blood brain barrier

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/04/08 00:49:37」(JST)

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英文文献

  • Production, characterization and applications of a tetanus toxin specific monoclonal antibody T-62.
  • Petrušić V, Zivković I, Stojanović M, Stojićević I, Marinković E, Dimitrijević L.SourceInstitute of Virology, Vaccines and Sera - Torlak, Department of Research and Development, Vojvode Stepe 458, 11221 Belgrade, Serbia.
  • Acta histochemica.Acta Histochem.2012 Sep;114(5):480-6. Epub 2011 Oct 4.
  • Tetanus neurotoxin (TeNT) represents a potent toxin that binds to its receptors on neurons and inhibits the release of neurotransmitters. Additionally, its fragments are used to transport pharmacological substances to neuronal cell bodies. The main objective of this study was the development of a su
  • PMID 21975055
  • Experimental Methods and Transport Models for Drug Delivery across the Blood-Brain Barrier.
  • Fu BM.SourceDepartment of Biomedical Engineering, The City College of the City University of New York, 160 Convent Ave., New York, NY 10031 USA. fu@ccny.cuny.edu.
  • Current pharmaceutical biotechnology.Curr Pharm Biotechnol.2012 Sep 1. [Epub ahead of print]
  • The blood-brain barrier (BBB) is a dynamic barrier essential for maintaining the micro-environment of the brain. Although the special anatomical features of the BBB determine its protective role for the central nervous system (CNS) from blood-born neurotoxins, however, the BBB extremely limits the t
  • PMID 22201587
  • Ultrasound-Induced Blood-Brain Barrier Opening.
  • Konofagou EE, Tung YS, Choi J, Deffieux T, Baseri B, Vlachos F.SourceDepartment of Biomedical Engineering, Columbia University, New York, NY. ek2191@columbia.edu.
  • Current pharmaceutical biotechnology.Curr Pharm Biotechnol.2012 Sep 1. [Epub ahead of print]
  • Over 4 million U.S. men and women suffer from Alzheimer's disease; 1 million from Parkinson's disease; 350,000 from multiple sclerosis (MS); and 20,000 from amyotrophic lateral sclerosis (ALS). Worldwide, these four diseases account for more than 20 million patients. In addition, aging greatly incre
  • PMID 22201586
  • Precise glioma targeting of and penetration by aptamer and peptide dual-functioned nanoparticles.
  • Gao H, Qian J, Cao S, Yang Z, Pang Z, Pan S, Fan L, Xi Z, Jiang X, Zhang Q.SourceKey Laboratory of Smart Drug Delivery, Ministry of Education & PLA, School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai 201203, China.
  • Biomaterials.Biomaterials.2012 Jul;33(20):5115-23. Epub 2012 Apr 6.
  • The treatment of a brain glioma is still one of the most difficult challenges in oncology. To effectively treat brain glioma and reduce the side effects, drugs must be transported across the blood brain barrier (BBB) and then targeted to the brain cancer cells because most anti-tumor drugs are highl
  • PMID 22484043

和文文献

  • 〈Review〉Target validation and drug discovery for in flammatory diseases
  • Takahashi Hideo Kohka
  • Acta Medica Kinki University 36(2), 45-52, 2011-12
  • [Abstract] We have examined to find new factors, which are involved in inflammatory diseases including ischemic diseases. To investigate the mechanism of inflammation, we have proved that monocyte/mac …
  • NAID 120003753061
  • Synthesis and characterization of [(125)I]2-iodo N-[(S)-{(S)-1-methylpiperidin-2-yl}(phenyl)methyl]3-trifluoromethyl-benzamide as novel imaging probe for glycine transporter 1.
  • Fuchigami Takeshi,Haratake Mamoru,Magata Yasuhiro,Haradahira Terushi,Nakayama Morio
  • Bioorganic & Medicinal Chemistry 19(21), 6245-6253, 2011-11-01
  • … In the biodistribution and ex vivo autoradiography studies using mice, [(125)I]5 showed high blood-brain barrier permeability (1.68-2.17% dose/g at 15-60min) and similar regional brain distribution pattern with in vitro results. …
  • NAID 120003496559
  • Therapeutic Approaches to Vascular Protection in Ischemic Stroke
  • Yamashita Toru,Abe Koji
  • Acta Medica Okayama 65(4), 219-223, 2011-08
  • … Reperfusion with recombinant tissue plasminogen activator (tPA) sometimes causes catastrophic hemorrhagic transformation (HT) in the ischemic brain. … Recent studies have indicated that matrix metalloproteinases (MMPs), especially MMP-9, play a critical role in blood brain barrier (BBB) disruption in the ischemic brain, leading to brain edema and HT. …
  • NAID 80021895203
  • Neurovascular Coupling in Cognitive Impairment Associated With Diabetes Mellitus
  • MOGI Masaki,HORIUCHI Masatsugu
  • Circulation journal : official journal of the Japanese Circulation Society 75(5), 1042-1048, 2011-04-25
  • … Because patients with diabetes have various complications of vascular disease, with not only macrovascular but also microvascular disorders, vascular disorders in the brain are considered to be one of the mechanisms in diabetes-induced cognitive impairment. … Indeed, disruption of the blood-brain barrier (BBB) has been observed in some diabetic patients and experimental diabetes models. …
  • NAID 10028147092

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★リンクテーブル★
リンク元血液脳関門
拡張検索blood-brain barrier
関連記事blood」「barrier」「brain」「blooded」「bra

血液脳関門」

  [★]

blood brain barrier,blood-brain barrier, BBB
血液-脳関門
胎盤関門血液空気関門


概念

  • 図:SCN.146(血液脳関門が存在しない部位)
  • 脂溶性の物質は通過しやすい
  • アストロサイトは血管周囲を連続的に覆って層を形成し、血液脳関門を維持している (HIS.166)
  • 脳の血管内皮細胞から排出ポンプであるP-glycoproteinが薬物を除去している (HAR.30,32f)

血液脳関門が存在しない部位

新生児における血液脳関門の機能低下(SPE.110)

  • 未熟性、低酸素血症、アシドーシス、低血糖など 
→ 核黄疸(ビリルビン脳症)のリスクファクター (G10M.331)


blood-brain barrier」

  [★]

血液脳関門, BBB
BBB


blood」

  [★] 血液

WordNet   license wordnet

「smear with blood, as in a hunting initiation rite, where the face of a person is smeared with the blood of the kill」

WordNet   license wordnet

「temperament or disposition; "a person of hot blood"」

WordNet   license wordnet

「people viewed as members of a group; "we need more young blood in this organization"」

WordNet   license wordnet

「the fluid (red in vertebrates) that is pumped through the body by the heart and contains plasma, blood cells, and platelets; "blood carries oxygen and nutrients to the tissues and carries away waste products"; "the ancients believed that blood was the sea」

PrepTutorEJDIC   license prepejdic

「『血』,『血』液 / 流血(bloodshed);殺人 / 気質,気性,血気,血潮 / 『血統』,血縁(kinship);生まれ,家柄;《the~》王家の血統 / (人種・出身国の)系 / 〈人〉‘に'初めての経験をさせる / 〈猟犬〉‘に'初めて獲物を血を味わわせる」


barrier」

  [★]

  • n.
damagedifficultydisorderdisturbancedysfunctionfoehindranceimpairimpairmentimpedimentlesionobstacle

WordNet   license wordnet

「a structure or object that impedes free movement」

WordNet   license wordnet

「any condition that makes it difficult to make progress or to achieve an objective; "intolerance is a barrier to understanding"」
roadblock

WordNet   license wordnet

「anything serving to maintain separation by obstructing vision or access」

PrepTutorEJDIC   license prepejdic

「(通行をはばむ)『さく』,『障壁』;関門;《ふざけて》改札口 / (…の)『難関』,障害《+『to』+『名』》」


brain」

  [★]


WordNet   license wordnet

「kill by smashing someone''s skull」

WordNet   license wordnet

「mental ability; "he''s got plenty of brains but no common sense"」
brainpower, learning ability, mental capacity, mentality, wit

WordNet   license wordnet

「that part of the central nervous system that includes all the higher nervous centers; enclosed within the skull; continuous with the spinal cord」
encephalon

WordNet   license wordnet

「the brain of certain animals used as meat」

PrepTutorEJDIC   license prepejdic

「『脳』,脳髄 / 《しばしば複数形で》『頭脳』,『知力』 / 《話》秀才,知的指導者 / …‘の'頭を打ち砕く」

WordNet   license wordnet

「hit on the head」

blooded」

  [★]

PrepTutorEJDIC   license prepejdic

「純血の,純種の / 《複合語を作って》「…の血(性質)を持った」の意を表す」

bra」

  [★]

PrepTutorEJDIC   license prepejdic

「=brassiere, brassiere」




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