bullous keratopathy

水疱性角膜症

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2012/07/31 13:15:39」(JST)

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Bullous keratopathy
Classification and external resources
ICD-10	H18.1
ICD-9	371.23
DiseasesDB	32601

Bullous keratopathy is a pathological condition in which small vesicles, or bullae, are formed in the cornea due to endothelial dysfunction.

In a healthy cornea, endothelial cells keeps the tissue from excess fluid absorption, pumping it back into the aqueous humor. When affected by some reason, such as Fuchs' dystrophy or a trauma during cataract removal, endothelial cells suffer mortality or damage. The corneal endothelial cells normally do not undergo mitotic cell division, and cell loss results in permanent loss of function. When endothelial cell counts drop too low, the pump starts failing to function and fluid moves anterior into the stroma and epithelium. The excess fluid precipitates swelling of the cornea. As fluid accumulates between the basal epithelium cells, blister like formations form (bullae) and they undergo painful ruptures releasing their fluid content to the surface. These characteristic malformations disrupt vision and create pain sensations.

Treatment can include hyperosmotic eye drops to reduce swelling (5% sodium chloride), bandage contact lenses to reduce discomfort, glaucoma medications to reduce the flow of fluid into the cornea, and surgical procedures to replace the damaged tissue.

References

UpToDate Contents

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• 1. 成人における白内障 cataract in adults

English Journal

• Descemet stripping automated endothelial keratoplasty with a donor insertion device: clinical results and complications in 100 eyes.

• Khor WB, Han SB, Mehta JS, Tan DT.SourceSingapore National Eye Centre, Singapore; Singapore Eye Research Institute, Singapore.
• American journal of ophthalmology.Am J Ophthalmol.2013 Oct;156(4):773-779.e2. doi: 10.1016/j.ajo.2013.05.012. Epub 2013 Jul 4.
• PURPOSE: To study the clinical outcomes of Descemet stripping automated endothelial keratoplasty (DSAEK) with the EndoGlide donor insertion device.DESIGN: Retrospective interventional case series.METHODS: We included 100 eyes that underwent DSAEK for Fuchs endothelial dystrophy or pseudophakic bullo
• PMID 23831219

• Persistent Corneal Opacity After Descemet Stripping Automated Endothelial Keratoplasty Suggesting Inert Material Deposits Into the Interface.

• Chhadva P, Cabot F, Ziebarth N, Kymionis GD, Yoo SH.Source*University of Miami, Miller School of Medicine, Miami, FL; †Bascom Palmer Eye Institute, Miami, FL; ‡Biomedical Atomic Force Microscopy Laboratory, Department of Biomedical Engineering, University of Miami College of Engineering, Coral Gables, FL; and §University of Crete, Crete, Greece.
• Cornea.Cornea.2013 Sep 19. [Epub ahead of print]
• PURPOSE:: To report a case of interface deposits after Descemet stripping automated endothelial keratoplasty (DSAEK) imaged by means of an electron microscope.METHODS:: An 88-year-old man was referred with a history of corneal edema resulting from pseudophakic bullous keratopathy. A DSAEK was perfor
• PMID 24055902

• Persistence of structural changes at the anterior cornea in bullous keratopathy patients after endothelial keratoplasty.

• Morishige N, Yamada N, Morita Y, Kimura K, Sonoda KH.SourceDepartment of Ophthalmology, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan.
• PloS one.PLoS One.2013 Sep 16;8(9):e74279. doi: 10.1371/journal.pone.0074279.
• Subepithelial fibrosis (SEF) and the transdifferentiation of keratocytes into fibroblasts or myofibroblasts (Fbs/MFbs) have been detected in the cornea of individuals with bullous keratopathy. We examined the anterior cornea of bullous keratopathy patients for such changes after Descemet's stripping
• PMID 24066132

Japanese Journal

• うつむき位超音波生体顕微鏡検査を施行したレーザー虹彩切開術後に角膜内皮細胞が減少しているプラトー虹彩の2症例

• 日本眼科学会雑誌 119(2), 68-76, 2015-02
• NAID 40020356107

• 水疱性角膜症に生じた急性水腫の一例

• 眼科臨床紀要 8(3), 162-165, 2015
• NAID 40020392266

• 国内ドナーを用いた角膜内皮移植術の術後短期成績の検討

• あたらしい眼科 31(12), 1872-1875, 2014-12
• NAID 40020315443

Related Links

• Pseudophakic Bullous Keratopathy

Background Corneal edema occurs for many reasons, but it is often a sequela of intraocular surgery. Corneal edema resulting from cataract extraction is called either pseudophakic bullous keratopathy (PBK) or aphakic bullous ...

• Postoperative Corneal Edema: Background, Pathophysiology ...

Pseudophakic bullous keratopathy (PBK) and aphakic bullous keratopathy (ABK) refer to the development of irreversible corneal edema as a complication of cataract surgery. As corneal edema progresses and worsens ...

Related Pictures

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★リンクテーブル★

リンク元	「水疱性角膜症」
関連記事	「bullous」

「水疱性角膜症」

　　[★]

英

bullous keratopathy

ラ

keratitis bullosa

同

角膜水疱症

「bullous」

　　[★]

• adj.

• 水疱性の、水疱の

関

blister、bulla、bullae、chicken pox