胆汁酸代謝
WordNet
- street name for lysergic acid diethylamide (同)back breaker, battery-acid, dose, dot, Elvis, loony toons, Lucy in the sky with diamonds, pane, superman, window pane, Zen
- any of various water-soluble compounds having a sour taste and capable of turning litmus red and reacting with a base to form a salt
- having the characteristics of an acid; "an acid reaction"
- a digestive juice secreted by the liver and stored in the gallbladder; aids in the digestion of fats (同)gall
- the organic processes (in a cell or organism) that are necessary for life (同)metabolic_process
PrepTutorEJDIC
- 酸性の / 酸味のある,すっぱい(sour) / (言葉・態度などが)厳しい,しんらつな / 酸 / すっぱいもの / 《俗》=LSD
- 胆汁(たんじゅう) / かんしゃく;不きげん
- 新陳代謝,物質交代
UpToDate Contents
全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.
English Journal
- Obesity and NAFLD: The Role of Bacteria and Microbiota.
- Duseja A, Chawla YK.Author information Department of Hepatology, Post Graduate Institute of Medical Education and Research, Sector 12, Chandigarh 160012, India.AbstractThere are trillions of microorganisms in the human intestine collectively called gut microbiota. Obesity may be affected by the gut microbiota through energy harvesting and fat storage by the bacteria. Small intestinal bacterial overgrowth is also responsible for endotoxemia, systemic inflammation, and its consequences including obesity and nonalcoholic fatty liver disease (NAFLD). Relationship between gut microbiota and NAFLD is also dependent on altered choline and bile acid metabolism and endogenous alcohol production by gut bacteria. Further evidence linking gut microbiota with obesity and NAFLD comes from studies showing usefulness of probiotics in animals and patients with NAFLD. This article reviews the relationship among gut microbiota, obesity, and NAFLD.
- Clinics in liver disease.Clin Liver Dis.2014 Feb;18(1):59-71. doi: 10.1016/j.cld.2013.09.002. Epub 2013 Oct 24.
- There are trillions of microorganisms in the human intestine collectively called gut microbiota. Obesity may be affected by the gut microbiota through energy harvesting and fat storage by the bacteria. Small intestinal bacterial overgrowth is also responsible for endotoxemia, systemic inflammation,
- PMID 24274865
- Activation of farnesoid X receptor induces RECK expression in mouse liver.
- Peng X1, Wu W2, Zhu B1, Sun Z1, Ji L1, Ruan Y1, Zhou M3, Zhou L4, Gu J2.Author information 1Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China.2Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China; Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, China.3Department of Radiology, Zhongshan Hospital of Fudan University and Shanghai Institute of Medical Imaging, Shanghai 200032, China. Electronic address: meilingzhou2012@gmail.com.4Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China. Electronic address: yhchloech@gmail.com.AbstractFarnesoid X receptor (FXR) belongs to the ligand-activated nuclear receptor superfamily, and functions as a transcription factor regulating the transcription of numerous genes involved in bile acid homeostasis, lipoprotein and glucose metabolism. In the present study, we identified RECK, a membrane-anchored inhibitor of matrix metalloproteinases, as a novel target gene of FXR in mouse liver. We found that FXR agonist substantially augmented hepatic RECK mRNA and protein expression in vivo and in vitro. FXR regulated the transcription of RECK through directly binding to FXR response element located within intron 1 of the mouse RECK gene. Moreover, FXR agonist reversed the down-regulation of RECK in the livers from mice fed a methionine and choline deficient diet. In summary, our data suggest that RECK is a novel transcriptional target of FXR in mouse liver, and provide clues to better understanding the function of FXR in liver.
- Biochemical and biophysical research communications.Biochem Biophys Res Commun.2014 Jan 3;443(1):211-6. doi: 10.1016/j.bbrc.2013.11.082. Epub 2013 Nov 28.
- Farnesoid X receptor (FXR) belongs to the ligand-activated nuclear receptor superfamily, and functions as a transcription factor regulating the transcription of numerous genes involved in bile acid homeostasis, lipoprotein and glucose metabolism. In the present study, we identified RECK, a membrane-
- PMID 24291500
- Alpha-naphthylisothiocyanate modulates hepatobiliary transporters in sandwich-cultured rat hepatocytes.
- Guo C, He L, Yao D, A J, Cao B, Ren J, Wang G, Pan G.Author information Center for Drug Safety Evaluation & Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China; Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing 210009, Jiangsu, China.AbstractAlpha-naphthylisothiocyanate (ANIT) induces intra-hepatic cholestasis mixed with hepatocellular injury mainly by bile ductular damage. However, its direct effect on hepatic parenchymal cells (hepatocytes) is unclear. Sandwich-cultured rat hepatocytes (SCRH) were applied to clarify this question. Though cytotoxicity was not observed (0-180μM) in ANIT-treated SCRH, metabonomics analysis of the hepatocytes revealed a shift in the metabolic pattern and a decrease in cellular cholesterol level, accompanied by an increase in total bile acids after 48h ANIT (5-45μM) treatment. To assess the function of major hepatic bile acid transporters, the accumulation and efflux of [D-Pen(2,5)]-enkephalin (DPDPE), 5 (and 6)-carboxy-2',7'-dichlorofluorescein (CDF) diacetate promoiety and deuterium-labeled sodium taurocholate (d8-TCA) were measured. ANIT incubation for either 30min or 48h led to dose-dependent decreases in the biliary excretion index (BEI) of DPDPE and CDF, as well as the intracellular accumulation of d8-TCA, CDF and DPDPE. The basolateral efflux of d8-TCA was also decreased with its BEI barely changed. mRNA expression of multiple uptake transporters and bile acid synthesizing enzymes was down-regulated after 48h incubation. In conclusion, ANIT could directly induce retention of bile acids in hepatocytes by inhibiting the function of bile acid transporters, which might contribute to its cholestatic effect.
- Toxicology letters.Toxicol Lett.2014 Jan 3;224(1):93-100. doi: 10.1016/j.toxlet.2013.09.019. Epub 2013 Oct 9.
- Alpha-naphthylisothiocyanate (ANIT) induces intra-hepatic cholestasis mixed with hepatocellular injury mainly by bile ductular damage. However, its direct effect on hepatic parenchymal cells (hepatocytes) is unclear. Sandwich-cultured rat hepatocytes (SCRH) were applied to clarify this question. Tho
- PMID 24120425
Japanese Journal
- 胆汁酸の受容体と代謝制御 (特集 栄養素の受容・情報伝達と代謝制御)
- Anti-diabetic Effects of Adlay Protein in Type 2 Diabetic db/db Mice
- WATANABE Mitsuru,KATO Masako,AYUGASE Jun
- Food Science and Technology Research 18(3), 383-390, 2012
- … We examined the effects of adlay protein concentrates (AP) on lipid metabolism and on in vivo oxidative stress in type 2 diabetic db/db mice. … Plasma parameters, such as total cholesterol, arteriosclerotic index and thiobarbituric acid reactive substances (TBARS) concentration in the diabetic AP-fed group were lower than those in the diabetic control (AIN-93G) group. … A pronounced improvement in lipid metabolism of the AP-fed group was observed when compared with the AG-fed group. …
- NAID 130001922867
Related Links
- Bile acid homeostasis in T2D Due to their long-known role in the digestion of dietary fat, bile acids have classically been associated with lipid metabolism. Over the past decades, a limited number of studies has described alterations ...
- Chiang JYL. Regulation of bile acid synthesis. Front Biosci. 1998;3:D176–93. Russell DW. The enzymes, regulation, and genetics of bile acid synthesis. Annu Rev Biochem. 2003;72:137–74. CrossRef Chiang JY. Regulation of bile ...