WordNet

executed with proper legal authority; "a binding contract"
the protective covering on the front, back, and spine of a book; "the book had a leather binding" (同)book binding, cover, back
strip sewn over or along an edge for reinforcement or decoration
the capacity to attract and hold something
territory over which rule or control is exercised; "his domain extended into Europe"; "he made it the law of the land" (同)demesne, land
(mathematics) the set of values of the independent variable for which a function is defined (同)domain of a function

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/08/26 05:59:02」(JST)

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Multiple domains in the C-terminus of NMDA receptor GluN2B subunit contribute to neuronal death following in vitro ischemia.

Vieira MM1, Schmidt J2, Ferreira JS1, She K3, Oku S3, Mele M1, Santos AE4, Duarte CB5, Craig AM3, Carvalho AL6.
Neurobiology of disease.Neurobiol Dis.2016 May;89:223-34. doi: 10.1016/j.nbd.2015.11.007. Epub 2015 Nov 12.
Global cerebral ischemia induces selective degeneration of specific subsets of neurons throughout the brain, particularly in the hippocampus and cortex. One of the major hallmarks of cerebral ischemia is excitotoxicity, characterized by overactivation of glutamate receptors leading to intracellular
PMID 26581639

Fcγ1 fragment of IgG1 as a powerful affinity tag in recombinant Fc-fusion proteins: immunological, biochemical and therapeutic properties.

Soleimanpour S1, Hassannia T2, Motiee M3, Amini AA4, Rezaee SA3.
Critical reviews in biotechnology.Crit Rev Biotechnol.2016 Apr 6:1-22. [Epub ahead of print]
Affinity tags are vital tools for the production of high-throughput recombinant proteins. Several affinity tags, such as the hexahistidine tag, maltose-binding protein, streptavidin-binding peptide tag, calmodulin-binding peptide, c-Myc tag, glutathione S-transferase and FLAG tag, have been introduc
PMID 27049690

Shukla D1,2,3, Peck A4, Pande VS1,2.
Nature communications.Nat Commun.2016 Apr 4;7:10910. doi: 10.1038/ncomms10910.
Calmodulin (CaM) is a ubiquitous Ca(2+) sensor and a crucial signalling hub in many pathways aberrantly activated in disease. However, the mechanistic basis of its ability to bind diverse signalling molecules including G-protein-coupled receptors, ion channels and kinases remains poorly understood.
PMID 27040077

Strong Interaction of Bovine Brain Calmodulin with Bisphenol A : Effects on Secondary Structure, Conformation, Ca²⁺-Binding Affinity, Gibbs Energy, and Domain Cooperativity

Murayama Koichi,Sonoyama Masashi,Matsuda Sadayuki
Bulletin of the Chemical Society of Japan 88(6), 880-887, 2015
… Calmodulin (CaM) is a major member of the family of Ca2+-binding proteins. … In this study, effects on Ca2+-binding affinity and conformation of CaM by bisphenol A (BPA) were investigated by using circular dichroism and UV absorbance spectroscopy, domain-specific fluorescence spectroscopy, and isothermal titration calorimetry. …
NAID 130005075687

Negatively Charged Amino Acids Near and in Transient Receptor Potential (TRP) Domain of TRPM4 Channel Are One Determinant of Its Ca2+ Sensitivity.

Yamaguchi Soichiro,Tanimoto Akira,Otsuguro Ken-ichi,Hibino Hiroshi,Ito Shigeo
The Journal of biological chemistry 289(51), 35265-35282, 2014-12-19
… The Ca2+ sensitivity is known to be regulated by calmodulin and membrane phosphoinositides, such as phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2). … Although these regulators must play important roles in controlling TRPM4 activity, mutation analyses of the calmodulin-binding sites have suggested that Ca2+ binds to TRPM4 directly. … However, the intrinsic binding sites in TRPM4 remain to be elucidated. …
NAID 120005522343

Ran and Calcineurin Can Participate Collaboratively in the Regulation of Spermatogenesis in Scallop

Hino Hirotsugu,Arimoto Kana,Yazawa Michio,Murakami Yota,Nakatomi Akiko
Marine Biotechnology 14(4), 479-490, 2012-08
… Calcineurin is a calcium/calmodulin-dependent protein phosphatase that plays important roles in the transduction of calcium signals in a variety of tissues. … A novel calcineurin-binding protein, CaNBP75, has been identified in scallop testis. … The C-terminal region of CaNBP75 is homologous to the C-terminal region of RanBP3, a Ran binding domain-containing protein. …
NAID 120004593470

Available protein structures:
Pfam	structures
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

CaMBD
	solution structure of the calmodulin binding domain (cambd) of small conductanceCa2+-activated potassium channels (sk2)
Identifiers
Symbol	CaMBD
Pfam	PF02888
InterPro	IPR004178
SCOP	1kkd
SUPERFAMILY	1kkd
Available protein structures:
Pfam	structures
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary