bromperidol

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/08/09 13:07:47」(JST)

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Bromperidol

Clinical data
Trade names	Bromidol, Bromodol
AHFS/Drugs.com	International Drug Names
Routes of administration	Oral
ATC code	N05AD06 (WHO)
Identifiers
IUPAC name 4-[4-(4-bromophenyl)-4-hydroxypiperidin-1-yl]-1-(4-fluorophenyl)butan-1-one
CAS Number	10457-90-6 N
PubChem CID	2448
ChemSpider	2354 Y
UNII	LYH6F7I22E
KEGG	D01101 Y
ChEMBL	CHEMBL28218 Y
ECHA InfoCard	100.030.845
Chemical and physical data
Formula	C21H23BrFNO2
Molar mass	420.315 g/mol
3D model (JSmol)	Interactive image
SMILES Fc1ccc(cc1)C(=O)CCCN3CCC(O)(c2ccc(Br)cc2)CC3
InChI InChI=1S/C21H23BrFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2 Y Key:RKLNONIVDFXQRX-UHFFFAOYSA-N Y
NY (what is this?)  (verify)

Bromperidol (marketed as Bromidol, Bromodol) is a butyrophenone derivative. It is a potent and long-acting neuroleptic, used as an antipsychotic in the treatment of schizophrenia. It was discovered at Janssen Pharmaceutica in 1966.

References

• Poldinger W, Bures E, Haage H, Clinical study with bromperidol, a new butyrophenone derivative, Int Pharmacopsychiatry. 1977;12(1):20-4.
• Dubinsky B, McGuire JL, Niemegeers CJ, Janssen PA, Weintraub HS, McKenzie BE, Bromperidol, a new butyrophenone neuroleptic: a review, Psychopharmacology (Berl). 1982;78(1):1-7.

English Journal

• The use of dried blood spots for quantification of 15 antipsychotics and 7 metabolites with ultra-high performance liquid chromatography - tandem mass spectrometry.

• Patteet L1,2, Maudens KE1, Stove CP3, Lambert WE3, Morrens M4, Sabbe B4, Neels H1,2.
• Drug testing and analysis.Drug Test Anal.2015 Jun;7(6):502-11. doi: 10.1002/dta.1698. Epub 2014 Jul 31.
• Therapeutic drug monitoring of antipsychotics is important in optimizing individual therapy. In psychiatric populations, classical venous blood sampling is experienced as frightening. Interest in alternative techniques, like dried blood spots (DBS), has consequently increased. A fast and easy to per
• PMID 25132670

• Haloperidol versus first-generation antipsychotics for the treatment of schizophrenia and other psychotic disorders.

• Dold M1, Samara MT, Li C, Tardy M, Leucht S.
• The Cochrane database of systematic reviews.Cochrane Database Syst Rev.2015 Jan 16;1:CD009831. doi: 10.1002/14651858.CD009831.pub2.
• BACKGROUND: Haloperidol is worldwide one of the most frequently used antipsychotic drugs with a very high market share. Previous narrative, unsystematic reviews found no differences in terms of efficacy between the various first-generation ("conventional", "typical") antipsychotic agents. This estab
• PMID 25592299

• High throughput identification and quantification of 16 antipsychotics and 8 major metabolites in serum using ultra-high performance liquid chromatography-tandem mass spectrometry.

• Patteet L1, Maudens KE2, Sabbe B3, Morrens M4, De Doncker M5, Neels H6.
• Clinica chimica acta; international journal of clinical chemistry.Clin Chim Acta.2014 Feb 15;429:51-8. doi: 10.1016/j.cca.2013.11.024. Epub 2013 Nov 28.
• BACKGROUND: Therapeutic drug monitoring of antipsychotics is important for optimizing therapy, explaining adverse effects, non-response or poor compliance. We developed a UHPLC-MS/MS method for quantification of 16 commonly used and recently marketed antipsychotics and 8 metabolites in serum.METHODS
• PMID 24291056

Japanese Journal

• 抗精神病薬長期服用患者の硬膜外併用全身麻酔中に低血圧,心停止を生じた1症例

• 麻酔 61(10), 1121-1124, 2012-10
• NAID 40019448460

• 薬物分析検査 精神神経用薬 ブチロフェノン系抗精神病薬 (広範囲 血液・尿化学検査 免疫学的検査(第7版・2)その数値をどう読むか) -- (生化学的検査(2))

• 日本臨床 68(-), 403-405, 2010-01
• NAID 40016932863

• Improvement in antipsychotic-induced hyperprolactinemia with the addition of aripiprazole in schizophrenic patients

• Clinical Neuropsychopharmacology and Therapeutics 1, 1-5, 2010
• NAID 130000405620

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