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1. 心筋障害のバイオマーカーとしてのトロポニンおよびクレアチンキナーゼ troponins and creatine kinase as biomarkers of cardiac injury
2. 急性冠症候群がない患者にでの心筋トロポニン濃度の上昇 elevated cardiac troponin concentration in the absence of an acute coronary syndrome
3. 腎不全患者における血清心筋酵素 serum cardiac enzymes in patients with renal failure
4. トロポニンおよびクレアチンキナーゼ以外の心筋障害のバイオマーカー biomarkers of cardiac injury other than troponins and creatine kinase
5. 乳幼児および小児における心不全の病因および診断 etiology and diagnosis of heart failure in infants and children

English Journal

The use of antibody modified liposomes loaded with AMO-1 to deliver oligonucleotides to ischemic myocardium for arrhythmia therapy.

Liu M1, Li M1, Sun S1, Li B2, Du D1, Sun J2, Cao F1, Li H1, Jia F3, Wang T3, Chang N1, Yu H1, Wang Q4, Peng H5.Author information 1Department of Pharmaceutics, Daqing Campus of Harbin Medical University, Daqing 163319, China.2Department of Pharmaceutics, Harbin Medical University, Harbin 150086, China.3Department of Chemical and Biological Engineering, Ames, IA 50011, USA.4Department of Chemical and Biological Engineering, Ames, IA 50011, USA; Department of Civil, Construction and Environmental Engineering, Iowa State University, Ames, IA 50011, USA.5Department of Pharmaceutics, Daqing Campus of Harbin Medical University, Daqing 163319, China; Department of Chemical and Biological Engineering, Ames, IA 50011, USA. Electronic address: fisher1688@163.com.AbstractMicroRNA-1 (miR-1) has been found in cardiac and skeletal tissues. It is overexpressed in ischemic cardiac tissues. Down-regulation of miR-1 could relieve arrhythmogenesis by the anti-miR-1 antisense oligonucleotides (AMO-1). To increase the therapeutic efficiency and inhibit off-target effects of AMO-1, here we explored anti-cardiac troponin I (cTnI) antibody modified liposomes loading with AMO-1 (cT-A-LIP) to deliver the oligonucleotides to ischemic myocardium tissues. Liposomal cytotoxicity was assessed by MTT assay. The targeting abilities to foci were evaluated by in vivo imaging. The uptake and bio-distribution in vitro were observed by live cell station and flow cytometry, respectively. The anti-arrhythmic effects of cT-A-LIP in vivo were evaluated by electrocardiograms (ECG), immunohistochemistry, real-time PCR and patch-clamp recording. Immunohistochemistry showed that cTnI expression had a peak at the third day after myocardial infarction (MI). After cT-LIP administration via tail vein, accumulation of fluorescent trackers in the ischemic foci was significantly increased more than that of LIP. In addition, after cT-A-LIP administration, the ischemic arrhythmias were recovered and ST segment in ECG was elevated nearly back to normal. Compared with MI group, miR-1 expression was significantly down-regulated while Kir2.1 and CX43 protein expression were increased. Patch-clamp recordings showed that cT-A-LIP as well as AMO-1 incubation increased K(+) current density in guinea pigs ventricular cardiomyocytes acting on repolarized membrane potential. In conclusion, the cT-A-LIP not only delivered AMO-1 to ischemic myocardium in MI rats, but validated AMO-1 on relieving ischemic arrhythmia by silencing of miR-1 in ischemic myocardium and restoring the depolarized resting membrane potential (RMP) in MI rats.
Biomaterials.Biomaterials.2014 Apr;35(11):3697-707. doi: 10.1016/j.biomaterials.2013.12.099. Epub 2014 Jan 24.
MicroRNA-1 (miR-1) has been found in cardiac and skeletal tissues. It is overexpressed in ischemic cardiac tissues. Down-regulation of miR-1 could relieve arrhythmogenesis by the anti-miR-1 antisense oligonucleotides (AMO-1). To increase the therapeutic efficiency and inhibit off-target effects of A
PMID 24468403

How can we make measures of psychotic depression symptoms more clinically useful?

Fava M.
Acta psychiatrica Scandinavica.Acta Psychiatr Scand.2014 Mar;129(3):161-2. doi: 10.1111/acps.12177. Epub 2013 Jul 22.
PMID 23869739

Peri-operative troponin monitoring using a prototype high-sensitivity cardiac troponin I (hs-cTnI) assay: comparisons with hs-cTnT and contemporary cTnI assays.

Lee GR, Jhanji S, Tarrant H, James S, Pearse RM, Fitzgibbon M.Author information Department of Clinical Biochemistry and Diagnostic Endocrinology, Mater Misericordiae University Hospital, Dublin, Republic of Ireland.AbstractBACKGROUND: Non-cardiac surgery is associated with major vascular complications and higher incidences of elevated plasma troponin (cTn) concentration. Goal-directed therapy (GDT) is a stroke volume (SV)-guided approach to intravenous (IV) fluid therapy that improves tissue perfusion, oxygenation and reduces post-operative complications. In patients undergoing major gastro-intestinal surgery, we compared high sensitive and contemporary troponin assays and correlated results with patient outcome.
Annals of clinical biochemistry.Ann Clin Biochem.2014 Mar;51(Pt 2):258-68. doi: 10.1177/0004563213494078. Epub 2013 Sep 18.
BACKGROUND: Non-cardiac surgery is associated with major vascular complications and higher incidences of elevated plasma troponin (cTn) concentration. Goal-directed therapy (GDT) is a stroke volume (SV)-guided approach to intravenous (IV) fluid therapy that improves tissue perfusion, oxygenation and
PMID 24048718

Japanese Journal

Nonculprit Lesion Progression in Patients With ST Elevation Myocardial Infarction After Primary Percutaneous Coronary Intervention

Wang Jian,Liu Jing-hua,Zhu Xiao-ling,Zhang Ming,Wang Shao-ping,Zheng Ze
International Heart Journal 55(1), 48-52, 2014
… 0.0001, cTnI peak value (27.27 ± 4.02) ng/mL versus (16.12 ± 3.23) ng/mL, <I>P</I> …
NAID 130003392052

Heart extracellular matrix supports cardiomyocyte differentiation of mouse embryonic stem cells(CELL AND TISSUE ENGINEERING)

Higuchi Sayaka,Lin Qingsong,Wang Jigang [他],Lim Teck Kwang,Joshi Shashikant B.,Anand Ganesh Srinivasan,Chung Maxey C.M.,Sheetz Michael P.,Fujita Hideaki
Journal of bioscience and bioengineering 115(3), 320-325, 2013-03
… When mouse ES cells were cultured on thin (60 μm) sections of de-cellularized tissue, the expression of cardiac myosin heavy chain (cMHC) and cardiac troponin I (cTnI) was high in ES cells cultured on heart ECM compared with those cultured on liver ECM. … In addition, the protein expression of cMHC and cTnI was detected in cells on heart ECM after 2 weeks, which was not detectable in cells on liver ECM. …
NAID 110009596108

Usefulness of Serum Cardiac Troponins T and I to Predict Cardiac Molecular Changes and Cardiac Damage in Patients With Hypertrophic Cardiomyopathy

Okamoto Rie,Hirashiki Akihiro,Cheng Xian Wu,Yamada Takashi,Shimazu Shuzo,Shinoda Norihiro,Okumura Takahiro,Takeshita Kyosuke,Bando Yasuko,Kondo Takahisa,Murohara Toyoaki
International Heart Journal 54(4), 202-206, 2013
… We sought to investigate the associations between elevated serum cardiac troponins T (cTnT) and I (cTnI) levels and cardiac injury in patients with HCM. … We measured serum cTnT and cTnI in a peripheral vein of 73 consecutive HCM patients in stable condition. … In addition, to examine the transcardiac release of cTnT and that of cTnI, we measured them in the aortic root and coronary sinus. …
NAID 130003364470