WordNet
- a radioactive transuranic element; discovered by bombarding curium with alpha particles (同)Cf, atomic number 98
- a gyromitra with a brown puffed up fertile part and a thick fluted stalk; found under conifers in California (同)California false morel
- North American sabertooth; culmination of sabertooth development
PrepTutorEJDIC
- =caliph
- カリフォルニウム(人工放射性金属元素;化学記号は『Cf』)
- =caliphate
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/01/15 17:24:15」(JST)
[Wiki en表示]
Calif may refer to:
- Caliph
- Abbreviation of California
- Calif, A subsidiary company of French bank Société Générale
English Journal
- Brain Pyroglutamate Amyloid-Beta is Produced by Cathepsin B and is Reduced by the Cysteine Protease Inhibitor E64d, Representing a Potential Alzheimer's Disease Therapeutic.
- Hook G1, Yu J2, Toneff T3, Kindy M2, Hook V3.Author information 1American Life Science Pharmaceuticals, La Jolla, CA, USA.2Department of Neurosciences, Medical University of South Carolina, Charleston, SC, USA Ralph H. Johnson VA Medical Center, Charleston, SC, USA.3Skaggs School of Pharmacy and Pharmaceutical Sciences, Department of Neurosciences and Pharmacology, Univ. of Calif., San Diego, La Jolla, CA, USA.AbstractPyroglutamate amyloid-β peptides (pGlu-Aβ) are particularly pernicious forms of amyloid-β peptides (Aβ) present in Alzheimer's disease (AD) brains. pGlu-Aβ peptides are N-terminally truncated forms of full-length Aβ peptides (flAβ(1-40/42)) in which the N-terminal glutamate is cyclized to pyroglutamate to generate pGlu-Aβ(3-40/42). β-secretase cleavage of amyloid-β precursor protein (AβPP) produces flAβ(1-40/42), but it is not yet known whether the β-secretase BACE1 or the alternative β-secretase cathepsin B (CatB) participate in the production of pGlu-Aβ. Therefore, this study examined the effects of gene knockout of these proteases on brain pGlu-Aβ levels in transgenic AβPPLon mice, which express AβPP isoform 695 and have the wild-type (wt) β-secretase activity found in most AD patients. Knockout or overexpression of the CatB gene reduced or increased, respectively, pGlu-Aβ(3-40/42), flAβ(1-40/42), and pGlu-Aβ plaque load, but knockout of the BACE1 gene had no effect on those parameters in the transgenic mice. Treatment of AβPPLon mice with E64d, a cysteine protease inhibitor of CatB, also reduced brain pGlu-Aβ(3-42), flAβ(1-40/42), and pGlu-Aβ plaque load. Treatment of neuronal-like chromaffin cells with CA074Me, an inhibitor of CatB, resulted in reduced levels of pGlu-Aβ(3-40) released from the activity-dependent, regulated secretory pathway. Moreover, CatB knockout and E64d treatment has been previously shown to improve memory deficits in the AβPPLon mice. These data illustrate the role of CatB in producing pGlu-Aβ and flAβ that participate as key factors in the development of AD. The advantages of CatB inhibitors, especially E64d and its derivatives, as alternatives to BACE1 inhibitors in treating AD patients are discussed.
- Journal of Alzheimer's disease : JAD.J Alzheimers Dis.2014 Mar 4. [Epub ahead of print]
- Pyroglutamate amyloid-β peptides (pGlu-Aβ) are particularly pernicious forms of amyloid-β peptides (Aβ) present in Alzheimer's disease (AD) brains. pGlu-Aβ peptides are N-terminally truncated forms of full-length Aβ peptides (flAβ(1-40/42)) in which the N-terminal glutamate is cyclized to pyr
- PMID 24595198
- NSF workshop report: Discovering general principles of nervous system organization by comparing brain maps across species.
- Striedter GF1, Belgard TG, Chen CC, Davis FP, Finlay BL, Güntürkün O, Hale ME, Harris JA, Hecht EE, Hof PR, Hofmann HA, Holland LZ, Iwaniuk AN, Jarvis ED, Karten HJ, Katz PS, Kristan WB, Macagno ER, Mitra PP, Moroz LL, Preuss TM, Ragsdale CW, Sherwood CC, Stevens CF, Stüttgen MC, Tsumoto T, Wilczynski W.Author information 1Department of Neurobiology and Behavior, University of California Irvine, Irvine, Calif.AbstractEfforts to understand nervous system structure and function have received new impetus from the federal Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative. Comparative analyses can contribute to this effort by leading to the discovery of general principles of neural circuit design, information processing, and gene-structure-function relationships that are not apparent from studies on single species. We here propose to extend the comparative approach to nervous system 'maps' comprising molecular, anatomical, and physiological data. This research will identify which neural features are likely to generalize across species, and which are unlikely to be broadly conserved. It will also suggest causal relationships between genes, development, adult anatomy, physiology, and, ultimately, behavior. These causal hypotheses can then be tested experimentally. Finally, insights from comparative research can inspire and guide technological development. To promote this research agenda, we recommend that teams of investigators coalesce around specific research questions and select a set of 'reference species' to anchor their comparative analyses. These reference species should be chosen not just for practical advantages, but also with regard for their phylogenetic position, behavioral repertoire, well-annotated genome, or other strategic reasons. We envision that the nervous systems of these reference species will be mapped in more detail than those of other species. The collected data may range from the molecular to the behavioral, depending on the research question. To integrate across levels of analysis and across species, standards for data collection, annotation, archiving, and distribution must be developed and respected. To that end, it will help to form networks or consortia of researchers and centers for science, technology, and education that focus on organized data collection, distribution, and training. These activities could be supported, at least in part, through existing mechanisms at NSF, NIH, and other agencies. It will also be important to develop new integrated software and database systems for cross-species data analyses. Multidisciplinary efforts to develop such analytical tools should be supported financially. Finally, training opportunities should be created to stimulate multidisciplinary, integrative research into brain structure, function, and evolution. J. Comp. Neurol., 2014. © 2014 Wiley Periodicals, Inc.
- The Journal of comparative neurology.J Comp Neurol.2014 Mar 4. doi: 10.1002/cne.23568. [Epub ahead of print]
- Efforts to understand nervous system structure and function have received new impetus from the federal Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative. Comparative analyses can contribute to this effort by leading to the discovery of general principles of neural circ
- PMID 24596113
- Burnout in pediatric residents over a 2-year period: a longitudinal study.
- Pantaleoni JL1, Augustine EM2, Sourkes BM3, Bachrach LK3.Author information 1Department of Pediatrics, Stanford University School of Medicine, Palo Alto, Calif. Electronic address: julie.pantaleoni@stanford.edu.2Children's National Medical Center, Washington, DC.3Department of Pediatrics, Stanford University School of Medicine, Palo Alto, Calif.AbstractOBJECTIVE: Burnout is a work-related syndrome characterized by emotional exhaustion (EE), depersonalization (DP), and lack of personal accomplishment (PA). We hypothesized that the transition into an environment of high physical, intellectual, and emotional demands of the medical profession would lead to an increase in the prevalence of burnout in pediatric residents, which would remain high throughout residency.
- Academic pediatrics.Acad Pediatr.2014 Mar-Apr;14(2):167-72. doi: 10.1016/j.acap.2013.12.001.
- OBJECTIVE: Burnout is a work-related syndrome characterized by emotional exhaustion (EE), depersonalization (DP), and lack of personal accomplishment (PA). We hypothesized that the transition into an environment of high physical, intellectual, and emotional demands of the medical profession would le
- PMID 24602580
Japanese Journal
- Fabian Drixler, Mabiki: Infanticide and Population Growth in Eastern Japan, 1660-1950 (Asia: Local Studies/Global Themes), Oakland, Calif., University of California Press, 2013, 439p
- 司法の自己抑制の興亡 Richard A. Posner, The Rise and Fall of Judicial Self-Restraint, 100 CALIF. L. REV. 519-556 (2012)
- フラクショナルレーザー療法の実際;その基礎と応用について-
- 須賀 康
- 日本レーザー医学会誌 31(1), 65-71, 2009
- フラクショナルレーザー療法は,きわめて微細なレーザー光(micro laser beam)を一定の密度で皮膚に照射してゆく治療法である.このようなレーザー照射法では,周囲の皮膚が熱緩和(thermal relaxation)の役割を果たし,表皮や真皮に対してのburn-like thermal damageを最小限に抑えることができる.一方では,micro laser beamの熱刺激により表皮の …
- NAID 130004893492
Related Pictures
★リンクテーブル★
[★]
カリホルニウム
- 関
- Cf
[★]
マートル
- 関
- Umbellularia
[★]
ジャンボアメフラシ
[★]
カロリー
- 関
- Cal、calorie、calory