WordNet
- dull and slow-moving and stolid; like an ox; "showed a bovine apathy"
- any of various members of the genus Bos
- of or relating to or belonging to the genus Bos (cattle) (同)bovid
- malignant neoplasm of blood-forming tissues; characterized by abnormal proliferation of leukocytes; one of the four major types of cancer (同)leukaemia, leucaemia, cancer of the blood
PrepTutorEJDIC
- 牛の;牛のような / のっそりした,鈍重な / ウシ科の動物
- 白血病
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- 1. 急性骨髄性白血病の合併症の概要 overview of the complications of acute myeloid leukemia
- 2. 慢性リンパ性白血病に対する治療の概要 overview of the treatment of chronic lymphocytic leukemia
- 3. 大顆粒T細胞リンパ球性白血病の臨床症状、病理学的特徴、および診断 clinical manifestations pathologic features and diagnosis of t cell large granular lymphocyte leukemia
- 4. 小児および思春期における急性リンパ芽球性白血病の症状および診断の概要 overview of the presentation and diagnosis of acute lymphoblastic leukemia in children and adolescents
- 5. 小児および思春期における急性リンパ芽球性白血病の転帰に関する概要 overview of the outcome of acute lymphoblastic leukemia in children and adolescents
English Journal
- GALNT11 as a new molecular marker in chronic lymphocytic leukemia.
- Libisch MG, Casás M, Chiribao M, Moreno P, Cayota A, Osinaga E, Oppezzo P, Robello C.Author information Molecular Biology Unit, Institut Pasteur de Montevideo, Montevideo, Uruguay.AbstractAberrant mucin O-glycosylation often occurs in different cancers and is characterized by immature expression of simple mucin-type carbohydrates. At present, there are some controversial reports about the Tn antigen (GalNAcα-O-Ser/Thr) expression and there is a great lack of information about the [UDP-N-acetyl-α-d-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-Ts)] expression in chronic lymphocytic leukemia (CLL). To gain insight in these issues we evaluated the Tn antigen expression in CLL patient samples using two Tn binding proteins with different fine specificity. We also studied the expression from 14 GalNAc-Ts genes in CLL patients by RT-PCR. Our results have provided additional information about the expression level of the Tn antigen, suggesting that a low density of Tn residues is expressed in CLL cells. We also found that GALNT11 was expressed in CLL cells and normal T cell whereas little or no expression was found in normal B cells. Based on these results, GALNT11 expression was assessed by qPCR in a cohort of 50 CLL patients. We found significant over-expression of GALNT11 in 96% of B-CLL cells when compared to normal B cells. Moreover, we confirmed the expression of this enzyme at the protein level. Finally we found that GALNT11 expression was significantly associated with the mutational status of the immunoglobulin heavy chain variable region (IGHV), [א(2)(1)=18.26; P<0.0001], lipoprotein lipase expression [א(2)(1)=13.72; P=0.0002] and disease prognosis [א(2)(1)=15.49; P<0.0001]. Our evidence suggests that CLL patient samples harbor aberrant O-glycosylation highlighted by Tn antigen expression and that the over-expression of GALNT11 constitutes a new molecular marker for CLL.
- Gene.Gene.2014 Jan 1;533(1):270-9. doi: 10.1016/j.gene.2013.09.052. Epub 2013 Sep 27.
- Aberrant mucin O-glycosylation often occurs in different cancers and is characterized by immature expression of simple mucin-type carbohydrates. At present, there are some controversial reports about the Tn antigen (GalNAcα-O-Ser/Thr) expression and there is a great lack of information about the [U
- PMID 24076351
- An Avian Retrovirus Uses Canonical Expression and Processing Mechanisms To Generate Viral MicroRNA.
- Yao Y, Smith LP, Nair V, Watson M.Author information Viral Oncogenesis Group, The Pirbright Institute, Compton Laboratory, Compton, Berkshire, United Kingdom.AbstractTo date, the vast majority of known virus-encoded microRNAs (miRNAs) are derived from polymerase II transcripts encoded by DNA viruses. A recent demonstration that the bovine leukemia virus, a retrovirus, uses RNA polymerase III to directly transcribe the pre-miRNA hairpins to generate viral miRNAs further supports the common notion that the canonical pathway of miRNA biogenesis does not exist commonly among RNA viruses. Here, we show that an exogenous virus-specific region, termed the E element or XSR, of avian leukosis virus subgroup J (ALV-J), a member of avian retrovirus, encodes a novel miRNA, designated E (XSR) miRNA, using the canonical miRNA biogenesis pathway. Detection of novel microRNA species derived from the E (XSR) element, a 148-nucleotide noncoding RNA with hairpin structure, showed that the E (XSR) element has the potential to function as a microRNA primary transcript, demonstrating a hitherto unknown function with possible roles in myeloid leukosis associated with ALV-J.
- Journal of virology.J Virol.2014 Jan;88(1):2-9. doi: 10.1128/JVI.02921-13. Epub 2013 Oct 23.
- To date, the vast majority of known virus-encoded microRNAs (miRNAs) are derived from polymerase II transcripts encoded by DNA viruses. A recent demonstration that the bovine leukemia virus, a retrovirus, uses RNA polymerase III to directly transcribe the pre-miRNA hairpins to generate viral miRNAs
- PMID 24155381
- Suppression of SERPINA1-albumin complex formation by galectin-3 overexpression leads to paracrine growth promotion of chronic myelogenous leukemia cells.
- Nakayama R1, Kuroda J2, Taniyama N3, Yamamoto-Sugitani M1, Wada S3, Kiyota M1, Mizutani S1, Chinen Y1, Matsumoto Y1, Nagoshi H1, Shimura Y1, Kobayashi T1, Horiike S1, Sato K3, Taniwaki M1.Author information 1Division of Hematology and Oncology, Department of Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan.2Division of Hematology and Oncology, Department of Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan. Electronic address: junkuro@koto.kpu-m.ac.jp.3Division of Applied Life Sciences, Graduate School of Life and Environmental Sciences, Kyoto Prefectural University, Kyoto, Japan.AbstractGalectin-3 is induced in chronic myelogenous leukemia (CML) cells by co-culture with bone marrow stromal cells, making paracrine growth promotion of CML cells in conditioned medium (CM) from galectin-3 overexpressing CML cells more potent. We used gel filtration chromatography to demonstrate that the bovine SERPINA1-fetal bovine serum albumin (BSA) complex was specifically suppressed in CM from galectin-3 overexpressing cells. The SERPINA1-BSA complex as well as human plasma SERPINA1 inhibited the growth of CML cells, while exogenous galectin-3 partly offset this effect. These findings suggest that galectin-3 overexpression promotes paracrine growth of CML cells by interfering with the action of the growth inhibitory SERPINA1-albumin complex.
- Leukemia research.Leuk Res.2014 Jan;38(1):103-8. doi: 10.1016/j.leukres.2013.07.026. Epub 2013 Aug 13.
- Galectin-3 is induced in chronic myelogenous leukemia (CML) cells by co-culture with bone marrow stromal cells, making paracrine growth promotion of CML cells in conditioned medium (CM) from galectin-3 overexpressing CML cells more potent. We used gel filtration chromatography to demonstrate that th
- PMID 23953881
Japanese Journal
- Nationwide Survey of Bovine Leukemia Virus Infection among Dairy and Beef Breeding Cattle in Japan from 2009–2011
- MURAKAMI Kenji,KOBAYASHI Sota,KONISHI Misako [他]
- The journal of veterinary medical science 75(8), 1123-1126, 2013-08
- NAID 40019791045
- Expression analysis of Foxp3 in T cells from bovine leukemia virus infected cattle
- Suzuki Saori,Konnai Satoru,Okagawa Tomohiro [他]
- Microbiology and immunology 57(8), 600-604, 2013-08
- NAID 40019751354
- 農林水産省経営局長賞・吉田賞 管内一酪農家における牛白血病浸潤状況と清浄化への取り組み (平成24年度家畜診療等技術全国研究集会・入賞論文)
- 田中 秀和,大慈 祐介,松浦 優 [他]
- 家畜診療 = Journal of livestock medicine 60(6), 359-365, 2013-06
- NAID 40019700377
Related Links
- leukemia /leu·ke·mia/ (loo-ke´me-ah) a progressive, malignant disease of the blood-forming organs, marked by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow.leuke´mic acute ...
- Bovine leukemia virus (BLV) is a bovine virus closely related to HTLV-I, a human tumour virus. The main hosts for the virus are cows. BLV is a retrovirus which integrates a DNA intermediate as a provirus into the DNA of B ...
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★リンクテーブル★
| リンク元 | 「ウシ白血病」「bovine lymphoma」「enzootic bovine leukosis」「bovine leukosis」 |
| 拡張検索 | 「bovine leukemia virus」 |
| 関連記事 | 「bovine」 |
「ウシ白血病」
「bovine lymphoma」
「enzootic bovine leukosis」
「bovine leukosis」
「bovine leukemia virus」
- 関
- BLV
「bovine」
- ウシの