Certain tumors, especially gliomas, express CB2 receptors. Guzman and coworkers have shown that Δ9-tetrahydrocannabinol and WIN-55,212-2, two non -selective cannabinoid agonists, induce the regression or eradication of malignant ...



関連記事agonist」「receptor」「receptor agonist」「cannabinoid receptor


  [★] 作動薬

WordNet   license wordnet

「(biochemistry) a drug that can combine with a receptor on a cell to produce a physiological reaction」

WordNet   license wordnet

「a muscle that contracts while another relaxes; "when bending the elbow the biceps are the agonist"」

WordNet   license wordnet

「someone involved in a contest or battle (as in an agon)」


  [★] 受容体

WordNet   license wordnet

「a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response」

PrepTutorEJDIC   license prepejdic

「=sense organ / 受信装置」

receptor agonist」



cannabinoid receptor」


cannabinoid receptors