bufuralol

Bufuralol
	IUPAC name 2-(tert-Butylamino)-1-(7-ethyl-1-benzofuran-2-yl)ethanol
Identifiers
CAS number	54340-62-4
PubChem	71733
ChemSpider	64777
UNII	891H89GFT4
ChEMBL	CHEMBL296035
Jmol-3D images	Image 1
	SMILES OC(c2oc1c(cccc1c2)CC)CNC(C)(C)C ;
	InChI InChI=InChI=1S/C16H23NO2/c1-5-11-7-6-8-12-9-14(19-15(11)12)13(18)10-17-16(2,3)4/h6-9,13,17-18H,5,10H2,1-4H3 ;
Properties
Molecular formula	C16H23NO2
Molar mass	261.36 g mol−1
	Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
	Infobox references

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/07/12 07:04:02」(JST)

Predictions of cytochrome P450-mediated drug-drug interactions using cryopreserved human hepatocytes: comparison of plasma and protein-free media incubation conditions.

Mao J, Mohutsky MA, Harrelson JP, Wrighton SA, Hall SD.SourceDrug Disposition, Lilly Research Laboratories, Eli Lilly and Co., Lilly Corporate Center, Indianapolis, IN 46285, USA.
Drug metabolism and disposition: the biological fate of chemicals.Drug Metab Dispos.2012 Apr;40(4):706-16. Epub 2012 Jan 6.
Cryopreserved human hepatocytes suspended in human plasma (HHSHP) have previously provided accurate CYP3A drug-drug interaction (DDI) predictions from a single IC(50) that captures both reversible and time-dependent inhibition. The goal of this study was to compare the accuracy of DDI predictions by
PMID 22228749

Prediction of CYP2D6 drug interactions from in vitro data: evidence for substrate-dependent inhibition.

VandenBrink BM, Foti RS, Rock DA, Wienkers LC, Wahlstrom JL.SourcePharmacokinetics and Drug Metabolism, Amgen, Inc., 1201 Amgen Court West, Seattle, WA 98119, USA.
Drug metabolism and disposition: the biological fate of chemicals.Drug Metab Dispos.2012 Jan;40(1):47-53. Epub 2011 Oct 5.
Predicting the magnitude of potential drug-drug interactions is important for underwriting patient safety in the clinical setting. Substrate-dependent inhibition of cytochrome P450 enzymes may confound extrapolation of in vitro results to the in vivo situation. However, the potential for substrate-d
PMID 21976621

ABDOU Rania,KHALIL Waleed,SHAH Syed,MURASAWA Youhei,SASAKI Kazuaki,SHIMODA Minoru
Journal of Veterinary Medical Science advpub(0), 0911280080, 2010
… These reactions included ethoxyresorufin O-deethylation, tolbutamide hydroxylation, bufuralol 1-hydroxylation, and midazolam 4-hydroxylation, for CYP1A, 2C, 2D, and 3A activities, respectively. …
NAID 130000149939

HPLC separation technique for analysis of bufuralol enantiomers in plasma and pharmaceutical formulations using a vancomycin chiral stationary phase and UV detection

HEFNAWY Mohamed M.,SULTAN Maha A.,AL-SHEHRI Mona M.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 856(1), 328-336, 2007-09-01
NAID 10025808169

Bufuralol

IUPAC name 2-(tert-Butylamino)-1-(7-ethyl-1-benzofuran-2-yl)ethanol
Identifiers
CAS number	54340-62-4^Y
PubChem	71733
ChemSpider	64777
UNII	891H89GFT4
ChEMBL	CHEMBL296035
Jmol-3D images	Image 1
SMILES OC(c2oc1c(cccc1c2)CC)CNC(C)(C)C
InChI InChI=InChI=1S/C16H23NO2/c1-5-11-7-6-8-12-9-14(19-15(11)12)13(18)10-17-16(2,3)4/h6-9,13,17-18H,5,10H2,1-4H3
Properties
Molecular formula	C₁₆H₂₃NO₂
Molar mass	261.36 g mol⁻¹
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references