brain tumor

出典: meddic

脳腫瘍

Brain tumors
specific types

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2013/01/17 01:03:17」(JST)

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英文文献

  • Interaction of allergy history and antibodies to specific varicella-zoster virus proteins on glioma risk.
  • Lee ST1, Bracci P, Zhou M, Rice T, Wiencke J, Wrensch M, Wiemels J.Author information 1Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA; Department of Laboratory Medicine & Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.AbstractGlioma is the most common cancer of the central nervous system but with few confirmed risk factors. It has been inversely associated with chicken pox, shingles and seroreactivity to varicella virus (VZV), as well as to allergies and allergy-associated IgE. The role of antibody reactivity against individual VZV antigens has not been assessed. Ten VZV-related proteins, selected for high immunogenicity or known function, were synthesized and used as targets for antibody measurements in the sera of 143 glioma cases and 131 healthy controls selected from the San Francisco Bay Area Adult Glioma Study. Glioma cases exhibited significantly reduced seroreactivity compared to controls for six antigens, including proteins IE63 [odds ratio (OR) = 0.26, 95% confidence interval (CI): 0.12-0.58, comparing lowest quartile to highest) and the VZV-unique protein ORF2p (OR = 0.44, 95% CI: 0.21-0.96, lowest quartile to highest). When stratifying the study population into those with low and high self-reported allergy history, VZV protein seroreactivity was only associated inversely with glioma among individuals self-reporting more than two allergies. The data provide insight into both allergy and VZV effects on glioma: strong anti-VZV reactions in highly allergic individuals are associated with reduced occurrence of glioma. This result suggests a role for specificity in the anti-VZV immunity in brain tumor suppression for both individual VZV antigens and in the fine-tuning of the immune response by allergy. Anti-VZV reactions may also be a biomarker of effective CNS immunosurveillance owing to the tropism of the virus.
  • International journal of cancer. Journal international du cancer.Int J Cancer.2014 May 1;134(9):2199-210. doi: 10.1002/ijc.28535. Epub 2013 Oct 31.
  • Glioma is the most common cancer of the central nervous system but with few confirmed risk factors. It has been inversely associated with chicken pox, shingles and seroreactivity to varicella virus (VZV), as well as to allergies and allergy-associated IgE. The role of antibody reactivity against ind
  • PMID 24127236
  • Can in-vitro chemoresponse assays help find new treatment regimens for malignant gliomas?
  • Linz U1, Ulus B, Neuloh G, Clusmann H, Oertel M, Nolte K, Weis J, Heussen N, Gilsbach JM.Author information 1aResearch Center Jülich (FZJ), Institute of Complex Systems, Jülich bDepartment of Neurosurgery cDepartment of Neuropathology dDepartment of Medical Statistics, RWTH Aachen University, Aachen, Germany.AbstractVarious in-vitro chemosensitivity and resistance assays (CSRAs) have been demonstrated to be helpful decision aids for non-neurological tumors. Here, we evaluated the performance characteristics of two CSRAs for glioblastoma (GB) cells. The chemoresponse of fresh GB cells from 30 patients was studied in vitro using the ATP tumor chemoresponse assay and the chemotherapy resistance assay (CTR-Test). Both assay platforms provided comparable results. Of seven different chemotherapeutic drugs and drug combinations tested in vitro, treosulfan plus cytarabine (TARA) was the most effective, followed by nimustine (ACNU) plus teniposide (VM26) and temozolomide (TMZ). Whereas ACNU/VM26 and TMZ have proven their clinical value for malignant gliomas in large randomized studies, TARA has not been successful in newly diagnosed gliomas. This seeming discrepancy between in vitro and clinical result might be explained by the pharmacological behavior of treosulfan. Our results show reasonable agreement between two cell-based CSRAs. They appear to confirm the clinical effectiveness of drugs used in GB treatment as long as pharmacological preconditions such as overcoming the blood-brain barrier are properly considered.
  • Anti-cancer drugs.Anticancer Drugs.2014 Apr;25(4):375-84. doi: 10.1097/CAD.0000000000000062.
  • Various in-vitro chemosensitivity and resistance assays (CSRAs) have been demonstrated to be helpful decision aids for non-neurological tumors. Here, we evaluated the performance characteristics of two CSRAs for glioblastoma (GB) cells. The chemoresponse of fresh GB cells from 30 patients was studie
  • PMID 24423983
  • Modulation of Mcl-1 sensitizes glioblastoma to TRAIL-induced apoptosis.
  • Murphy AC1, Weyhenmeyer B, Noonan J, Kilbride SM, Schimansky S, Loh KP, Kögel D, Letai AG, Prehn JH, Murphy BM.Author information 1Centre for Systems Medicine, Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, York House, St. Stephen's Green, Dublin, 2, Ireland.AbstractGlioblastoma (GBM) is the most aggressive form of primary brain tumour, with dismal patient outcome. Treatment failure is associated with intrinsic or acquired apoptosis resistance and the presence of a highly tumourigenic subpopulation of cancer cells called GBM stem cells. Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) has emerged as a promising novel therapy for some treatment-resistant tumours but unfortunately GBM can be completely resistant to TRAIL monotherapy. In this study, we identified Mcl-1, an anti-apoptotic Bcl-2 family member, as a critical player involved in determining the sensitivity of GBM to TRAIL-induced apoptosis. Effective targeting of Mcl-1 in TRAIL resistant GBM cells, either by gene silencing technology or by treatment with R-roscovitine, a cyclin-dependent kinase inhibitor that targets Mcl-1, was demonstrated to augment sensitivity to TRAIL, both within GBM cells grown as monolayers and in a 3D tumour model. Finally, we highlight that two separate pathways are activated during the apoptotic death of GBM cells treated with a combination of TRAIL and R-roscovitine, one which leads to caspase-8 and caspase-3 activation and a second pathway, involving a Mcl-1:Noxa axis. In conclusion, our study demonstrates that R-roscovitine in combination with TRAIL presents a promising novel strategy to trigger cell death pathways in glioblastoma.
  • Apoptosis : an international journal on programmed cell death.Apoptosis.2014 Apr;19(4):629-42. doi: 10.1007/s10495-013-0935-2.
  • Glioblastoma (GBM) is the most aggressive form of primary brain tumour, with dismal patient outcome. Treatment failure is associated with intrinsic or acquired apoptosis resistance and the presence of a highly tumourigenic subpopulation of cancer cells called GBM stem cells. Tumour necrosis factor-r
  • PMID 24213561

和文文献

  • がんの最新治療 各論(15)転移性脳腫瘍に対するガンマナイフ治療
  • 田村 徳子,林 基弘
  • 東京女子医科大学雑誌 83(6), 384-390, 2013-12-25
  • ガンマナイフ治療は脳腫瘍、脳動静脈奇形、機能的疾患に対して「頭を切り開かない治療」として脳神経外科領域にて広く行われている。,現在、がん治療において、化学療法の進歩や分子標的薬の台頭により、治療成績が向上してきている。その一方で脳転移症例において、全身状態が比較的良好に保たれていることも多く、脳転移巣のコントロールが重要になってきている。脳転移治療の目的は、脳転移による患者QOLの低下を防ぎ、でき …
  • NAID 110009659602
  • 症例報告 術前腫瘍塞栓術と腫瘍摘出術により視野障害が段階的に改善した胞巣状軟部肉腫の後頭葉内脳転移の1例
  • 肺転移に対するスニチニブの奏功期間中に脳転移が出現した腎細胞癌の1例
  • 森澤 洋介,百瀬 均,豊島 優多,高田 聡,藤本 健,大山 信雄
  • 泌尿器科紀要 59(12), 791-793, 2013-12
  • Brain magnetic resonance imaging (MRI) revealed a 3 cm tumor in his frontal lobe of cerebrum. … He underwent surgical resection of the tumor and pathological diagnosis was metastatic renal cell carcinoma. …
  • NAID 120005359207

関連リンク

National Brain Tumor Society is fiercely committed to finding better treatments, and ultimately a cure, for people living with a brain tumor today and anyone who will be diagnosed tomorrow. This means effecting change in the system ...
脳腫瘍病理をキーワードに診断、治療、予後に関する研究交流の場であり、脳腫瘍に興味を持つ様々な分野の研究者で構成されている。機関誌“Brain Tumor Pathology”は、脳腫瘍の病理診断、治療法、各種統計、最新の病理診断法や ...
Brain tumors are currently the leading cause of death among children with cancer. Only 60% of these children will survive into adulthood. That is not an acceptable statistic. 日本語 現在、脳腫瘍は癌の子供の主な死亡原因です。 これら ...

関連画像

brain-tumor.jpgbrain tumor Top 10 Dangerous affects of Description MRI brain tumor.jpgBrain Tumor Diagnosis – All You Need To Description CT brain tumor.jpgbrain tumor is a mass or growth of


★リンクテーブル★
リンク元脳腫瘍」「brain neoplasm」「intracranial neoplasm」「brain cancer」「cancer of the brain
拡張検索primary brain tumor」「malignant primary brain tumor」「midbrain tumor
関連記事brain」「tumor」「bra

脳腫瘍」

  [★]

brain tumor, cerebral tumor
脳新生物 brain neoplasm
頭蓋内腫瘍

概念

分類

疫学

腫瘍別発生頻度

腫瘍別発生頻度 小児 成人
神経膠腫 33% 星状細胞腫 髄膜腫
髄膜腫 22% 髄芽腫 膠芽腫
下垂体腺腫 15% 頭蓋咽頭腫 下垂体腺腫
神経鞘腫 9% 胚細胞腫 神経鞘腫
頭蓋咽頭腫 5% 上衣腫 転移性脳腫瘍

YN.J.188

部位 種類 小児 成人
頭蓋骨 頭蓋骨腫瘍
大脳半球 神経膠腫  
髄膜腫  
松果体 胚細胞腫  
小脳半球 星細胞腫  
血管芽腫  
小脳虫部 髄芽腫  
第四脳室 上衣腫  
鞍上部・
視交叉部・
下垂体部
頭蓋咽頭腫  
視神経膠腫  
胚細胞腫  
下垂体腺腫  
髄膜腫  
小脳橋角部 聴神経鞘腫  
脳幹部 神経膠腫

小児の脳腫瘍

SCN.173
  • 腫瘍:星細胞腫、髄芽腫、頭蓋咽頭腫、胚細胞腫、上衣腫の順に多い。
  • 部位:1歳まではテント上、2-7歳まではテント下、8-15歳まではテント上に多い。

放射線感受性

SCN.173
  • (高い)髄芽腫、胚細胞腫 > (低い)神経膠腫

転移性脳腫瘍

  • 肺癌(約半数)、乳癌、消化器癌、腎癌
  • 頻度:肺癌>乳癌>胃・腸癌 (SCN.173)

石灰化が見られる脳腫瘍

  • 乏突起膠腫:CT上、低吸収領域の中に石灰化がみられる。(SCN.173)
  • 上衣腫:CT:(単純CT)等~低吸収、(造影CT)中~強度の増強。小嚢胞や壊死、石灰化を認める
  • 髄膜腫:腫瘍の一部石灰化が少なからず見られる
  • 頭蓋咽頭腫:小児において石灰沈着が高頻度にみられる。

嚢胞性腫瘍

参考

  • 1. がんサポートセンター 脳腫瘍
[display]http://www.gsic.jp/cancer/cc_19/hc/02.html
  • 1-1. がんサポートセンター 脳腫瘍 フローチャート
[display]http://www.gsic.jp/cancer/cc_19/hc/cc_19_021.html
  • 2. 脳腫瘍 治療法ガイドライン [総論]
[display]http://www.ebm.jp/disease/brain/07noshuyo1/guide.html
  • 3. 資料
[display]http://ganjoho.ncc.go.jp/public/cancer/data/brain_adult.html
  • 4. 資料
[display]http://ganjoho.ncc.go.jp/public/cancer/data/brain_child.html
  • 5. 小児脳腫瘍
[display]http://www.geocities.jp/ululu_o_ululu/report-11.html

国試



brain neoplasm」

  [★]

脳腫瘍脳新生物

brain cancerbrain tumorbrain tumourcancer of the brainintracranial neoplasmmalignant brain neoplasmmalignant primary brain tumorprimary brain neoplasmprimary brain tumorprimary malignant brain tumorrecurrent brain tumor


intracranial neoplasm」

  [★]

頭蓋内腫瘍頭蓋内新生物

brain cancerbrain neoplasmbrain tumorcancer of the brainmalignant brain neoplasmmalignant primary brain tumorprimary brain neoplasmprimary brain tumorprimary malignant brain tumorrecurrent brain tumor


brain cancer」

  [★]

脳癌脳がん

brain neoplasmbrain tumorcancer of the brainintracranial neoplasmmalignant brain neoplasmmalignant primary brain tumorprimary brain neoplasmprimary brain tumorprimary malignant brain tumorrecurrent brain tumor


cancer of the brain」

  [★]

脳癌脳がん

brain cancerbrain neoplasmbrain tumorintracranial neoplasmmalignant brain neoplasmmalignant primary brain tumorprimary brain neoplasmprimary brain tumorprimary malignant brain tumorrecurrent brain tumor


primary brain tumor」

  [★]

原発性脳腫瘍

brain cancerbrain neoplasmbrain tumorcancer of the brainintracranial neoplasmmalignant brain neoplasmmalignant primary brain tumorprimary brain neoplasmprimary malignant brain tumorrecurrent brain tumor


malignant primary brain tumor」

  [★]

悪性原発性脳腫瘍

brain cancerbrain neoplasmbrain tumorcancer of the brainintracranial neoplasmmalignant brain neoplasmprimary brain neoplasmprimary brain tumorprimary malignant brain tumorrecurrent brain tumor


midbrain tumor」

  [★]

中脳腫瘍

brain stem neoplasmmedullary tumor


brain」

  [★]


WordNet   license wordnet

「kill by smashing someone''s skull」

WordNet   license wordnet

「mental ability; "he''s got plenty of brains but no common sense"」
brainpower, learning ability, mental capacity, mentality, wit

WordNet   license wordnet

「that part of the central nervous system that includes all the higher nervous centers; enclosed within the skull; continuous with the spinal cord」
encephalon

WordNet   license wordnet

「the brain of certain animals used as meat」

PrepTutorEJDIC   license prepejdic

「『脳』,脳髄 / 《しばしば複数形で》『頭脳』,『知力』 / 《話》秀才,知的指導者 / …‘の'頭を打ち砕く」

WordNet   license wordnet

「hit on the head」


tumor」

  [★]

  • n.


WordNet   license wordnet

「an abnormal new mass of tissue that serves no purpose」
tumour, neoplasm


bra」

  [★]

PrepTutorEJDIC   license prepejdic

「=brassiere, brassiere」




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