burn-wound infections

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英文文献

  • Call for a dedicated European legal framework for bacteriophage therapy.
  • Verbeken G1, Pirnay JP, Lavigne R, Jennes S, De Vos D, Casteels M, Huys I.Author information 1Laboratory for Molecular and Cellular Technology, Burn Wound Centre, Queen Astrid Military Hospital, Brussels, Belgium, gilbert.verbeken@mil.be.AbstractThe worldwide emergence of antibiotic resistances and the drying up of the antibiotic pipeline have spurred a search for alternative or complementary antibacterial therapies. Bacteriophages are bacterial viruses that have been used for almost a century to combat bacterial infections, particularly in Poland and the former Soviet Union. The antibiotic crisis has triggered a renewed clinical and agricultural interest in bacteriophages. This, combined with new scientific insights, has pushed bacteriophages to the forefront of the search for new approaches to fighting bacterial infections. But before bacteriophage therapy can be introduced into clinical practice in the European Union, several challenges must be overcome. One of these is the conceptualization and classification of bacteriophage therapy itself and the extent to which it constitutes a human medicinal product regulated under the European Human Code for Medicines (Directive 2001/83/EC). Can therapeutic products containing natural bacteriophages be categorized under the current European regulatory framework, or should this framework be adapted? Various actors in the field have discussed the need for an adapted (or entirely new) regulatory framework for the reintroduction of bacteriophage therapy in Europe. This led to the identification of several characteristics specific to natural bacteriophages that should be taken into consideration by regulators when evaluating bacteriophage therapy. One important consideration is whether bacteriophage therapy development occurs on an industrial scale or a hospital-based, patient-specific scale. More suitable regulatory standards may create opportunities to improve insights into this promising therapeutic approach. In light of this, we argue for the creation of a new, dedicated European regulatory framework for bacteriophage therapy.
  • Archivum immunologiae et therapiae experimentalis.Arch Immunol Ther Exp (Warsz).2014 Apr;62(2):117-29. doi: 10.1007/s00005-014-0269-y. Epub 2014 Feb 6.
  • The worldwide emergence of antibiotic resistances and the drying up of the antibiotic pipeline have spurred a search for alternative or complementary antibacterial therapies. Bacteriophages are bacterial viruses that have been used for almost a century to combat bacterial infections, particularly in
  • PMID 24500660
  • Enhancement of the antimicrobial properties of Bacteriophage-K via Stabilisation using Oil-in-Water Nano-emulsions.
  • Esteban PP1, Alves DR, Enright MC, Gaudion A, Jenkins AT, Young AE, Arnot TC.Author information 1Department of Chemical Engineering, University of Bath, Claverton Down, Bath, BA2 7AY, UK; Department of Chemistry, University of Bath, Claverton Down, Bath, BA2 7AY, UK.AbstractBacteriophage therapy is a promising new treatment that may help overcome the threat posed by antibiotic-resistant pathogenic bacteria, which are increasingly identified in hospitalised patients. The development of biocompatible and sustainable vehicles for incorporation of viable bacterial viruses into a wound dressing is a promising alternative. This paper evaluates the anti-microbial efficacy of Bacteriophage K against Staphylococcus aureus over time, when stabilised and delivered via an oil-in-water nano-emulsion. Nano-emulsions were formulated via thermal phase inversion emulsification, and then bacterial growth was challenged with either native emulsion, or emulsion combined with Bacteriophage K. Bacteriophage infectivity, and the influence of storage time of the preparation, were assessed by turbidity measurements of bacterial samples. Newly prepared Bacteriophage K / nano-emulsion formulations have greater anti-microbial activity than freely suspended bacteriophage. The phage loaded emulsions caused rapid and complete bacterial death of three different strains of Staphylococcus aureus. The same effect was observed for preparations that were either stored at room temperature (18 - 20°C), or chilled at 4°C, for up to 10 days of storage. A response surface design of experiments was used to gain insight on the relative effects of the emulsion formulation on bacterial growth and phage lytic activity. More diluted emulsions had a less significant effect on bacterial growth, and diluted bacteriophage-emulsion preparations yielded greater antibacterial activity. The enhancement of bacteriophage activity when delivered via nano-emulsions has yet to be reported. This prompts further investigation into the use of these formulations for the development of novel anti-microbial wound management strategies. © 2014 American Institute of Chemical Engineers Biotechnol. Prog., 2014.
  • Biotechnology progress.Biotechnol Prog.2014 Mar 10. doi: 10.1002/btpr.1899. [Epub ahead of print]
  • Bacteriophage therapy is a promising new treatment that may help overcome the threat posed by antibiotic-resistant pathogenic bacteria, which are increasingly identified in hospitalised patients. The development of biocompatible and sustainable vehicles for incorporation of viable bacterial viruses
  • PMID 24616410

和文文献

  • 感染対策 (特集 熱傷診療ガイドライン--その読み方と活用法)
  • 重症熱傷に合併したMRSA感染症に対する十全大補湯の使用経験
  • 中永 士師明,松永 直子
  • 日本東洋醫學雜誌 58(6), 1127-1131, 2007-11-20
  • 重症熱傷が長期化した場合は創部へのMRSAの感染はもとより肺炎,尿路感染,カテーテル感染などを合併し治療に難渋することがある。補剤には免疫機構の活性化が期待されるが,重症熱傷に合併したMRSA感染症に対して補剤を使用した報告はほとんどない。今回,2例のMRSA感染症に対して十全大補湯を使用し良好な結果を得たので報告する。[症例1]34歳,男性。自殺企図にて灯油を頭からかぶり火をつけて85%の火炎熱 …
  • NAID 110006474661
  • Efficacy of gaseous nitric oxide in the treatment of skin and soft tissue infections
  • GHAFFARI Abdi,JALILI Reza,GHAFFARI Mazyar,MILLER Chris,GHAHARY Aziz
  • Wound
  • NAID 10031181357

関連リンク

Division of Microbiology, Calgary Laboratory Services, 1 Departments of Pathology & Laboratory Medicine, 2 Surgery, 3 Critical Care, Calgary Health Region and University ... Corresponding author. Mailing address: Calgary ...
SUMMARY Burns are one of the most common and devastating forms of trauma. Patients with serious thermal injury require immediate specialized care in order to minimize morbidity and mortality. Significant thermal ...

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The Introduction of a Protocol for the Use Infected Burn Wound II by StageArtisan on  Burn-Wound Infection | The Water AwarenessTreating infection in burns | Contemporary Burn wound infection, hand burns, second  Be Effective in Treating Wound Infections


★リンクテーブル★
関連記事burn」「wound」「infection」「burning」「burned

burn」

  [★]

  • n.

WordNet   license wordnet

「spend (significant amounts of money); "He has money to burn"」

WordNet   license wordnet

「pain that feels hot as if it were on fire」
burning

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「undergo combustion; "Maple wood burns well"」
combust

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「destroy by fire; "They burned the house and his diaries"」
fire, burn down

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「cause to undergo combustion; "burn garbage"; "The car burns only Diesel oil"」
incinerate

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「an injury caused by exposure to heat or chemicals or radiation」

WordNet   license wordnet

「burn with heat, fire, or radiation; "The iron burnt a hole in my dress"」

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「a place or area that has been burned (especially on a person''s body)」
burn mark

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「damage inflicted by fire」

PrepTutorEJDIC   license prepejdic

「〈火・家などが〉『燃える』,『焼ける』 / (火や熱によって)『焦げる』,日焼けする / 『光』(『熱』)『を出す』 / (…で)熱さを感じる,ほてる《+『with』+『名』》 / (愛憎などで)燃える,かっかとなる《+『with』+『名』》 / …'を'『燃やす』,『焼く』 / …'を'焦がす;…'を'日焼けさせる / …'を'熱く感じさせる,'を'ほてらせる / …'を'燃料にする / 『やけど』;焼け焦げ / 『日焼け』 / ロケットの噴射・(CDなどに)焼く、(音楽{おんがく}やデータなどを)(CDなどに)焼く」

PrepTutorEJDIC   license prepejdic

「《スコットランド》小川」

WordNet   license wordnet

「cause to burn or combust; "The sun burned off the fog"; "We combust coal and other fossil fuels"」
combust

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「shine intensely, as if with heat; "The coals were glowing in the dark"; "The candles were burning"」
glow

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「burn at the stake; "Witches were burned in Salem"」

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「feel hot or painful; "My eyes are burning"」

WordNet   license wordnet

「feel strong emotion, especially anger or passion; "She was burning with anger"; "He was burning to try out his new skies"」

wound」

  [★]

  • n.
bruisehurtinjurytraumatraumatizeundermine

WordNet   license wordnet

「put in a coil」

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「an injury to living tissue (especially an injury involving a cut or break in the skin)」
lesion

WordNet   license wordnet

「the act of inflicting a wound」
wounding

WordNet   license wordnet

「a casualty to military personnel resulting from combat」
injury, combat injury

WordNet   license wordnet

「a figurative injury (to your feelings or pride); "he feared that mentioning it might reopen the wound"; "deep in her breast lives the silent wound"; "The right reader of a good poem can tell the moment it strikes him that he has taken an immortal wound--t」

PrepTutorEJDIC   license prepejdic

「windの過去・過去分詞」

PrepTutorEJDIC   license prepejdic

「(身体の)『傷』,負傷 / (感情・自尊心などに対する)『痛手』,傷《+to+『名』》 / …‘を'『負傷させる』 / 〈感情など〉‘を'傷つける,〈人〉‘の'感情などを傷つける」


infection」

  [★]

  • n.
contagioninfectinfectious diseaseinfestationtransmissiontransmit

WordNet   license wordnet

「(medicine) the invasion of the body by pathogenic microorganisms and their multiplication which can lead to tissue damage and disease」

WordNet   license wordnet

「(phonetics) the alteration of a speech sound under the influence of a neighboring sound」

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「the pathological state resulting from the invasion of the body by pathogenic microorganisms」

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「(international law) illegality that taints or contaminates a ship or cargo rendering it liable to seizure」

WordNet   license wordnet

「moral corruption or contamination; "ambitious men are led astray by an infection that is almost unavoidable"」

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「an incident in which an infectious disease is transmitted」
contagion, transmission

PrepTutorEJDIC   license prepejdic

「〈U〉(病気の)伝染;感染 / 〈C〉伝染病」


burning」

  [★]


WordNet   license wordnet

「of immediate import; "burning issues of the day"」

WordNet   license wordnet

「execution by fire」
burning at the stake

WordNet   license wordnet

「the act of burning something; "the burning of leaves was prohibited by a town ordinance"」
combustion

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「a form of torture in which cigarettes or cigars or other hot implements are used to burn the victim''s skin」

PrepTutorEJDIC   license prepejdic

「燃えている,焼けている / 燃えるように熱い;強烈な / 火急の,差し迫った」


burned」

  [★]

WordNet   license wordnet

「destroyed or badly damaged by fire; "a row of burned houses"; "a charred bit of burnt wood"; "a burned-over site in the forest"; "barricaded the street with burnt-out cars"」
burnt, burned-over, burned-out, burnt-out

WordNet   license wordnet

「ruined by overcooking; "she served us underdone bacon and burnt biscuits"」
burnt

WordNet   license wordnet

「treated by heating to a high temperature but below the melting or fusing point; "burnt sienna"」
burnt




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