biliary obstruction

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/12/04 23:25:40」(JST)

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英文文献

  • Endoscopic ultrasound-guided biliary drainage: an update.
  • Kumta NA1, Kedia P, Kahaleh M.Author information 1Division of Gastroenterology and Hepatology, Weill Cornell Medical College, New York, NY, 10021, USA.AbstractOPINION STATEMENT: Endoscopic retrograde cholangiopancreatography (ERCP) is currently the preferred procedure for biliary drainage in both benign and malignant obstructions. While ERCP is successful in approximately 95 % of cases, a small subset of cases are unsuccessful due to variant anatomy, ampullary pathology, or malignant luminal obstruction. Endoscopic ultrasound-guided biliary drainage (EUS-BD) is a promising route for biliary decompression that provides multiple advantages over percutaneous and surgical biliary drainage. Multiple retrospective as well as some prospective studies have shown EUS-BD to be safe and effective. Based on the current literature, the cumulative success rate is 84-93 %, regardless of the approach, with an overall complication rate of 16-35 %. EUS-BD appears to a viable therapeutic modality for failed ERCP when performed by highly skilled advanced endoscopists at tertiary centers with expertise in both echo-endoscopy and biliary endoscopy. Larger prospective multicenter randomized comparative studies are needed to further define indications, outcomes, and complications.
  • Current treatment options in gastroenterology.Curr Treat Options Gastroenterol.2014 Jun;12(2):154-68. doi: 10.1007/s11938-014-0011-1.
  • OPINION STATEMENT: Endoscopic retrograde cholangiopancreatography (ERCP) is currently the preferred procedure for biliary drainage in both benign and malignant obstructions. While ERCP is successful in approximately 95 % of cases, a small subset of cases are unsuccessful due to variant anatomy, amp
  • PMID 24623591
  • The effect of acetaminophen on the expression of BCRP in trophoblast cells impairs the placental barrier to bile acids during maternal cholestasis.
  • Blazquez AG1, Briz O2, Gonzalez-Sanchez E3, Perez MJ4, Ghanem CI5, Marin JJ6.Author information 1Laboratory of Experimental Hepatology and Drug Targeting (HEVEFARM), IBSAL, University of Salamanca, Salamanca, Spain; CIBERehd, Instituto de Salud Carlos III, Madrid, Spain. Electronic address: albamgb@usal.es.2Laboratory of Experimental Hepatology and Drug Targeting (HEVEFARM), IBSAL, University of Salamanca, Salamanca, Spain; CIBERehd, Instituto de Salud Carlos III, Madrid, Spain. Electronic address: obriz@usal.es.3Laboratory of Experimental Hepatology and Drug Targeting (HEVEFARM), IBSAL, University of Salamanca, Salamanca, Spain. Electronic address: u60343@usal.es.4Laboratory of Experimental Hepatology and Drug Targeting (HEVEFARM), IBSAL, University of Salamanca, Salamanca, Spain; University Hospital of Salamanca, IECSCYL-IBSAL, Salamanca, Spain; CIBERehd, Instituto de Salud Carlos III, Madrid, Spain. Electronic address: mjperez@usal.es.5Instituto de Investigaciones Farmacologicas, Facultad de Farmacia y Bioquimica, CONICET, Universidad de Buenos Aires, Buenos Aires, Argentina. Electronic address: cghanem@ffyb.uba.ar.6Laboratory of Experimental Hepatology and Drug Targeting (HEVEFARM), IBSAL, University of Salamanca, Salamanca, Spain; CIBERehd, Instituto de Salud Carlos III, Madrid, Spain. Electronic address: jjgmarin@usal.es.AbstractAcetaminophen is used as first-choice drug for pain relief during pregnancy. Here we have investigated the effect of acetaminophen at subtoxic doses on the expression of ABC export pumps in trophoblast cells and its functional repercussion on the placental barrier during maternal cholestasis. The incubation of human choriocarcinoma cells (JAr, JEG-3 and BeWo) with acetaminophen for 48h resulted in no significant changes in the expression and/or activity of MDR1 and MRPs. In contrast, in JEG-3 cells, BCRP mRNA, protein, and transport activity were reduced. In rat placenta, collected at term, acetaminophen administration for the last three days of pregnancy resulted in enhanced mRNA, but not protein, levels of Mrp1 and Bcrp. In fact, a decrease in Bcrp protein was found. Using in situ perfused rat placenta, a reduction in the Bcrp-dependent fetal-to-maternal bile acid transport after treating the dams with acetaminophen was found. Complete biliary obstruction in pregnant rats induced a significant bile acid accumulation in fetal serum and tissues, which was further enhanced when the mothers were treated with acetaminophen. This drug induced increased ROS production in JEG-3 cells and decreased the total glutathione content in rat placenta. Moreover, the NRF2 pathway was activated in JEG-3 cells as shown by an increase in nuclear NRF2 levels and an up-regulation of NRF2 target genes, NQO1 and HMOX-1, which was not observed in rat placenta. In conclusion, acetaminophen induces in placenta oxidative stress and a down-regulation of BCRP/Bcrp, which may impair the placental barrier to bile acids during maternal cholestasis.
  • Toxicology and applied pharmacology.Toxicol Appl Pharmacol.2014 May 15;277(1):77-85. doi: 10.1016/j.taap.2014.02.019. Epub 2014 Mar 11.
  • Acetaminophen is used as first-choice drug for pain relief during pregnancy. Here we have investigated the effect of acetaminophen at subtoxic doses on the expression of ABC export pumps in trophoblast cells and its functional repercussion on the placental barrier during maternal cholestasis. The in
  • PMID 24631341

和文文献

  • Single-step simultaneous side-by-side placement of a self-expandable metallic stent with a 6-Fr delivery system for unresectable malignant hilar biliary obstruction : a feasibility study
  • Kawakubo Kazumichi,Kawakami Hiroshi,Kuwatani Masaki [他]
  • Journal of hepato-biliary
  • NAID 40020363680
  • Arterial blood gas anomaly in canine hepatobiliary disease
  • KANEKO Yasuyuki,TORISU Shidow,KOBAYASHI Takumi,MIZUTANI Shinya,TSUZUKI Nao,SONODA Hiroko,IKEDA Masahiro,NAGANOBU Kiyokazu
  • Journal of Veterinary Medical Science advpub(0), 2015
  • … Although pulmonary complications of liver disease have not been reported in dogs, we have frequently encountered hypoxemia in dogs with liver disorders, especially extrahepatic biliary obstruction. … By classifying type of hepatobiliary disease, dogs with extrahepatic biliary obstruction and chronic hepatitis showed significantly lower PaO2 and higher AaDO2 than in a control group. …
  • NAID 130005091936

関連リンク

Biliary obstruction Images Digestive system Endocrine glands Bile pathway Biliary obstruction - series References Afdhal NH. Diseases of the gallbladder and bile ducts. In: Goldman L, Schafer AI, eds.Goldman's Cecil Medicine ...
Gallstone disease is the most common cause of biliary obstruction. Women are much more likely to develop gallstones than men. By the sixth decade, almost 25% of American women develop gallstones, with as many ...

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★リンクテーブル★
リンク元胆管閉塞症」「胆道閉塞」「胆道閉塞症」「bile duct obstruction
拡張検索extrahepatic biliary obstruction
関連記事obstruction」「biliary

胆管閉塞症」

  [★]

biliary obstructionbile duct obstruction
胆道閉塞胆管閉塞胆道閉塞症


胆道閉塞」

  [★]

biliary obstruction
胆管閉塞症胆管閉塞胆道閉塞症


胆道閉塞症」

  [★]

biliary obstruction
胆管閉塞症胆道閉塞胆管閉塞


bile duct obstruction」

  [★]

胆管閉塞症胆管閉塞

biliary obstructioncholestasis


extrahepatic biliary obstruction」

  [★]

肝外胆管閉塞

extrahepatic bile duct obstruction


obstruction」

  [★]

  • n.
  • 妨害、障害、支障、差し障り。妨害物、
  • 閉塞閉塞症
blockagedeterrentobliterationoccludeocclusionstasis

WordNet   license wordnet

「any structure that makes progress difficult」
obstructor, obstructer, impediment, impedimenta

WordNet   license wordnet

「getting in someone''s way」

WordNet   license wordnet

「the act of obstructing; "obstruction of justice"」

WordNet   license wordnet

「the physical condition of blocking or filling a passage with an obstruction」
blockage

PrepTutorEJDIC   license prepejdic

「〈U〉(…への)妨害,障害《+『to』+『名』》 / 〈C〉(…への)妨害物,障害物《+『to』+『名』》」


biliary」

  [★]

  • adj.
  • 胆汁の
bilecholicgall

WordNet   license wordnet

「relating to the bile ducts or the gallbladder」




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