calcium-calmodulin-dependent protein kinase

出典: meddic


calmodulin kinasecalmodulin-dependent protein kinase

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/01/10 10:03:01」(JST)

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  • Altered expression of neuroplasticity-related genes in the brain of depressed suicides.
  • Fuchsova B1, Alvarez Juliá A2, Rizavi HS3, Frasch AC2, Pandey GN3.
  • Neuroscience.Neuroscience.2015 Jul 23;299:1-17. doi: 10.1016/j.neuroscience.2015.04.057. Epub 2015 Apr 28.
  • BACKGROUND: Expression of the neuronal membrane glycoprotein M6a (GPM6A), the proteolipid protein (PLP/DM20) family member, is downregulated in the hippocampus of chronically stressed animals. Its neuroplastic function involves a role in neurite formation, filopodium outgrowth and synaptogenesis thr
  • PMID 25934039
  • Alterations in left ventricular function during intermittent hypoxia: Possible involvement of O-GlcNAc protein and MAPK signaling.
  • Guo X1, Shang J1, Deng Y1, Yuan X1, Zhu D1, Liu H1.
  • International journal of molecular medicine.Int J Mol Med.2015 Jul;36(1):150-8. doi: 10.3892/ijmm.2015.2198. Epub 2015 Apr 24.
  • Obstructive sleep apnea, characterized by recurrent episodes of hypoxia [intermittent hypoxia (IH)], has been identified as a risk factor for cardiovascular diseases. The O-linked β-N-acetylglucosamine (O-GlcNAc) modification (O-GlcNAcylation) of proteins has important regulatory implications on t
  • PMID 25936416
  • PDZ Domain in the Engineering and Production of a Saporin Chimeric Toxin as a Tool for targeting Cancer Cells.
  • Giansanti F1, Sabatini D1, Pennacchio MR1, Scotti S1, Angelucci F1, Dhez AC1, Antonosante A1, Cimini A1,2, Giordano A3,2, Ippoliti R1.
  • Journal of cellular biochemistry.J Cell Biochem.2015 Jul;116(7):1256-66. doi: 10.1002/jcb.25080.
  • In this paper we have studied a PDZ protein domain as a possible tool for cellular targeting of the ribosome inactivating protein Saporin, exploiting the ability of PDZ domains to recognize and bind short peptide sequences located at the C-terminus of a cognate protein. We have focused our attention
  • PMID 25581839


  • Can intermediate-frequency magnetic fields affect memory function-related gene expressions in hippocampus of C57BL/6J mice?
  • Win-Shwe Tin-Tin,Ohtani Shin,Ushiyama Akira,Fujimaki Hidekazu,Kunugita Naoki
  • The Journal of Toxicological Sciences 38(2), 169-176, 2013
  • … The relative mRNA expression levels of the N-methyl-D aspartate (NMDA) receptor subunits NR1, NR2A, and NR2B as well as transcription factors (calcium/calmodulin-dependent protein kinase (CaMK) -IV, cyclic AMP responsive element binding protein (CREB) -1) and neurotrophins (nerve growth factor (NGF), and brain-derived neurotrophic factors (BDNF)) were not significantly altered in the IF-MF-exposed mice. …
  • NAID 130004447032
  • CREB activation is a key player for ischemic tolerance in the brain
  • 北川 一夫,佐々木 勉,寺崎 泰和,八木田 佳樹,望月 秀樹
  • 臨床神経学 52(11), 904-907, 2012
  • … Then, influx of calcium ions into intracellular space activates calcium-calmodulin dependent protein kinase (CaMK). … CaMK I/IV phosphorylates Ser 133 of CREB, and Thr 484 of salt-inducible kinase (SIK). …
  • NAID 130004505204
  • P1-018  ループス腎炎のメサンギウム細胞におけるCalcium/calmodulin-dependent protein kinase type IVの役割
  • 一瀬 邦弘,川上 純,George C. Tsokos
  • 日本臨床免疫学会会誌 35(4), 335b-335b, 2012
  • …   〈目的〉全身性エリテマトーデス(SLE)に合併した腎病変は未だに死因の主要因となっている.SLEのT細胞ではCalcium/calmodulin-dependent protein Kinase Type IV (CaMKIV)の発現が増加しており,T細胞機能の異常を引き起こすことが報告されている.そこで我々はSLEのモデルマウスであるMRL/lprマウスを用いて,CaMKIVの腎臓メサンギウム細胞の機能制御 …
  • NAID 130003364055


The calcium/calmodulin-dependent kinases (CaMKs) are involved in a large number of cellular responses induced by hormones, neurotransmitters and other signalling. Elevation of calcium functions as a major second messenger ...
... kinase that had switch-like properties (Miller and Kennedy, 1986) was met with great enthusiasm, and the role of calcium/calmodulin-dependent protein kinase II (CaMKII) in learning and memory has been Previous Section ...



リンク元calmodulin-dependent protein kinase」「カルシウム・カルモジュリン依存性プロテインキナーゼ」「calmodulin kinase」「カルシウムカルモジュリン依存性キナーゼ
拡張検索calcium-calmodulin-dependent protein kinase type 2」「calcium-calmodulin-dependent protein kinase type 1」「calcium-calmodulin-dependent protein kinase type 4」「calcium-calmodulin-dependent protein kinase kinase

calmodulin-dependent protein kinase」



calcium-calmodulin-dependent protein kinasecalmodulin kinaseCaM kinaseCaMK



calcium-calmodulin-dependent protein kinase

calmodulin kinase」



calcium-calmodulin-dependent protein kinasecalmodulin-dependent protein kinaseCaM kinaseCaMK



calcium-calmodulin-dependent protein kinase

calcium-calmodulin-dependent protein kinase type 2」


calmodulin-dependent protein kinase II、CaM KII、CaM kinase IICaMKII

calcium-calmodulin-dependent protein kinase type 1」


calmodulin-dependent protein kinase ICaM kinase I

calcium-calmodulin-dependent protein kinase type 4」


calmodulin-dependent protein kinase IV

calcium-calmodulin-dependent protein kinase kinase」





  • adj.
  • 依存性の、依存的な、依存型の、依存の

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「relying on or requiring a person or thing for support, supply, or what is needed; "dependent children"; "dependent on moisture"」

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「『頼っている』,依存している,従属している / 扶養される人(家族)」

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「addicted to a drug」
dependant, drug-addicted, hooked, strung-out

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「contingent on something else」
dependant, qualified

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「(of a clause) unable to stand alone syntactically as a complete sentence; "a subordinate (or dependent) clause functions as a noun or adjective or adverb within a sentence"」


  [★] 蛋白質

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「any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high in protein"」

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「a white metallic element that burns with a brilliant light; the fifth most abundant element in the earth''s crust; an important component of most plants and animals」
Ca, atomic number 20

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  [★] キナーゼ カイネース リン酸化酵素 phosphoenzyme phosphotransferase

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「an enzyme that catalyzes the conversion of a proenzyme to an active enzyme」



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「the basic unit of money in Papua New Guinea」