biological marker

出典: meddic

biochemical markerbiologic markerbiomarkerclinical markerimmune markerimmunologic markerserum markersurrogate end point、surrogate endpoint、surrogate marker

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2014/03/03 13:59:04」(JST)

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英文文献

  • Evidence and uptake routes for Zinc oxide nanoparticles through the gastrointestinal barrier in Xenopus laevis.
  • Bacchetta R, Moschini E, Santo N, Fascio U, Del Giacco L, Freddi S, Camatini M, Mantecca P.Author information Department of Biosciences, Università degli Studi di Milano , Milano , Italy.AbstractThe developmental toxicity of nanostructured materials, as well as their impact on the biological barriers, represents a crucial aspect to be assessed in a nanosafety policy framework. Nanosized metal oxides have been demonstrated to affect Xenopus laevis embryonic development, with nZnO specifically targeting the digestive system. To study the mechanisms of the nZnO-induced intestinal lesions, we tested two different nominally sized ZnO nanoparticles (NPs) at effective concentrations. Advanced microscopy techniques and molecular marker analyses were applied in order to describe the NP-epithelial cell interactions and the mechanisms driving NP toxicity and translocation through the intestinal barrier. We attributed the toxicity to NP-induced cell oxidative damage, the small-sized NPs being the more effective. This outcome is sustained by a marked increase in anti-oxidant genes' expression and high lipid peroxidation level in the enterocytes, where disarrangement of the cytoskeleton and cell junctions' integrity were evidenced. These events led to diffuse necrotic changes in the intestinal barrier, and trans- and paracellular NP permeation through the mucosa. The uptake routes, leading NPs to cross the intestinal barrier and reach secondary target tissues, have been documented. nZnOs embryotoxicity was confirmed to be crucially mediated by the NPs' reactivity rather than their dissolved ions. The ZnO NPs' ability to overwhelm the intestinal barrier must be taken into high consideration for a future design of safer ZnO NPs.
  • Nanotoxicology.Nanotoxicology.2014 Nov;8(7):728-44. doi: 10.3109/17435390.2013.824128. Epub 2013 Aug 6.
  • The developmental toxicity of nanostructured materials, as well as their impact on the biological barriers, represents a crucial aspect to be assessed in a nanosafety policy framework. Nanosized metal oxides have been demonstrated to affect Xenopus laevis embryonic development, with nZnO specificall
  • PMID 23848496
  • An integrated approach utilising chemometrics and GC/MS for classification of chamomile flowers, essential oils and commercial products.
  • Wang M1, Avula B1, Wang YH1, Zhao J1, Avonto C1, Parcher JF1, Raman V1, Zweigenbaum JA2, Wylie PL2, Khan IA3.Author information 1National Center for Natural Products Research, University of Mississippi, MS 38677, USA.2Agilent Technologies, 2850 Centerville Rd., Wilmington, DE 19808-1610, USA.3National Center for Natural Products Research, University of Mississippi, MS 38677, USA; Department of Pharmacognosy, School of Pharmacy, University of Mississippi, MS 38677, USA; Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia. Electronic address: ikhan@olemiss.edu.AbstractAs part of an ongoing research program on authentication, safety and biological evaluation of phytochemicals and dietary supplements, an in-depth chemical investigation of different types of chamomile was performed. A collection of chamomile samples including authenticated plants, commercial products and essential oils was analysed by GC/MS. Twenty-seven authenticated plant samples representing three types of chamomile, viz. German chamomile, Roman chamomile and Juhua were analysed. This set of data was employed to construct a sample class prediction (SCP) model based on stepwise reduction of data dimensionality followed by principle component analysis (PCA) and partial least squares discriminant analysis (PLS-DA). The model was cross-validated with samples including authenticated plants and commercial products. The model demonstrated 100.0% accuracy for both recognition and prediction abilities. In addition, 35 commercial products and 11 essential oils purported to contain chamomile were subsequently predicted by the validated PLS-DA model. Furthermore, tentative identification of the marker compounds correlated with different types of chamomile was explored.
  • Food chemistry.Food Chem.2014 Jun 1;152:391-8. doi: 10.1016/j.foodchem.2013.11.118. Epub 2013 Dec 4.
  • As part of an ongoing research program on authentication, safety and biological evaluation of phytochemicals and dietary supplements, an in-depth chemical investigation of different types of chamomile was performed. A collection of chamomile samples including authenticated plants, commercial product
  • PMID 24444953
  • Multi-nanomaterial electrochemical biosensor based on label-free graphene for detecting cancer biomarkers.
  • Jin B1, Wang P1, Mao H2, Hu B3, Zhang H4, Cheng Z1, Wu Z1, Bian X4, Jia C4, Jing F4, Jin Q4, Zhao J4.Author information 1State Key Laboratory of Transducer Technology, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Science, Shanghai 200050, China; University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing 100049, China.2State Key Laboratory of Transducer Technology, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Science, Shanghai 200050, China. Electronic address: hjmao@mail.sim.ac.cn.3Clinical Research Center of Biological Sensing Technology, Shanghai Xuhui Central Hospital, Shanghai 200040, China.4State Key Laboratory of Transducer Technology, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Science, Shanghai 200050, China.AbstractDeveloping a rapid, accurate and sensitive electrochemical biosensor for detecting cancer biomarkers is important for early detection and diagnosis. This work reports an electrochemical biosensor based on a graphene (GR) platform which is made by CVD, combined with magnetic beads (MBs) and enzyme-labeled antibody-gold nanoparticle bioconjugate. MBs coated with capture antibodies (Ab1) were attached to GR sheets by an external magnetic field, to avoid reducing the conductivity of graphene. Sensitivity was also enhanced by modifying the gold nanoparticles (AuNPs) with horseradish peroxidase (HRP) and the detection antibody (Ab2), to form the conjugate Ab2-AuNPs-HRP. Electron transport between the electrode and analyte target was accelerated by the multi-nanomaterial, and the limit of detection (LOD) for carcinoembryonic antigen (CEA) reached 5ngmL(-1). The multi-nanomaterial electrode GR/MBs-Ab1/CEA/Ab2-AuNPs-HRP can be used to detect biomolecules such as CEA. The EC biosensor is sensitive and specific, and has potential in the detection of disease markers.
  • Biosensors & bioelectronics.Biosens Bioelectron.2014 May 15;55:464-9. doi: 10.1016/j.bios.2013.12.025. Epub 2013 Dec 19.
  • Developing a rapid, accurate and sensitive electrochemical biosensor for detecting cancer biomarkers is important for early detection and diagnosis. This work reports an electrochemical biosensor based on a graphene (GR) platform which is made by CVD, combined with magnetic beads (MBs) and enzyme-la
  • PMID 24462797

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★リンクテーブル★
リンク元surrogate end point」「biochemical marker」「surrogate marker」「生物学的マーカー」「biologic marker
関連記事mark」「marker」「biological」「biologic

surrogate end point」

  [★]

代替エンドポイントサロゲートエンドポイント

biochemical markerbiologic markerbiological markerbiomarkerclinical markerimmune markerimmunologic markerserum marker、surrogate endpoint、surrogate marker


biochemical marker」

  [★]

biologic markerbiological markerbiomarkerclinical markerimmune markerimmunologic markerserum markersurrogate end point、surrogate endpoint、surrogate marker


surrogate marker」

  [★]

biochemical markerbiologic markerbiological markerbiomarkerclinical markerimmune markerimmunologic markerserum markersurrogate end point、surrogate endpoint

生物学的マーカー」

  [★]

biological markerbiologic marker
生物マーカー生化学マーカー代用マーカー臨床マーカー免疫マーカー血清マーカー、代替エンド・イント、代替マーカー


biologic marker」

  [★]

biochemical markerbiological markerbiomarkerclinical markerimmune markerimmunologic markerserum markersurrogate end point、surrogate endpoint、surrogate marker


mark」

  [★]

  • n.
  • v.
characterisecharacterizelabellabelinglandmarkmarkermarkingtag

WordNet   license wordnet

「make or leave a mark on; "the scouts marked the trail"; "ash marked the believers'' foreheads"」

WordNet   license wordnet

「formerly the basic unit of money in Germany」
German mark, Deutsche Mark, Deutschmark

WordNet   license wordnet

「the impression created by doing something unusual or extraordinary that people notice and remember; "it was in London that he made his mark"; "he left an indelible mark on the American theater"」

WordNet   license wordnet

「a number or letter indicating quality (especially of a student''s performance); "she made good marks in algebra"; "grade A milk"; "what was your score on your homework?"」
grade, score

WordNet   license wordnet

「a visible indication made on a surface; "some previous reader had covered the pages with dozens of marks"; "paw prints were everywhere"」
print

WordNet   license wordnet

「a symbol of disgrace or infamy; "And the Lord set a mark upon Cain"--Genesis」
stigma, brand, stain

WordNet   license wordnet

「a written or printed symbol (as for punctuation); "his answer was just a punctuation mark"」

PrepTutorEJDIC   license prepejdic

「〈C〉(…の表面についた)『跡』,汚れ,はん点《+『on』+『名』》 / 〈C〉『印』,記号,符号,標章 / 〈C〉《おもに英》(学業などの)『点数』,成績,評価,(…の)得点《+『in』(『for』)+『名』》 / 〈C〉(ある性質の)『徴候』,『特徴』,現れ,様相《+『of』+『名』》 / 〈C〉(思想・生活などに及ぼす)『影響』,感化《+『on』+『名』》 / 〈C〉(境界などの)位置を示すもの,指標,目印 / 〈C〉『的』,標的 / 〈C〉《the mark》水準,標準 / 〈U〉《文》著名,重要性;名声 / 〈C〉(軽べつ・もの笑いなどの)対象,的 / 〈U〉《通例M-》武器記号,…型 / 〈C〉スタートライン / (…で)…‘に'『印をつける』,跡をつける《+『名』++『with』+『名』》 / 〈物が〉…‘を'印となっている,‘を'示している / …‘を'印(記号など)で示す / 〈物・事柄などが〉…‘を'『特徴づける』,目立たせる / 〈答案など〉‘に'点(印)をつける / (…の候補に)…‘を'選び出す《+『名』+『out for』+『名』》 / …‘に'注意を払う,柱目する」

PrepTutorEJDIC   license prepejdic

「マルク(ドイツノ貨幣単位;《略》『MK.』)」

WordNet   license wordnet

「designate as if by a mark; "This sign marks the border"」


marker」

  [★]

  • n.
labellabelinglandmarkmarkmarkingtag

WordNet   license wordnet

「a writing implement for making a mark」

WordNet   license wordnet

「some conspicuous object used to distinguish or mark something; "the buoys were markers for the channel"」

WordNet   license wordnet

「a distinguishing symbol; "the owner''s mark was on all the sheep"」
marking, mark

PrepTutorEJDIC   license prepejdic

「印をつける人(道具) / (ゲームなどの)採点者 / 目印,目標」


biological」

  [★]

  • adj.
  • 生物学的な、生物学の、生物学上の、生物の
biolbiologicbiologicallybiologybioticfleshorganism

WordNet   license wordnet

「of parents and children; related by blood; "biological child"」

WordNet   license wordnet

「pertaining to biology or to life and living things」
biologic


biologic」

  [★]

  • adj.
  • 生物学的な、生物学の、生物学上の、生物の
biolbiologicalbiologicallybiologybioticfleshorganism




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