骨リモデリング
WordNet
- remove the bones from; "bone the turkey before roasting it" (同)debone
- the porous calcified substance from which bones are made (同)osseous_tissue
- consisting of or made up of bone; "a bony substance"; "the bony framework of the body"
- a shade of white the color of bleached bones (同)ivory, pearl, off-white
- rigid connective tissue that makes up the skeleton of vertebrates (同)os
- having bones as specified; "his lanky long-boned body"
- having had the bones removed; "a boneless rib roast"; "a boned (or deboned) fish" (同)deboned
- a percussion instrument consisting of a pair of hollow pieces of wood or bone (usually held between the thumb and fingers) that are made to click together (as by Spanish dancers) in rhythm with the dance (同)castanets, clappers, finger cymbals
PrepTutorEJDIC
- 〈C〉骨 / 〈U〉骨を作っている物質,骨質 / 《複数形で》骨格;死骸(がい) / 〈魚など〉‘の'骨を取る
- (魚など)骨を取り除いた / (衣服が)(コルセットなどで)骨で張りをつけた[ような]
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/01/13 11:21:47」(JST)
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This article needs additional citations for verification. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed. (February 2010) |
Bone tissue is removed by osteoclasts, and then new bone tissue is formed by osteoblasts. Both processes utilize cytokine (TGF-β, IGF) signalling.
Bone remodeling (or bone metabolism) is a lifelong process where mature bone tissue is removed from the skeleton (a process called bone resorption) and new bone tissue is formed (a process called ossification or new bone formation). These processes also control the reshaping or replacement of bone following injuries like fractures but also micro-damage, which occurs during normal activity. Remodeling responds also to functional demands of the mechanical loading.
In the first year of life, almost 100% of the skeleton is replaced. In adults, remodeling proceeds at about 10% per year.[1]
An imbalance in the regulation of bone remodeling's two sub-processes, bone resorption and bone formation, results in many metabolic bone diseases, such as osteoporosis.[2]
Physiology
The cells responsible for bone metabolism are known as osteoblasts, which secrete new bone, and osteoclasts which break bone down. The structure of bones as well as adequate supply of calcium requires close cooperation between these two types of cells. It relies on complex signaling pathways to achieve proper rates of growth and differentiation. These signaling pathways include the action of several hormones, including parathyroid hormone (PTH), vitamin D, growth hormone, steroids, and calcitonin, as well as several cytokines. It is in this way that the body is able to maintain proper levels of calcium required for physiological processes.
Subsequent to appropriate signaling, osteoclasts move to resorb the surface of the bone, followed by deposition of bone by osteoblasts. Together, the cells that are responsible for bone remodeling are known as the basic multicellular unit (BMU), and the temporal duration (i.e. lifespan) of the BMU is referred to as the bone remodeling period.[3]
Gallery
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Osteoblasts actively synthesizing osteoid containing two osteocytes.
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Osteoclast, with bone below it, showing typical distinguishing characteristics: a large cell with multiple nuclei and a "foamy" cytosol.
References
- ^ Wheeless Textbook
- ^ Online Medical Dictionary
- ^ Pietrzak, WS. Musculoskeletal tissue regeneration: biological materials and methods, Humana Press, 2008. ISBN 1-58829-909-0 page 48
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Musculoskeletal physiology: Bone/cartilage physiology
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| Bone |
- Bone density
- Bone remodeling
- Bone healing
- Bone resorption
- Osseointegration
- Ossification
- Osteolysis
- Bone age
- Periosteal reaction
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| Cartilage |
Chondrogenesis
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| Joint |
Range of motion
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| Teeth |
- Mastication
- Cementogenesis
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anat (c/f/k/f, u, t/p, l)/phys/devp/cell
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noco/cong/tumr, sysi/epon, injr
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noco (arth/defr/back/soft)/cong, sysi/epon, injr
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noco/cong/jaws/tumr, epon, injr
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dent, proc (endo, orth, pros)
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UpToDate Contents
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English Journal
- Peripheral Blood Mononuclear Cells Spontaneous Osteoclastogenesis: Mechanisms Driving the Process and Clinical Relevance in Skeletal Disease.
- Salamanna F1, Maglio M2, Borsari V1, Giavaresi G1,2,3, Aldini NN1,2, Fini M1,2.
- Journal of cellular physiology.J Cell Physiol.2016 Mar;231(3):521-30. doi: 10.1002/jcp.25134. Epub 2015 Sep 9.
- In vitro peripheral blood mononuclear cells differentiate into osteoclasts under the influence of osteoclast-stimulating factors. However, accumulating evidence suggests spontaneous osteoclasts formation and activity in patients affected by local or systemic bone remodeling diseases in comparison wi
- PMID 26284737
- Bone remodeling in psoriasis and psoriatic arthritis: an update.
- Paine A1, Ritchlin C.
- Current opinion in rheumatology.Curr Opin Rheumatol.2016 Jan;28(1):66-75. doi: 10.1097/BOR.0000000000000232.
- PURPOSE OF REVIEW: This article reviews and outlines recent advances in the field of bone remodeling in psoriatic disease and identify avenues for further research.RECENT FINDINGS: High-resolution imaging revealed that new bone formation, observed in psoriatic arthritis (PsA) is centered at enthesia
- PMID 26555451
- Effects of magnesium degradation products on mesenchymal stem cell fate and osteoblastogenesis.
- Luthringer BJ1, Willumeit-Römer R2.
- Gene.Gene.2016 Jan 1;575(1):9-20. doi: 10.1016/j.gene.2015.08.028. Epub 2015 Aug 15.
- The unique properties of magnesium (Mg) and its alloys that combine favourable mechanical properties, biocompatibility, and biodegradability, which until now have been restricted primarily to polymers, justify its study in the field of implantology. Previous in vivo studies have underlined the possi
- PMID 26283150
Japanese Journal
- Plasma fluctuation in estradiol-17β and bone resorption markers around parturition in dairy cows
- DEVKOTA Bhuminad,TAKAHASHI Masahiro,SATO Saori [他]
- The journal of veterinary medical science 77(7), 875-878, 2015-07
- NAID 40020548220
- 矯正学的歯の移動における骨リモデリングの三次元非線形有限要素解析
- Effects of Total Hip Arthroplasty on Stress Adaptation and Bone Remodeling in Lower Limbs
- Abdullah Abdul Halim,Todo Mitsugu
- Evergreen : joint journal of Novel Carbon Resource Sciences & Green Asia Strategy 2(1), 6-11, 2015-03
- NAID 40020438270
Related Links
- 1. Ann N Y Acad Sci. 2006 Dec;1092:385-96. Bone remodeling. Hadjidakis DJ(1), Androulakis II. Author information: (1)Second Department of Internal Medicine, Propaedeutic and Research Institute, Athens ...
- Bone remodeling, bone remodeling Encyclopædia Britannica, Inc. continuing process of synthesis and destruction that gives bone its mature structure and maintains normal calcium levels in the body. Destruction, or resorption, of bone ...
★リンクテーブル★
[★]
- 英
- remodeling、remodelling
- 関
- 再構築、再造形、組織修復
- bone remodeling
[★]
骨