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English Journal

Mono-allelic VSG expression by RNA polymerase I in Trypanosoma brucei: Expression site control from both ends?

Günzl A1, Kirkham JK2, Nguyen TN2, Badjatia N2, Park SH2.
Gene.Gene.2015 Feb 1;556(1):68-73. doi: 10.1016/j.gene.2014.09.047. Epub 2014 Sep 26.
Trypanosoma brucei is a vector borne, lethal protistan parasite of humans and livestock in sub-Saharan Africa. Antigenic variation of its cell surface coat enables the parasite to evade adaptive immune responses and to live freely in the blood of its mammalian hosts. The coat consists of ten million
PMID 25261847

Nanobody conjugated PLGA nanoparticles for active targeting of African Trypanosomiasis.

Arias JL1, Unciti-Broceta JD2, Maceira J2, Del Castillo T2, Hernández-Quero J3, Magez S4, Soriano M5, García-Salcedo JA6.
Journal of controlled release : official journal of the Controlled Release Society.J Control Release.2015 Jan 10;197C:190-198. doi: 10.1016/j.jconrel.2014.11.002. Epub 2014 Nov 10.
Targeted delivery of therapeutics is an alternative approach for the selective treatment of infectious diseases. The surface of African trypanosomes, the causative agents of African trypanosomiasis, is covered by a surface coat consisting of a single variant surface glycoprotein, termed VSG. This co
PMID 25445702

Construction of Trypanosoma brucei Illumina RNA-Seq Libraries Enriched for Transcript Ends.

Kolev NG1, Ullu E, Tschudi C.
Methods in molecular biology (Clifton, N.J.).Methods Mol Biol.2015;1201:165-75. doi: 10.1007/978-1-4939-1438-8_9.
High-throughput RNA sequencing (RNA-Seq) has quickly occupied center stage in the repertoire of available tools for transcriptomics. Among many advantages, the single-nucleotide resolution of this powerful approach allows mapping on a genome-wide scale of splice junctions and polyadenylation sites,
PMID 25388113

Development of multiplex serological assay for the detection of human African trypanosomiasis

Identification and characterization of a cell division-regulating kinase AKB1 (associated kinase of Trypanosoma brucei 14-3-3) through proteomics study of the Tb14-3-3 binding proteins

Application of crude and recombinant ELISAs and immunochromatographic test for serodiagnosis of animal trypanosomosis in the Umkhanyakude district of KwaZulu-Natal province, South Africa