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1. 正常ヒトヘモグロビンの構造および機能 structure and function of normal human hemoglobins
2. 先天性赤血球増多症および真性多血症の分子学的病因 molecular pathogenesis of congenital polycythemic disorders and polycythemia vera
3. 成人における赤血球輸血：保管、専門的調整、および輸血パラメータ red blood cell transfusion in adults storage specialized modifications and infusion parameters
4. 妊娠中の血液学的変化 hematologic changes in pregnancy
5. 鎌状ヘモグロビン多量体：構造と機能特性 sickle hemoglobin polymer structure and functional properties

English Journal

TIGAR's promiscuity.

Bolaños JP.
The Biochemical journal.Biochem J.2014 Mar 15;458(3):e5-7. doi: 10.1042/BJ20140087.
TIGAR [TP53 (tumour protein 53)-induced glycolysis and apoptosis regulator] protein is known for its ability to inhibit glycolysis, shifting glucose consumption towards the pentose phosphate pathway to promote antioxidant protection of cancer cells. According to sequence homology and activity analys
PMID 24576095

Identification of TP53-induced glycolysis and apoptosis regulator (TIGAR) as the phosphoglycolate-independent 2,3-bisphosphoglycerate phosphatase.

Gerin I, Noël G, Bolsée J, Haumont O, Van Schaftingen E, Bommer GT.
The Biochemical journal.Biochem J.2014 Mar 15;458(3):439-48. doi: 10.1042/BJ20130841.
The p53-induced protein TIGAR [TP53 (tumour protein 53)-induced glycolysis and apoptosis regulator] is considered to be a F26BPase (fructose-2,6-bisphosphatase) with an important role in cancer cell metabolism. The reported catalytic efficiency of TIGAR as an F26BPase is several orders of magnitude
PMID 24423178

Insights into the phosphatase and the synthase activities of human bisphosphoglycerate mutase: a quantum mechanics/molecular mechanics simulation.

Chu WT1, Zheng QC, Zhang HX.
Physical chemistry chemical physics : PCCP.Phys Chem Chem Phys.2014 Mar 7;16(9):3946-54. doi: 10.1039/c3cp53935k.
Bisphosphoglycerate mutase (BPGM) is a multi-activity enzyme. Its main function is to synthesize the 2,3-bisphosphoglycerate, the allosteric effector of hemoglobin. This enzyme can also catalyze the 2,3-bisphosphoglycerate to the 3-phosphoglycerate. In this study, the reaction mechanisms of both the
PMID 24441588

Japanese Journal

The bifunctional glyceryl transferase/phosphatase OzmB belonging to the HAD superfamily that diverts 1,3-bisphosphoglycerate into polyketide biosynthesis

DORRESTEIN PC
J Am Chem Soc 128, 10386-10387, 2006
NAID 30011177602

補酵素NADモデル分子を用いた生体酸化・不斉還元モデル反応

鹿又宣弘
有機合成化学協会誌 57(6), 512-522, 1999-06-01
… Coenzyme NAD<SUP>+</SUP>/NADH, a major cofactor of dehydrogenases, functions as an autorecycling redox agent in biological systems, which is exemplified by enantioselective reduction of pyruvate to L-lactate and oxidation of glyceraldehyde-3-phosphate to 1, 3-bisphosphoglycerate as is observed in anaerobic glycolysis. …
NAID 10009347966

Model of 2,3-bisphosphoglycerate metabolism in the human erythrocyte based on detailed enzyme kinetic equations : computer simulation and metabolic control analysis

MULQUINEY P
Biochem J 342, 597-604, 1999
NAID 30014337928

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Role of 2,3-bisphosphoglycerate (2,3-BPG) Bisphosphoglycerate is a negative Bisphosphoglycerate mutase 描述 2,3-Bisphosphoglycerate.gif bisphosphoglycerate compound (also Oxidation & Synthesis of ATP Under