関: calmodulin-binding protein

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/11/07 04:41:56」(JST)

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Caldesmon is a protein that in humans is encoded by the CALD1 gene.^[1]^[2]

Caldesmon is a calmodulin binding protein. Like calponin, caldesmon tonically inhibits the ATPase activity of myosin in smooth muscle.

This gene encodes a calmodulin- and actin-binding protein that plays an essential role in the regulation of smooth muscle and nonmuscle contraction. The conserved domain of this protein possesses the binding activities to Ca⁺⁺-calmodulin, actin, tropomyosin, myosin, and phospholipids. This protein is a potent inhibitor of the actin-tropomyosin activated myosin MgATPase, and serves as a mediating factor for Ca⁺⁺-dependent inhibition of smooth muscle contraction. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms.^[2]

Immunochemistry

In diagnostic immunochemistry, caldesmon is a marker for smooth muscle differentiation.

References

^ Novy RE, Lin JL, Lin JJ (Oct 1991). "Characterization of cDNA clones encoding a human fibroblast caldesmon isoform and analysis of caldesmon expression in normal and transformed cells". J Biol Chem 266 (25): 16917–24. PMID 1885618.
^ ^a ^b "Entrez Gene: CALD1 caldesmon 1".

External links

Caldesmon at the US National Library of Medicine Medical Subject Headings (MeSH)

This article on a gene on human chromosome 7 is a stub. You can help Wikipedia by expanding it.

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1. 子宮平滑筋腫（子宮筋腫）の変異型 variants of uterine leiomyomas fibroids
2. 子宮内膜間質腫瘍の分類および治療 classification and treatment of endometrial stromal tumors

English Journal

Potentially neuroprotective gene modulation in an in vitro model of mild traumatic brain injury.

Di Pietro V, Amorini AM, Tavazzi B, Hovda DA, Signoretti S, Giza CC, Lazzarino G, Vagnozzi R, Lazzarino G, Belli A.SourceNeuropharmacology and Neurobiology Section, School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.
Molecular and cellular biochemistry.Mol Cell Biochem.2013 Mar;375(1-2):185-98. doi: 10.1007/s11010-012-1541-2. Epub 2012 Dec 15.
In this study, we investigated the hypothesis that mild traumatic brain injury (mTBI) triggers a controlled gene program as an adaptive response finalized to neuroprotection, similar to that found in hibernators and in ischemic preconditioning. A stretch injury device was used to produce an equi-bia
PMID 23242602

Epstein-Barr virus-associated smooth muscle tumor-report of 3 tumors including 1 intracerebral case with a prominent intratumoral B-lymphocytic component and plasma cells.

Petersson F.SourceDepartment of Pathology, National University Health System, Singapore. fredrikpetersson@live.se
Annals of diagnostic pathology.Ann Diagn Pathol.2013 Feb;17(1):91-8. doi: 10.1016/j.anndiagpath.2012.07.007. Epub 2012 Sep 27.
Three Epstein-Barr virus-associated smooth muscle tumors (intracranial, endobronchial, and paraspinal) in 2 patients are presented. The patient with the intracranial tumor had no concurrent or previous manifestation of this neoplasm and was immunosuppressed because of a renal transplant. The other p
PMID 23022018

Gene expression signatures differentiate uterine endometrial stromal sarcoma from leiomyosarcoma.

Davidson B, Abeler VM, Hellesylt E, Holth A, Shih IeM, Skeie-Jensen T, Chen L, Yang Y, Wang TL.SourceDepartment of Pathology, Norwegian Radium Hospital, Oslo University Hospital, N-0424 Oslo, Norway; The Medical Faculty, University of Oslo, N-0316 Oslo, Norway. Electronic address: bend@medisin.uio.no.
Gynecologic oncology.Gynecol Oncol.2013 Feb;128(2):349-55. doi: 10.1016/j.ygyno.2012.11.021. Epub 2012 Nov 21.
OBJECTIVE: Endometrial stromal sarcoma (ESS) and leiomyosarcoma (LMS) are the two most common uterine sarcomas, but both are rare tumors. The aim of the present study was to compare the global gene expression patterns of ESS and LMS.METHODS: Gene expression profiles of 7 ESS and 13 LMS were analyzed
PMID 23178314

Japanese Journal

Douglas窩に生じた脂肪平滑筋腫の1例

日本臨床外科学会雑誌 75(11), 3164-3168, 2014
NAID 130005072872

肝および副腎合併切除を行った下大静脈原発平滑筋肉腫の1例

日本臨床外科学会雑誌 75(5), 1208-1212, 2014
NAID 130004706264

特徴的な経過を呈した子宮筋腫肺転移の2例

日本臨床外科学会雑誌 = The journal of the Japan Surgical Association 74(9), 2428-2433, 2013-09-25
NAID 10031203131

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リンク元	「calmodulin-binding protein」「カルデスモン」

「calmodulin-binding protein」

Caldesmon 1
Identifiers
Symbols	CALD1 ; CDM; H-CAD; HCAD; L-CAD; LCAD; NAG22
External IDs	OMIM: 114213 HomoloGene: 137424 GeneCards: CALD1 Gene
Gene ontology
Molecular function	• actin binding; • calmodulin binding; • tropomyosin binding; • myosin binding;
Cellular component	• cytosol; • cytoskeleton; • plasma membrane; • actin cytoskeleton; • myofibril; • actin cap;
Biological process	• movement of cell or subcellular component; • muscle contraction;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
	v; t; e;