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  • Preparation, in vitro and in vivo evaluation of bexarotene nanocrystals with surface modification by folate-chitosan conjugates.
  • Li L1, Liu Y, Wang J, Chen L, Zhang W, Yan X.
  • Drug delivery.Drug Deliv.2014 Apr 30. [Epub ahead of print]
  • Abstract Bexarotene (Bex) is a synthetic retinoid that exhibits anti-tumor activities. However, the low solubility of the compound hinders its development. In this study, bexarotene nanocrystal was developed and its surface was modified to improve the dissolution and absorption of the drug. The nano
  • PMID 24786485
  • Protective Effects of Bexarotene against Amyloid-β25-35-Induced Dysfunction in Hippocampal Neurons through the Insulin Signaling Pathway.
  • Dai W1, Yang J, Chen T, Yang Z.
  • Neuro-degenerative diseases.Neurodegener Dis.2014 Apr 30. [Epub ahead of print]
  • Background: Bexarotene, a retinoid X receptor agonist, has been shown to reverse neurodegeneration in mouse models of Alzheimer's disease (AD), accompanied by a decreased level of amyloid-β (Aβ), which is a hallmark of AD. However, the mechanism underlying this therapeutic effect may involve enhan
  • PMID 24802415
  • Retinoic Acid Isomers Facilitate Apolipoprotein E Production and Lipidation in Astrocytes through the Retinoid X Receptor/Retinoic Acid Receptor Pathway.
  • Zhao J1, Fu Y, Liu CC, Shinohara M, Nielsen HM, Dong Q, Kanekiyo T, Bu G.
  • The Journal of biological chemistry.J Biol Chem.2014 Apr 18;289(16):11282-92. doi: 10.1074/jbc.M113.526095. Epub 2014 Mar 5.
  • Apolipoprotein E (apoE) is the major cholesterol transport protein in the brain. Among the three human APOE alleles (APOE2, APOE3, and APOE4), APOE4 is the strongest genetic risk factor for late-onset Alzheimer disease (AD). The accumulation of amyloid-β (Aβ) is a central event in AD pathogenesis.
  • PMID 24599963


  • 中枢性甲状腺機能低下症の病能生理に関連するメカニズムと管理
  • Yamada Masanobu,Mori Masatomo
  • Nature clinical practice, Endocrinology & metabolism 1(4), 156-166, 2009-03
  • NAID 40016543944
  • 皮膚T細胞リンパ腫 : 難治例の内科的治療と新規薬剤の展望 (特集 悪性リンパ腫 : 臨床で遭遇する問題とその対応指針)


宇都宮徳一郎、以下「ミノファーゲン製薬」)は、皮膚T細胞リンパ腫治療剤「bexarotene(一般名)」に関して、このたび日本におけるライセンス契約を締結しました。 今回の契約締結により、エーザイはミノファーゲン製薬 に対し ...
Before taking bexarotene, tell your doctor and pharmacist if you are allergic to bexarotene; or any other retinoid, such as acitretin (Soriatane), etretinate (Tegison), isotretinoin (Accutane), or tretinoin (Vesanoid); or any ...


对bexarotene或该产品的其他成分 Bexarotene synthesis: Ligand Return to main pageBexarotene Chemical StructureBEXAROTENE EN ALZHEIMERbexarotene review buy bexarotene




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