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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/10/15 12:00:35」(JST)

English Journal

Repression of hepatic cytochrome P450 2D expression in mice during Babesia microti infection.

Shimamoto Y1, Watanabe K, Ikadai H, Okamura M, Ishizuka M.
The Journal of veterinary medical science / the Japanese Society of Veterinary Science.J Vet Med Sci.2014 Aug;76(8):1147-51. Epub 2014 May 1.
To examine the effect of Babesia infection on the level of the drug-metabolizing enzyme hepatic cytochrome P450 (CYP) 2D, we intraperitoneally inoculated Babesia microti into male ICR mice. CYP2D protein and CYP2D9 mRNA were significantly decreased at 12 days after infection with B. microti. The act
PMID 24784440

Impact of solvent conditions on separation and detection of basic drugs by micro liquid chromatography-mass spectrometry under overloading conditions.

Schubert B1, Oberacher H.
Journal of chromatography. A.J Chromatogr A.2011 Jun 3;1218(22):3413-22. doi: 10.1016/j.chroma.2011.03.051. Epub 2011 Mar 27.
In this study the impact of solvent conditions on the performance of μLC/MS for the analysis of basic drugs was investigated. Our aim was to find experimental conditions that enable high-performance chromatographic separation particularly at overloading conditions paired with a minimal loss of mass
PMID 21530972

Extrapolating in vitro metabolic interactions to isolated perfused liver: predictions of metabolic interactions between R-bufuralol, bunitrolol, and debrisoquine.

Haddad S1, Poulin P, Funk C.
Journal of pharmaceutical sciences.J Pharm Sci.2010 Oct;99(10):4406-26. doi: 10.1002/jps.22136.
Drug-drug interactions (DDIs) are a great concern to the selection of new drug candidates. While in vitro screening assays for DDI are a routine procedure in preclinical research, their interpretation and relevance for the in vivo situation still represent a major challenge. The objective of the pre
PMID 20310018

Repression of Hepatic Cytochrome P450 2D Expression in Mice during <i>Babesia microti</i> Infection

Changes in the Enzymatic Properties of CYP2D6 by the Substitution of Phenylalanine at Position 120 by Alanine

Alteration in Catalytic Properties of Human CYP2D6 Caused by Substitution of Glycine-42 with Arginine, Lysine and Glutamic Acid

Bunitrolol
Names
	IUPAC name 2-[3-(tert-Butylamino)-2-hydroxypropoxy]benzonitrile
Identifiers
CAS Registry Number	34915-68-9
ChEMBL	ChEMBL418134
ChemSpider	2379
	InChI InChI=1S/C14H20N2O2/c1-14(2,3)16-9-12(17)10-18-13-7-5-4-6-11(13)8-15/h4-7,12,16-17H,9-10H2,1-3H3; Key: VCVQSRCYSKKPBA-UHFFFAOYSA-N ; InChI=1/C14H20N2O2/c1-14(2,3)16-9-12(17)10-18-13-7-5-4-6-11(13)8-15/h4-7,12,16-17H,9-10H2,1-3H3; Key: VCVQSRCYSKKPBA-UHFFFAOYAU ;
Jmol-3D images	Image
PubChem	2473
	SMILES CC(C)(C)NCC(COC1=CC=CC=C1C#N)O ;
Properties
Chemical formula	C14H20N2O2
Molar mass	248.33 g·mol−1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
	Infobox references

Names

IUPAC name 2-[3-(tert-Butylamino)-2-hydroxypropoxy]benzonitrile
Identifiers
CAS Registry Number	34915-68-9
ChEMBL	ChEMBL418134
ChemSpider	2379
InChI InChI=1S/C14H20N2O2/c1-14(2,3)16-9-12(17)10-18-13-7-5-4-6-11(13)8-15/h4-7,12,16-17H,9-10H2,1-3H3 Key: VCVQSRCYSKKPBA-UHFFFAOYSA-N InChI=1/C14H20N2O2/c1-14(2,3)16-9-12(17)10-18-13-7-5-4-6-11(13)8-15/h4-7,12,16-17H,9-10H2,1-3H3 Key: VCVQSRCYSKKPBA-UHFFFAOYAU
Jmol-3D images	Image
PubChem	2473
SMILES CC(C)(C)NCC(COC1=CC=CC=C1C#N)O
Properties
Chemical formula	C₁₄H₂₀N₂O₂
Molar mass	248.33 g·mol⁻¹
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

リンク元	「ブニトロロール」
拡張検索	「bunitrolol hydrochloride」