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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/08/27 23:05:48」(JST)

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Bromazine (trade names Ambrodyl, Ambrodil and others), also known as bromodiphenhydramine, is an antihistamine and anticholinergic.^[1] It is a halogenated form of diphenhydramine and in many respects is somewhat stronger than the parent compound. The other three halogenated diphenhydramine derivatives are used in research and chlorodiphenhydramine is also marketed with iododiphenhydramine being a much less common pharmaceutical.

References

^ MacLaren, W. R.; Bruff, W. C.; Eisenberg, B. C.; Weiner, H.; Martin, W. H. (1955). "A clinical comparison of carbinoxamine maleate, tripelennamine hydrochloride, and bromodiphenhydramine hydrochloride in treating allergic symptoms". Annals of allergy 13 (3): 307–312. PMID 14377226. edit

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English Journal

Synthesis and anti-inflammatory effects of new piperazine and ethanolamine derivatives of H(1)-antihistaminic drugs.

Ahmadi A1, Khalili M, Nafarie A, Yazdani A, Nahri-Niknafs B.
Mini reviews in medicinal chemistry.Mini Rev Med Chem.2012 Oct;12(12):1282-92.
In addition to their antihistamine effects, H1-receptor antagonists possess pharmacological properties that are not uniformly distributed among this class of drugs, such as anti-inflammatory, anti-allergic and antiplatelet activities. In this paper, Cyclizine (1-benzhydryl-4-methyl-piperazine, I), b
PMID 22876948

Bisubstrates: substances that interact with renal contraluminal organic anion and organic cation transport systems. I. Amines, piperidines, piperazines, azepines, pyridines, quinolines, imidazoles, thiazoles, guanidines and hydrazines.

Ullrich KJ1, Rumrich G, David C, Fritzsch G.
Pflügers Archiv : European journal of physiology.Pflugers Arch.1993 Nov;425(3-4):280-99.
In order to evaluate whether N-containing substrates interact with the organic "anion" (p-aminohippurate, PAH) or only with the organic "cation" (N1-methylnicotinamide, NMeN) transport system or with both, the stop-flow peritubular capillary microperfusion method was applied in the rat kidney in sit
PMID 8309790

Pedagogical patronizing of the pharmacodynamic promises of illicit drugs.

Belcastro PA1.
Journal of drug education.J Drug Educ.1992;22(1):9-13.
A review of popular drug education textbooks and curricula indicated most juxtapose the physiologic effects of licitly manufactured drugs under headings representing illicitly prepared drugs. This misrepresentation ignores the literature, which is undivided, in reporting that illicit drugs contain a
PMID 1593391

「ブロマジン」

Bromazine
Systematic (IUPAC) name
	2-[(4-bromophenyl)-phenylmethoxy]-N,N-dimethylethanamine
Clinical data
MedlinePlus	a682065
Legal status	?
Routes	Oral
Pharmacokinetic data
Bioavailability	High
Protein binding	96%
Metabolism	Mostly hepatic (CYP-mediated), also renal
Half-life	1 to 4 hours
Identifiers
CAS number	1808-12-4 1808-12-4
ATC code	R06AA01
PubChem	CID 2444
DrugBank	DB01237
ChemSpider	2350
UNII	202J683U97
ChEBI	CHEBI:59177
ChEMBL	CHEMBL1201245
Chemical data
Formula	C17H20BrNO
Mol. mass	334.251 g/mol
	SMILES Brc1ccc(cc1)C(OCCN(C)C)c2ccccc2;
	InChI InChI=1S/C17H20BrNO/c1-19(2)12-13-20-17(14-6-4-3-5-7-14)15-8-10-16(18)11-9-15/h3-11,17H,12-13H2,1-2H3 ; Key:NUNIWXHYABYXKF-UHFFFAOYSA-N ;
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