- 延髄脊髄の、橋脊髄の
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/07/03 09:46:22」(JST)
wiki en
UpToDate Contents
全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.
- 1. 先天性ミオパシー congenital myopathies
- 2. 筋萎縮性側索硬化症およびその他の運動ニューロン疾患の診断 diagnosis of amyotrophic lateral sclerosis and other forms of motor neuron disease
English Journal
- Physical (in)activity-dependent structural plasticity in bulbospinal catecholaminergic neurons of rat rostral ventrolateral medulla.
- Mischel NA1, Llewellyn-Smith IJ, Mueller PJ.Author information 1Department of Physiology, Wayne State University School of Medicine, Detroit, Michigan, 48201.AbstractIncreased activity of the sympathetic nervous system is thought to play a role in the development and progression of cardiovascular disease. Recent work has shown that physical inactivity versus activity alters neuronal structure in brain regions associated with cardiovascular regulation. Our physiological studies suggest that neurons in the rostral ventrolateral medulla (RVLM) are more responsive to excitation in sedentary versus physically active animals. We hypothesized that enhanced functional responses in the RVLM may be due, in part, to changes in the structure of RVLM neurons that control sympathetic activity. We used retrograde tracing and immunohistochemistry for tyrosine hydroxylase (TH) to identify bulbospinal catecholaminergic (C1) neurons in sedentary and active rats after chronic voluntary wheel-running exercise. We then digitally reconstructed their cell bodies and dendrites at different rostrocaudal levels. The dendritic arbors of spinally projecting TH neurons from sedentary rats were more branched than those of physically active rats (P < 0.05). In sedentary rats, dendritic branching was greater in more rostral versus more caudal bulbospinal C1 neurons, whereas, in physically active rats, dendritic branching was consistent throughout the RVLM. In contrast, cell body size and the number of primary dendrites did not differ between active and inactive animals. We suggest that these structural changes provide an anatomical underpinning for the functional differences observed in our in vivo studies. These inactivity-related structural and functional changes may enhance the overall sensitivity of RVLM neurons to excitatory stimuli and contribute to an increased risk of cardiovascular disease in sedentary individuals.
- The Journal of comparative neurology.J Comp Neurol.2014 Feb 15;522(3):499-513. doi: 10.1002/cne.23464.
- Increased activity of the sympathetic nervous system is thought to play a role in the development and progression of cardiovascular disease. Recent work has shown that physical inactivity versus activity alters neuronal structure in brain regions associated with cardiovascular regulation. Our physio
- PMID 24114875
- Angiotensin II modulates both slow and rapid baroreflex responses of barosensitive bulbospinal neurons in the rabbit rostral ventrolateral medulla.
- Saigusa T1, Arita J.Author information 1University of Yamanashi.AbstractThis study investigated the effects of angiotensin II (Ang II) on slow and rapid baroreflex responses of barosensitive bulbospinal neurons in the rostral ventrolateral medulla (RVLM) in urethane-anesthetized rabbits to determine whether the sympathetic baroreflex modulation induced by application of Ang II into the RVLM can be explained by the total action of Ang II on individual RVLM neurons. In response to pharmacologically induced slow ramp changes in mean arterial pressure (MAP), individual RVLM neurons exhibited a unit activity-MAP relationship that was fitted by a straight line with upper and lower plateaus. Iontophoretically applied Ang II raised the upper plateau without changing the slope, and thereby increased the working range of the baroreflex response. An asymmetric sigmoid curve that was determined by averaging individual unit activity-MAP relationship lines became more symmetric with Ang II application. The characteristics of the average curves, both before and during Ang II application, were consistent with the renal sympathetic nerve activity-MAP relationship curves obtained under the same experimental conditions. Ang II also affected rapid baroreflex responses of RVLM neurons that were induced by cardiac beats, as application of Ang II predominantly raised the average unit activities in the downstroke phase of arterial pulse waves. The present study provides a possible explanation for the Ang II-induced sympathetic baroreflex modulation based on the action of Ang II on barosensitive bulbospinal RVLM neurons. Our results also suggest that Ang II changes both static and dynamic characteristics of baroreflex responses of RVLM neurons.
- American journal of physiology. Regulatory, integrative and comparative physiology.Am J Physiol Regul Integr Comp Physiol.2014 Feb 12. [Epub ahead of print]
- This study investigated the effects of angiotensin II (Ang II) on slow and rapid baroreflex responses of barosensitive bulbospinal neurons in the rostral ventrolateral medulla (RVLM) in urethane-anesthetized rabbits to determine whether the sympathetic baroreflex modulation induced by application of
- PMID 24523343
- Recent progress in the genetics of motor neuron disease.
- Finsterer J1, Burgunder JM2.Author information 1Krankenanstalt Rudolfstiftung, Postfach 20, 1180 Vienna, Austria. Electronic address: fifigs1@yahoo.de.2Department of Neurology, University of Bern, Inselspital, CH-3010 Bern, Switzerland.AbstractBACKGROUND: Genetic background and pathogenesis of motor neuron diseases (MNDs) have been increasingly elucidated over recent years.
- European journal of medical genetics.Eur J Med Genet.2014 Feb 4. pii: S1769-7212(14)00020-2. doi: 10.1016/j.ejmg.2014.01.002. [Epub ahead of print]
- BACKGROUND: Genetic background and pathogenesis of motor neuron diseases (MNDs) have been increasingly elucidated over recent years.AIMS: To give an overview about publications during the last year concerning the genetic background and phenotypic manifestations of MNDs, such as familial or sporadic
- PMID 24503148
Japanese Journal
- Activation of the Bulbospinal Serotonergic System during Experimental Tooth Movement in the Rat
- YAMASHIRO T.,FUKUNAGA T.,KABUTO H.,OGAWA N.,TAKANO-YAMAMOTO T.
- Journal of dental research 80(9), 1854-1857, 2001-09-01
- NAID 10010471429
- Fibroblast growth factor treatment produces differential effects on survival and neurite outgrowth from identified bulbospinal neurons in vitro
- PATAKY D. M.
- Exp. Neurol. 163, 357-372, 2000
- NAID 30020346204
- 女性化乳房をみとめ,常染色体優性遺伝が考えられた球脊髄性筋萎縮症の一家系
- 松浦 英治,法化図 陽一,中川 正法,有村 仁志,永松 啓爾
- 臨床神経学 39(11), 1135-1137, 1999-11-01
- NAID 10008326360
Related Links
- bul·bo·spi·nal (b l b -sp n l). adj. Relating to the medulla oblongata and spinal cord, particularly to the nerve fibers interconnecting the two. Want to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle ...
Related Pictures
★リンクテーブル★
| リンク元 | 「橋脊髄」「延髄脊髄」 |
「橋脊髄」
- 英
- bulbospinal
- 関
- 延髄脊髄
「延髄脊髄」
- 英
- bulbospinal
- 関
- 橋脊髄