bronchoconstrictive

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1. 小児の喘鳴へのアプローチ approach to wheezing in children
2. 成人における喘息以外の喘鳴をきたす疾患の評価 evaluation of wheezing illnesses other than asthma in adults
3. ウイルス誘発性の喘鳴および喘息：概要 virus induced wheezing and asthma an overview
4. 小児における喘息以外の喘鳴疾患 wheezing illnesses other than asthma in children
5. 幼児における再発するウイルス誘発性喘鳴の治療 treatment of recurrent virus induced wheezing in young children

Selective targeting of the α5-subunit of GABAA receptors relaxes airway smooth muscle and inhibits cellular calcium handling.

Gallos G1, Yocum GT2, Siviski ME2, Yim PD2, Fu XW2, Poe MM3, Cook JM3, Harrison N2, Perez-Zoghbi J4, Emala CW Sr2.
American journal of physiology. Lung cellular and molecular physiology.Am J Physiol Lung Cell Mol Physiol.2015 May 1;308(9):L931-42. doi: 10.1152/ajplung.00107.2014. Epub 2015 Feb 6.
The clinical need for novel bronchodilators for the treatment of bronchoconstrictive diseases remains a major medical issue. Modulation of airway smooth muscle (ASM) chloride via GABAA receptor activation to achieve relaxation of precontracted ASM represents a potentially beneficial therapeutic opti
PMID 25659897

In vivo evaluation of the antitussive, expectorant and bronchodilating effects of extract and fractions from aerial parts of Peganum harmala linn.

Liu W1, Cheng X2, Wang Y2, Li S1, Zheng T1, Gao Y1, Wang G1, Qi S1, Wang J1, Ni J1, Wang Z2, Wang C3.
Journal of ethnopharmacology.J Ethnopharmacol.2015 Mar 13;162:79-86. doi: 10.1016/j.jep.2014.12.046. Epub 2014 Dec 31.
ETHNOPHARMACOLOGICAL RELEVANCE: Aerial parts of Peganum harmala Linn (APP) is used as traditional medical herb in Uighur medicine in China, and it is traditionally used for treatment of cough and asthma.The aim of the present study is to evaluate the antitussive, expectorant and bronchodilating effe
PMID 25557031

Chloride channel blockade relaxes airway smooth muscle and potentiates relaxation by β-agonists.

Danielsson J1, Yim P2, Rinderspacher A3, Fu XW2, Zhang Y2, Landry DW3, Emala CW2.
American journal of physiology. Lung cellular and molecular physiology.Am J Physiol Lung Cell Mol Physiol.2014 Aug 1;307(3):L273-82. doi: 10.1152/ajplung.00351.2013. Epub 2014 May 30.
Severe bronchospasm refractory to β-agonists continues to cause significant morbidity and mortality in asthmatic patients. We questioned whether chloride channels/transporters are novel targets for the relaxation of airway smooth muscle (ASM). We have screened a library of compounds, derivatives of
PMID 24879056

Chloride channel blockers promote relaxation of TEA-induced contraction in airway smooth muscle

, , , , , , ,
Journal of Smooth Muscle Research 49(0), 112-124, 2013
… Targeting of chloride channels may be a novel approach to relax hypercontractile airway smooth muscle in bronchoconstrictive disorders. …
NAID 130003391238

小山晴美,徳山研一,森川昭廣
日本小児アレルギー学会誌 = The Japanese journal of pediatric allergy and clinical immunology 22(2), 239-244, 2008-06-01
NAID 10026940254

小山晴美,徳山研一,森川昭廣
日本小児アレルギー学会誌 22(2), 239-244, 2008
気道粘液は生体防御システムに関与するが，喘息においては気道粘液産生過多や粘液産生細胞過形成などが惹起され疾患の増悪に働く．我々は喘息モデルマウスを用いて抗原誘発による２相性気道反応時の気道内粘液量を半定量的に検討したところ，遅発型気道反応時の気道閉塞において粘液過分泌が重要な役割を果たすこと，また粘液過分泌制御に対して DSCG が抑制効果を有することを示した．気道分泌制御を目的とした研究は，喘息 …
NAID 130004504161