brain:blood partition coefficient

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英文文献

  • Isomer-selective distribution of 3-n-butylphthalide (NBP) hydroxylated metabolites, 3-hydroxy-NBP and 10-hydroxy-NBP, across the rat blood-brain barrier.
  • Diao XX1, Zhong K1, Li XL1, Zhong DF1, Chen XY1.
  • Acta pharmacologica Sinica.Acta Pharmacol Sin.2015 Dec;36(12):1520-7. doi: 10.1038/aps.2015.64. Epub 2015 Nov 16.
  • AIM: To investigate the mechanisms underlying the isomer-selective distribution of 3-n-butylphthalide (NBP) hydroxylated metabolites, 3-hydroxy-NBP (3-OH-NBP) and 10-hydroxy-NBP (10-OH-NBP), across the blood brain barrier (BBB).METHODS: After oral administration of NBP (20 mg/kg) to rats, the pharma
  • PMID 26567730
  • Preparation and biodistribution of 1-((2-methoxyphenyl) piperazine)ferrocenecarboxamide labeled with technetium-99m as a potential brain receptor imaging agent.
  • Saied NM1, Mejri N2, El Aissi R3, Benoist E4, Saidi M2.
  • European journal of medicinal chemistry.Eur J Med Chem.2015 Jun 5;97:280-8. doi: 10.1016/j.ejmech.2015.05.014. Epub 2015 May 9.
  • The goal of this study is to develop a novel brain receptor imaging agent. This study reports the synthesis, characterization and the biological evaluation of 1-((2-methoxyphenyl) piperazine)ferrocenecarboxamide labeled with technetium-99 m ((99m)Tc-MP). The (99m)Tc-MP was obtained quickly (radiola
  • PMID 25993108
  • Quantification and significance of diffuse myocardial fibrosis and diastolic dysfunction in childhood hypertrophic cardiomyopathy.
  • Hussain T1, Dragulescu A, Benson L, Yoo SJ, Meng H, Windram J, Wong D, Greiser A, Friedberg M, Mertens L, Seed M, Redington A, Grosse-Wortmann L.
  • Pediatric cardiology.Pediatr Cardiol.2015 Jun;36(5):970-8. doi: 10.1007/s00246-015-1107-7. Epub 2015 Jan 21.
  • The purpose of this study was to evaluate the presence of diffuse myocardial fibrosis in children and adolescents with hypertrophic cardiomyopathy (HCM) and to assess associations with echocardiographic and clinical parameters of disease. While a common end point in adults with HCM, it is unclear wh
  • PMID 25605038

和文文献

  • Regional partition coefficient of water in patients with cerebrovascular disease and its effect on rCBF assessment
  • Hirata Kenji,Hattori Naoya,Katoh Chietsugu,Shiga Tohru,Kuroda Satoshi,Kubo Naoki,Usui Reiko,Kuge Yuji,Tamaki Nagara
  • Nuclear Medicine Communications 32(1), 63-70, 2011-01
  • … Objective: Cerebral blood flow (CBF) estimation with C15O2 PET usually assumes a single tissue compartment model and a fixed brain-blood partition coefficient of water. … However, the partition coefficient may change in pathological conditions. …
  • NAID 120003660577

関連リンク

... imaging (MRI) provides repetitive, noninvasive CBF quantification. Many MRI techniques require the knowledge of the brain–blood partition coefficient (BBPC) for water. Adopting an MRI protocol described by Roberts et al (1996) ...
Summary of "Determination of the brain-blood partition coefficient for water in mice using MRI." Cerebral blood flow (CBF) quantification is a valuable tool in stroke research. Mice are of special interest because of the potential of ...

関連画像

Inhaled anesthetic with the highest and Does high or low blood solubility of an Neuroanatomy Lecture #21: Transport w/in P6 Solubility & Transport flashcards the above table, BBB denotes blood-brain brain uptake index and oil/water partition


★リンクテーブル★
関連記事partition」「blood」「brain」「coefficient」「blooded

partition」

  [★]

  • n.
  • v.
  • 分配する、分割する
allocationcleavagecleavecontingencydealdispensedistributedistributiondividedivisionfractionatefractionationminceparcellatedpartpartedresolutionsplit

WordNet   license wordnet

「divide into parts, pieces, or sections; "The Arab peninsula was partitioned by the British"」
partition off

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「a vertical structure that divides or separates (as a wall divides one room from another)」
divider

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「separate or apportion into sections; "partition a room off"」
zone

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「(computer science) the part of a hard disk that is dedicated to a particular operating system or application and accessed as a single unit」

WordNet   license wordnet

「(anatomy) a structure that separates areas in an organism」

PrepTutorEJDIC   license prepejdic

「〈U〉(‥の)分割,区分《+『of』麥『名』》 / 〈C〉(分割された)部分 / 〈C〉仕切り壁 / (…に)…‘を'分割する,分配する《+『名』+『into』+『名』》 / …‘を'仕切る,区切る《+『off』+『名,』+『名』+『off』》」


blood」

  [★] 血液

WordNet   license wordnet

「smear with blood, as in a hunting initiation rite, where the face of a person is smeared with the blood of the kill」

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「temperament or disposition; "a person of hot blood"」

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「people viewed as members of a group; "we need more young blood in this organization"」

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「the fluid (red in vertebrates) that is pumped through the body by the heart and contains plasma, blood cells, and platelets; "blood carries oxygen and nutrients to the tissues and carries away waste products"; "the ancients believed that blood was the sea」

PrepTutorEJDIC   license prepejdic

「『血』,『血』液 / 流血(bloodshed);殺人 / 気質,気性,血気,血潮 / 『血統』,血縁(kinship);生まれ,家柄;《the~》王家の血統 / (人種・出身国の)系 / 〈人〉‘に'初めての経験をさせる / 〈猟犬〉‘に'初めて獲物を血を味わわせる」


brain」

  [★]


WordNet   license wordnet

「kill by smashing someone''s skull」

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「mental ability; "he''s got plenty of brains but no common sense"」
brainpower, learning ability, mental capacity, mentality, wit

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「that part of the central nervous system that includes all the higher nervous centers; enclosed within the skull; continuous with the spinal cord」
encephalon

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「the brain of certain animals used as meat」

PrepTutorEJDIC   license prepejdic

「『脳』,脳髄 / 《しばしば複数形で》『頭脳』,『知力』 / 《話》秀才,知的指導者 / …‘の'頭を打ち砕く」

WordNet   license wordnet

「hit on the head」


coefficient」

  [★]

  • n.
  • 係数
modulimodulus

WordNet   license wordnet

「a constant number that serves as a measure of some property or characteristic」

PrepTutorEJDIC   license prepejdic

「(数学で)係数,(物理で)係数,率」


blooded」

  [★]

PrepTutorEJDIC   license prepejdic

「純血の,純種の / 《複合語を作って》「…の血(性質)を持った」の意を表す」




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