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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2013/07/12 07:04:02」(JST)
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Bufuralol |
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IUPAC name
2-(tert-Butylamino)-1-(7-ethyl-1-benzofuran-2-yl)ethanol
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Identifiers |
CAS number |
54340-62-4 Y |
PubChem |
71733 |
ChemSpider |
64777 |
UNII |
891H89GFT4 |
ChEMBL |
CHEMBL296035 |
Jmol-3D images |
Image 1 |
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OC(c2oc1c(cccc1c2)CC)CNC(C)(C)C
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InChI=InChI=1S/C16H23NO2/c1-5-11-7-6-8-12-9-14(19-15(11)12)13(18)10-17-16(2,3)4/h6-9,13,17-18H,5,10H2,1-4H3
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Properties |
Molecular formula |
C16H23NO2 |
Molar mass |
261.36 g mol−1 |
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) |
Infobox references |
Bufuralol is a potent beta-adrenoceptor antagonist with partial agonist activity.[1] It is metabolized by CYP2D6.[2]
References[edit]
- ^ Pringle, TH; Francis, RJ; East, PB; Shanks, RG (1986). "Pharmacodynamic and pharmacokinetic studies on bufuralol in man". British Journal of Clinical Pharmacology 22 (5): 527–34. PMC 1401192. PMID 2878678.
- ^ Flockhart DA (2007). "Drug Interactions: Cytochrome P450 Drug Interaction Table". Indiana University School of Medicine. Retrieved on July 2011
English Journal
- Predictions of cytochrome P450-mediated drug-drug interactions using cryopreserved human hepatocytes: comparison of plasma and protein-free media incubation conditions.
- Mao J, Mohutsky MA, Harrelson JP, Wrighton SA, Hall SD.SourceDrug Disposition, Lilly Research Laboratories, Eli Lilly and Co., Lilly Corporate Center, Indianapolis, IN 46285, USA.
- Drug metabolism and disposition: the biological fate of chemicals.Drug Metab Dispos.2012 Apr;40(4):706-16. Epub 2012 Jan 6.
- Cryopreserved human hepatocytes suspended in human plasma (HHSHP) have previously provided accurate CYP3A drug-drug interaction (DDI) predictions from a single IC(50) that captures both reversible and time-dependent inhibition. The goal of this study was to compare the accuracy of DDI predictions by
- PMID 22228749
- Prediction of CYP2D6 drug interactions from in vitro data: evidence for substrate-dependent inhibition.
- VandenBrink BM, Foti RS, Rock DA, Wienkers LC, Wahlstrom JL.SourcePharmacokinetics and Drug Metabolism, Amgen, Inc., 1201 Amgen Court West, Seattle, WA 98119, USA.
- Drug metabolism and disposition: the biological fate of chemicals.Drug Metab Dispos.2012 Jan;40(1):47-53. Epub 2011 Oct 5.
- Predicting the magnitude of potential drug-drug interactions is important for underwriting patient safety in the clinical setting. Substrate-dependent inhibition of cytochrome P450 enzymes may confound extrapolation of in vitro results to the in vivo situation. However, the potential for substrate-d
- PMID 21976621
Japanese Journal
- Effects of Several Pyrethroids on Hepatic Cytochrome P450 Activities in Rats
- ABDOU Rania,KHALIL Waleed,SHAH Syed,MURASAWA Youhei,SASAKI Kazuaki,SHIMODA Minoru
- Journal of Veterinary Medical Science advpub(0), 0911280080, 2010
- … These reactions included ethoxyresorufin O-deethylation, tolbutamide hydroxylation, bufuralol 1-hydroxylation, and midazolam 4-hydroxylation, for CYP1A, 2C, 2D, and 3A activities, respectively. …
- NAID 130000149939
- HPLC separation technique for analysis of bufuralol enantiomers in plasma and pharmaceutical formulations using a vancomycin chiral stationary phase and UV detection
- HEFNAWY Mohamed M.,SULTAN Maha A.,AL-SHEHRI Mona M.
- Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 856(1), 328-336, 2007-09-01
- NAID 10025808169
Related Links
- Buy Bufuralol, Hydrochloride (CAS 59652-29-8), a β-Adrenergic blocker, from Santa Cruz. Molecular Formula C16H23NO2 HCl, Molecular Weight 297.82 ... Bufuralol, Hydrochloride, a benzofuran derivative, has been shown to act as ...
- ... CYP2D6.2, and CYP2D6.17 activities toward model CYP2D6 substrates dextromethorphan, bufuralol, and debrisoquine. Drug metabolism and disposition: the biological fate of chemicals. 2002. Marcucci Kenda A, et al. VA ...
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