English Journal

Internal Ribosome Entry Site-Based Bicistronic In Situ Reporter Assays for Discovery of Transcription-Targeted Lead Compounds.

Lang L1, Ding HF2, Chen X3, Sun SY4, Liu G5, Yan C6.
Chemistry & biology.Chem Biol.2015 Jul 23;22(7):957-64. doi: 10.1016/j.chembiol.2015.06.009. Epub 2015 Jul 2.
Although transgene-based reporter gene assays have been used to discover small molecules targeting expression of cancer-driving genes, the success is limited due to the fact that reporter gene expression regulated by incomplete cis-acting elements and foreign epigenetic environments does not faithfu
PMID 26144883

A recombinant adenovirus bicistronically expressing porcine interferon-α and interferon-γ enhances antiviral effects against foot-and-mouth disease virus.

Kim SM1, Kim SK2, Park JH2, Lee KN2, Ko YJ2, Lee HS2, Seo MG2, Shin YK2, Kim B2.
Antiviral research.Antiviral Res.2014 Apr;104:52-8. doi: 10.1016/j.antiviral.2014.01.014. Epub 2014 Jan 29.
Foot-and-mouth disease (FMD) is a virulent and economically costly disease in domestic livestock. Since the current vaccine available against FMD provides no protection until 7days postvaccination, the only alternative method to halt the spread of the FMD virus (FMDV) during outbreaks is by the appl
PMID 24485895

Heterologous production and functional and thermodynamic characterization of cation diffusion facilitator (CDF) transporters of mesophilic and hyperthermophilic origin.

Goswami D1, Kaur J, Surade S, Grell E, Michel H.
Biological chemistry.Biol Chem.2012 Jul;393(7):617-29. doi: 10.1515/hsz-2012-0101.
The members of the cation diffusion facilitator (CDF) family transport heavy metal ions and play an important function in zinc ion homeostasis of the cell. A recent structure of an Escherichia coli CDF transporter protein YiiP has revealed its dimeric nature and autoregulatory zinc transport mechani
PMID 22944666