cAMP-dependent protein kinase

出典: meddic

A-kinasecyclic AMP-dependent protein kinasePKAprotein kinase A

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/05/18 12:54:44」(JST)

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  • Caffeine stimulates locomotor activity in the mammalian spinal cord via adenosine A1 receptor-dopamine D1 receptor interaction and PKA-dependent mechanisms.
  • Acevedo J1, Santana-Almansa A1, Matos-Vergara N1, Marrero-Cordero LR1, Cabezas-Bou E1, Díaz-Ríos M2.
  • Neuropharmacology.Neuropharmacology.2016 Feb;101:490-505. doi: 10.1016/j.neuropharm.2015.10.020. Epub 2015 Oct 19.
  • Caffeine is a potent psychostimulant that can have significant and widely variable effects on the activity of multiple neuronal pathways. The most pronounced caffeine-induced behavioral effect seen in rodents is to increase locomotor activity which has been linked to a dose-dependent inhibition of A
  • PMID 26493631
  • Role of phosphodiesterase-4 on ethanol elicited locomotion and narcosis.
  • Baliño P1, Ledesma JC2, Aragon CM3.
  • Neuropharmacology.Neuropharmacology.2016 Feb;101:271-8. doi: 10.1016/j.neuropharm.2015.10.001. Epub 2015 Oct 9.
  • The cAMP signaling pathway has emerged as an important modulator of the pharmacological effects of ethanol. In this respect, the cAMP-dependent protein kinase has been shown to play an important role in the modulation of several ethanol-induced behavioral actions. Cellular levels of cAMP are maintai
  • PMID 26449868
  • Effects of ketamine administration on the phosphorylation levels of CREB and TrKB and on oxidative damage after infusion of MEK inhibitor.
  • Réus GZ1, Abaleira HM2, Titus SE2, Arent CO3, Michels M4, da Luz JR3, Dos Santos MA3, Carlessi AS3, Matias BI3, Bruchchen L3, Steckert AV3, Ceretta LB5, Dal-Pizzol F4, Quevedo J6.
  • Pharmacological reports : PR.Pharmacol Rep.2016 Feb;68(1):177-84. doi: 10.1016/j.pharep.2015.08.010. Epub 2015 Aug 28.
  • BACKGROUND: Ketamine, an antagonist of N-methyl-d-aspartate (NMDA) receptors, has presented antidepressant effects in basic and clinical studies. The MAPK kinase (MEK) signaling pathway could be a target for novel antidepressant drugs and an important pathway involved in neuronal plasticity. Thus, t
  • PMID 26721370


  • プロスタグランディンE_2-Epacシグナルによるラット動脈管の内膜肥厚形成の促進作用(2009年度受賞者,粟山煕賞受賞講演,第52回日本平滑筋学会総会)
  • 横山 詩子,南沢 享,石川 義弘
  • 日本平滑筋学会雑誌 14(1), "J-4", 2010-06-11
  • NAID 110007643164
  • Dipyridamole Suppresses High Glucose-Induced Osteopontin Secretion and mRNA Expression in Rat Aortic Smooth Muscle Cells
  • HSIEH Ming-Song,ZHONG Wen-Bin,YU Shu-Chuan,LIN John Yi-Chung,CHI Wei-Ming,LEE Horng-Mo
  • Circulation journal : official journal of the Japanese Circulation Society 74(6), 1242-1250, 2010-05-25
  • … Methods and Results: The incubation of rat aortic smooth muscle cells under high glucose concentration increased osteopontin protein secretion and mRNA expression. … Dipyridamole decreased glucose-induced osteopontin through inhibition of phosphodiesterase, thereby increasing intracellular levels of adenosine-3,5-cyclic monophosphate (cAMP) and guanosine-3,5-cyclic monophosphate (cGMP), and increased thioredoxin expression to inhibit the reactive oxygen species (ROS) system. …
  • NAID 10026475114


References D. A. Johnson, P. Akamine, E. Radzio-Andzelm, Madhusudan & S. S. Taylor (2001) Dynamics of cAMP-dependent protein kinase. Chemical Reviews 101, 2243-2270. S. S. Taylor, C. Kim, D. Vigil, N. M. Haste, J. Yang ...
この精製された40kDaのcAMP-Dependent Protein Kinase(PKA),Catalytic Subunitは 標的タンパク質のリン酸化や、in vitroでの神経性およびホルモン性シグナル伝達における酵素学的研究に使用されます。細胞内の標的として、イオン ...


cAMP-dependent protein kinase. Causes Camp-dependent Protein Kinase Pka,Type Ii CAMP Dependent Protein Kinase, Catalytic cAMP dependent protein kinase, cAPKcAMP-dependent protein kinase. Causes cAMP-dependent protein kinase molecule

先読みcyclic AMP-dependent protein kinase」「protein kinase A

cyclic AMP-dependent protein kinase」

  [★] プロテインキナーゼA

See Protein kinases

protein kinase A」





cyclic AMP-dependent protein kinasecAMP-dependent protein kinaseprotein kinase APKA



cAMP-dependent protein kinaseprotein kinase AA-kinase



A-kinasecAMP-dependent protein kinasecyclic AMP-dependent protein kinaseprotein kinase A
See Protein kinase A
Protein kinase A




cAMP-dependent protein kinasePKAprotein kinase A



cAMP-dependent protein kinase



WordNet   license wordnet

「give an artificially banal or sexual quality to」

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「temporary living quarters specially built by the army for soldiers; "wherever he went in the camp the men were grumbling"」
encampment, cantonment, bivouac

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「shelter for persons displaced by war or political oppression or for religious beliefs」
refugee camp

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「a site where care and activities are provided for children during the summer months; "city kids get to see the country at a summer camp"」
summer camp

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「a penal institution (often for forced labor); "China has many camps for political prisoners"」

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「temporary lodgings in the country for travelers or vacationers; "level ground is best for parking and camp areas"」

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「a group of people living together in a camp; "the whole camp laughed at his mistake"」

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「something that is considered amusing not because of its originality but because of its unoriginality; "the living room was pure camp"」

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「〈C〉(軍隊・登山隊・探検隊などの)『野営地』 / 〈C〉〈U〉野営のテント,仮設小屋 / 〈U〉野営,キャンプ[生活];軍隊生活 / 〈C〉夏季キャンプ場,サマーキャンプ / 《集合的に》野営する人たち,キャンプする人たち / 〈C〉(主義・信条などを同じくする)同志たち,同じ陣営;同じ立場 / 『野営する』,キャンプ生活を送る《+『out』》」

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「=homosexual / (男性が)女々しい / すたれた,古めかしい」

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「establish or set up a camp」
camp down

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「providing sophisticated amusement by virtue of having artificially (and vulgarly) mannered or banal or sentimental qualities; "they played up the silliness of their roles for camp effect"; "campy Hollywood musicals of the 1940''s"」

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「live in or as if in a tent; "Can we go camping again this summer?"; "The circus tented near the town"; "The houseguests had to camp in the living room"」
encamp, camp out, bivouac, tent



  • adj.
  • 依存性の、依存的な、依存型の、依存の

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「relying on or requiring a person or thing for support, supply, or what is needed; "dependent children"; "dependent on moisture"」

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「『頼っている』,依存している,従属している / 扶養される人(家族)」

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「addicted to a drug」
dependant, drug-addicted, hooked, strung-out

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「contingent on something else」
dependant, qualified

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「(of a clause) unable to stand alone syntactically as a complete sentence; "a subordinate (or dependent) clause functions as a noun or adjective or adverb within a sentence"」


  [★] 蛋白質

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「any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high in protein"」

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  [★] キナーゼ カイネース リン酸化酵素 phosphoenzyme phosphotransferase

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「an enzyme that catalyzes the conversion of a proenzyme to an active enzyme」


  [★] 環状アデノシン一リン酸 サイクリックAMP 環状AMP adenosine 3',5'-cyclic monophosphate, cyclic AMP