関: butaclamol hydrochloride

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/06/25 14:12:36」(JST)

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Butaclamol (AY-23,028) is an antipsychotic which was never marketed.^[1] Sold as the hydrochloride salt for use in research, the compound acts as a dopamine receptor antagonist. ^[2]

Chemistry

pK_a = 7.15 (uncorrected for ionic strength)^[3]

References

^ Dictionary of organic compounds - Google Books.
^ http://www.sigmaaldrich.com/catalog/ProductDetail.do?D7=0&N5=SEARCH_CONCAT_PNO%7CBRAND_KEY&N4=D033%7CSIGMA&N25=0&QS=ON&F=SPEC
^ F. A. Chrzanowski, B. A. McGrogan, B. E. Maryanoff (1985). "The pKa of butaclamol and the mode of butaclamol binding to central dopamine receptors." J. Med. Chem. 28 399-400.

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English Journal

Examining the Effects of Sodium Ions on the Binding of Antagonists to Dopamine D2 and D3 Receptors.

Newton CL1, Wood MD2, Strange PG1.
PloS one.PLoS One.2016 Jul 5;11(7):e0158808. doi: 10.1371/journal.pone.0158808. eCollection 2016.
PMID 27379794

The Ascaris suum nicotinic receptor, ACR-16, as a drug target: Four novel negative allosteric modulators from virtual screening.

Zheng F1, Robertson AP2, Abongwa M2, Yu EW3, Martin RJ2.
International journal for parasitology. Drugs and drug resistance.Int J Parasitol Drugs Drug Resist.2016 Feb 10;6(1):60-73. doi: 10.1016/j.ijpddr.2016.02.001. eCollection 2016 Apr.
PMID 27054065

Dopamine and T cells: dopamine receptors and potent effects on T cells, dopamine production in T cells, and abnormalities in the dopaminergic system in T cells in autoimmune, neurological and psychiatric diseases.

Levite M1,2,3.
Acta physiologica (Oxford, England).Acta Physiol (Oxf).2016 Jan;216(1):42-89. doi: 10.1111/apha.12476. Epub 2015 Sep 24.
PMID 25728499

Japanese Journal

Modulation of Adenylyl Cyclase Activity in Rat Striatal Homogenate by Dopaminergic Receptors

Vonk Argo,Reinart Reet,Rinken Ago
Journal of pharmacological sciences 108(1), 63-70, 2008-09-20
… All D1-receptor agonists (dopamine, dihydrexidine, and A 77636) used were able to increase cAMP accumulation in a concentration-dependent manner, while D1-receptor antagonists (SCH23390, SKF83566, and butaclamol) blocked the effects induced by the aforementioned agonists. …
NAID 10024322411

Evidence for the presence of D2 and 5-HT2 receptors in the human prefrontal cortex.

Mita Tatsuo [他],KUNO Takayoshi,NAKAI Hisao,TANAKA Chikako
The Japanese Journal of Pharmacology 32(6), 1027-1032, 1982
… In the Scatchard analysis of stereoselective binding defined by (+) and (-)-butaclamol, two high affinity binding sites were clearly demonstrated. …
NAID 130000835419

Related Pictures

★リンクテーブル★

リンク元	「ブタクラモール」
拡張検索	「butaclamol hydrochloride」

「ブタクラモール」

Butaclamol
Systematic (IUPAC) name
	3-(1,1-dimethylethyl)-2,3,4,4a,8,9, 13b,14-octahydro-1H-benzo[6,7]cyclohepta[1,2,3-de]pyrido[2,1-a]isoquinolin-3-ol
Clinical data
Legal status	?
Identifiers
CAS number	36504-93-5
ATC code	None
PubChem	CID 37459
IUPHAR ligand	62
ChemSpider	34364
UNII	A7A2802VNL
ChEBI	CHEBI:73298
ChEMBL	CHEMBL479587
Chemical data
Formula	C25H31NO
Mol. mass	361.52 g/mol
	SMILES CC(C)(C)C1(CCN2CC3C4=CC=CC=C4CCC5=C3C(=CC=C5)C2C1)O;