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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/01/08 06:38:21」(JST)

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Bifemelane (Alnert, Celeport) is a pharmaceutical drug used in the treatment of senile dementia in Japan.^[1] It has nootropic, neuroprotective, and antidepressant effects, and acts through the cholinergic system in the brain.^[2]^[3]^[4] Bifemelane is also useful for the treatment of glaucoma.^[5]

References

^ David J. Triggle (1996). Dictionary of Pharmacological Agents. Boca Raton: Chapman & Hall/CRC. p. 265. ISBN 0-412-46630-9.
^ Kondo, Y; Ogawa, N; Asanuma, M; Matsuura, K; Nishibayashi, K; Iwata, E (1996). "Preventive effects of bifemelane hydrochloride on decreased levels of muscarinic acetylcholine receptor and its mRNA in a rat model of chronic cerebral hypoperfusion". Neuroscience research 24 (4): 409–14. doi:10.1016/0168-0102(95)01017-3. PMID 8861111.
^ Egashira, T; Takayama, F; Yamanaka, Y (1996). "Effects of bifemelane on muscarinic receptors and choline acetyltransferase in the brains of aged rats following chronic cerebral hypoperfusion induced by permanent occlusion of bilateral carotid arteries". Japanese journal of pharmacology 72 (1): 57–65. doi:10.1254/jjp.72.57. PMID 8902600.
^ Moryl E, Danysz W, Quack G (June 1993). "Potential antidepressive properties of amantadine, memantine and bifemelane". Pharmacology & Toxicology 72 (6): 394–7. doi:10.1111/j.1600-0773.1993.tb01351.x. PMID 8361950.
^ Shigemitsu, T; Majima, Y (1996). "Use of bifemelane hydrochloride in improving and maintaining the visual field of patients with glaucoma". Clinical therapeutics 18 (1): 106–13. doi:10.1016/S0149-2918(96)80183-4. PMID 8851457.

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English Journal

Effects of bifemelane on the calcium level and ATP release of the human origin astrocyte clonal cell.

Yoshida Y1, Kumagai H, Ohkubo Y, Tsuchiya R, Morita M, Miyakawa H, Kudo Y.
Journal of pharmacological sciences.J Pharmacol Sci.2006 Sep;102(1):121-8. Epub 2006 Sep 15.
The effect of bifemelane hydrochloride (bifemelane) was examined on human origin astrocyte clonal cells (Kings-1). Bifemelane (125 - 1,000 microM) induced a dose-dependent increase in the intracellular calcium concentration ([Ca(2+)](i)). In the highest concentration (1,000 microM), the drug caused
PMID 16974067

A novel effect of bifemelane, a nootropic drug, on intracellular Ca2+ levels in rat cerebral astrocytes.

Yoshida Y1, Nakane A, Morita M, Kudo Y.
Journal of pharmacological sciences.J Pharmacol Sci.2006 Feb;100(2):126-32. Epub 2006 Feb 11.
We investigated the effects of bifemelane, a nootropic drug, on the intracellular calcium concentration ([Ca2+]i) in rat cerebral astrocytes using a Ca2+ imaging device. At concentrations of 10 - 30 microM, bifemelane induced a slow onset and small increase in the [Ca2+]i, while at higher concentrat
PMID 16474207

Involvement of cholinergic and GABAergic systems in the reversal of memory disruption by NS-105, a cognition enhancer.

Ogasawara T1, Itoh Y, Tamura M, Mushiroi T, Ukai Y, Kise M, Kimura K.
Pharmacology, biochemistry, and behavior.Pharmacol Biochem Behav.1999 Sep;64(1):41-52.
The effects of (+)-5-oxo-D-prolinepiperidinamide monohydrate (NS-105) on the scopolamine-, electrolytic lesion of the nucleus basalis magnocellularis (NBM)-, AF64A-, baclofen-, cerebral ischemia- and electroconvulsive shock (ECS)-induced memory disruption in the passive avoidance response or radial
PMID 10494996

Japanese Journal

Effects of Bifemelane on the Calcium Level and ATP Release of the Human Origin Astrocyte Clonal Cell

YOSHIDA Yoshitoku,KUMAGAI Haruno,OHKUBO Yoshiumi,TSUCHIYA Remi,MORITA Mitsuhiro,MIYAKAWA Hiroyoshi,KUDO Yoshihisa
Journal of pharmacological sciences 102(1), 121-128, 2006-09-20
… The effect of bifemelane hydrochloride (bifemelane) was examined on human origin astrocyte clonal cells (Kings-1). … Bifemelane (125 – … Bifemelane caused a dose-dependent ATP release, but histamine and carbachol, which induced a large increase in [Ca2+]i, had no effects on the ATP release. …
NAID 10020346475

A Novel Effect of Bifemelane, a Nootropic Drug, on Intracellular Ca^<2+> Levels in Rat Cerebral Astrocytes

YOSHIDA Yoshitoku,NAKANE Akira,MORITA Mitsuhiro,KUDO Yoshihisa
Journal of pharmacological sciences 100(2), 126-132, 2006-02-20
… We investigated the effects of bifemelane, a nootropic drug, on the intracellular calcium concentration ([Ca2+]i) in rat cerebral astrocytes using a Ca2+ imaging device. … 30 μM, bifemelane induced a slow onset and small increase in the [Ca2+]i, while at higher concentrations (100 – … When thapsigargin-treated astrocytes were returned to normal medium containing Ca2+ (1.8 mM), the [Ca2+]i increased significantly, and this effect was reversely inhibited by bifemelane. …
NAID 10018240701

Related Pictures

★リンクテーブル★

リンク元	「ビフェメラン」
拡張検索	「bifemelane hydrochloride」

「ビフェメラン」

Bifemelane
Systematic (IUPAC) name
	N-methyl-4-[2-(phenylmethyl)phenoxy]butan-1-amine
Clinical data
AHFS/Drugs.com	International Drug Names
Legal status	?
Identifiers
CAS number	90293-01-9
ATC code	N06AX08
PubChem	CID 2377
ChemSpider	2286
UNII	Z4501GN13G
ChEMBL	CHEMBL1192517
Chemical data
Formula	C18H23NO
Molecular mass	269.381 g/mol
	SMILES O(c1ccccc1Cc2ccccc2)CCCCNC;
	InChI InChI=1S/C18H23NO/c1-19-13-7-8-14-20-18-12-6-5-11-17(18)15-16-9-3-2-4-10-16/h2-6,9-12,19H,7-8,13-15H2,1H3 ; Key:QSQQPMHPCBLLGX-UHFFFAOYSA-N ;
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