beta-2 adrenoceptor

出典: meddic

beta-2 adrenergic receptorbeta-2 receptor、beta2 adrenergic receptor、beta2 adrenoceptor、beta2 receptor

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英文文献

  • β(2)-Adrenoceptor and insulin receptor expression in the skeletal muscle of streptozotocin induced diabetic rats: Antagonism by vitamin D(3) and curcumin.
  • Xavier S, Sadanandan J, George N, Paulose CS.AbstractDiabetes mellitus is a heterogeneous disease and nutritional therapy forms a necessary dimension for its long-term management. Traditional medicinal plants and vitamins are the potentially useful natural products for diabetes control. Diabetes causes atrophy and wasting of skeletal muscles resulting in major peripheral damage. The current study was designed to investigate the therapeutic effect of vitamin D(3) and curcumin treatment on β(2)-adrenoceptors, transcription factor CREB, insulin receptors, protein kinase B (Akt) and malate dehydrogenase activity in the skeletal muscle of diabetic rats. Radioreceptor binding assay was done for β(2)-adrenoceptors using specific ligand, [(3)H] propranolol and gene expression studies of β(2)-adrenoceptors, transcription factor CREB, insulin receptors and Akt were also done using specific probes. The results of the β(2)-adrenoceptor assay showed significant increase in binding parameters, receptor number (B(max)) and equilibrium dissociation constant (K(d)) in the diabetic group in comparison to control. Similarly, an up regulation of β(2)-adrenoceptor and CREB gene expression was observed in the diabetic group whereas the insulin receptor expression was down regulated which signifies the increased glycogenolysis, gluconeogenesis and decreased glycogenesis in the muscles. Expression of Akt was found to be up regulated in the diabetic group. Malate dehydrogenase activity was significantly decreased in both cytosolic and mitochondrial fractions of the diabetic group. All these molecular aspects were reversed to near control with vitamin D(3) and curcumin treatment. Our results suggest the rising potential of both vitamin D(3) and curcumin in the management of peripheral complications associated with diabetes.
  • European journal of pharmacology.Eur J Pharmacol.2012 Jul 15;687(1-3):14-20. Epub 2012 May 10.
  • Diabetes mellitus is a heterogeneous disease and nutritional therapy forms a necessary dimension for its long-term management. Traditional medicinal plants and vitamins are the potentially useful natural products for diabetes control. Diabetes causes atrophy and wasting of skeletal muscles resulting
  • PMID 22579915
  • β(2) long-acting and anticholinergic drugs control TGF-β1-mediated neutrophilic inflammation in COPD.
  • Profita M, Bonanno A, Montalbano AM, Albano GD, Riccobono L, Siena L, Ferraro M, Casarosa P, Pieper MP, Gjomarkaj M.SourceUnit: "Ex vivo/In vitro models to study the Immunopathology and the Pharmacology of airway diseases", Institute of Biomedicine and Molecular Immunology (IBIM), Italian National Research Council (CNR), Palermo, Italy.
  • Biochimica et biophysica acta.Biochim Biophys Acta.2012 Jul;1822(7):1079-89. Epub 2012 Mar 13.
  • We quantified TGF-β1 and acetylcholine (ACh) concentrations in induced sputum supernatants (ISSs) from 18 healthy controls (HC), 22 healthy smokers (HS) and 21 COPDs. ISSs from HC, HS and COPD as well as rhTGF-β1 were also tested in neutrophil adhesion and in mAChR2, mAChR3 and ChAT expression exp
  • PMID 22440430

和文文献

  • Pharmacogenetics of .BETA.2-Agonists
  • Allergology International 60(3), 239-246, 2011
  • … Short-acting β2-agonists (SABAs) and long-acting β2-agonists (LABAs) are both important for treatment of asthma and chronic obstructive pulmonary disease (COPD) because of their bronchodilator and bronchoprotective effects. … Variation in response to both SABAs and LABAs has been observed in patients with polymorphisms in the β2 adrenoceptor gene (ADRB2). …
  • NAID 130004723033
  • Down-regulation of histamine H-1 receptors by beta(2)-adrenoceptor-mediated inhibition of H-1 receptor gene transcription
  • Miyoshi Katsuhiro,Kawakami Nozomi,Umehara Hayato,Fujimoto Katsumi,Horio Shuhei,Fukui Hiroyuki
  • JOURNAL OF PHARMACY AND PHARMACOLOGY 60(6), 747-752, 2008
  • NAID 120004665001
  • Association of beta-2-adrenoceptor polymorphisms and pulmonary function in patients with chronic obstructive pulmonary disease
  • RUSE Charlotte E,HILL Maureen C,WHEATLEY Amanda P,BURTON Paul B,CONNOLLY Martin J,PARKER Stuart G,WARDLAW Andrew J
  • Geriatrics & gerontology international 6(2), 129-135, 2006-06-01
  • NAID 10017616331

関連リンク

Beta-2 adrenoceptors are activated by the catecholamines norepinephrine and epinephrine, and are members of the adrenoceptor family of the 7-transmembrane super ... Localization Protein Beta-2 adrenoceptors are found in many ...
InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites. We combine protein signatures from a number of member databases into a single searchable resource ...

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★リンクテーブル★
リンク元beta-2 adrenergic receptor」「beta-2 receptor」「β2アドレノセプター
関連記事be」「bet」「beta」「adrenoceptor」「Beta

beta-2 adrenergic receptor」

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adrenergic beta-2 receptorbeta-2 adrenoceptorbeta-2 receptor、beta2 adrenergic receptor、beta2 adrenoceptor、beta2 receptor


beta-2 receptor」

  [★]

β2受容体β2レセプターβ2アドレナリン受容体

beta-2 adrenergic receptorbeta-2 adrenoceptor、beta2 adrenergic receptor、beta2 adrenoceptor、beta2 receptor


β2アドレノセプター」

  [★]

beta2 adrenoceptor、beta-2 adrenoceptor
β2アドレナリン受容体


be」

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WordNet   license wordnet

「to remain unmolested, undisturbed, or uninterrupted -- used only in infinitive form; "let her be"」

PrepTutorEJDIC   license prepejdic

「《連結語として補語を伴なって…『である』,…だ,…です / 《位置・場所を表す語句を伴って》(…に)『ある』,いる(occupy a place or situation) / 〈物事が〉『存在する』,ある(exist);〈生物が〉生存する,生きている(live) / 行われる,起こる,発生する(take place, occur) / 存続する,そのままでいる(remain as before) / 《『be to』 do》 / …する予定である,…することになっている / …すべきだ / 《受動態の不定詞を伴って》…できる / 《命令》…するのだ / 《条件節に》…する意図がある / 《『if…were to』 do》…するとしたなら / 《『be』 do『ing』》《進行形》 / 《進行中の動作》…している,しつつある / 《近い未来》…しようとしている,するつもり / 《動作の反復》(いつも)…している / 《『be』+『他動詞の過去分詞』》《受動態》…される,されている / 《『be』+『自動詞の過去分詞』》《完了形》…した[状態にある]」

WordNet   license wordnet

「work in a specific place, with a specific subject, or in a specific function; "He is a herpetologist"; "She is our resident philosopher"」
follow

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「have life, be alive; "Our great leader is no more"; "My grandfather lived until the end of war"」
live

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「be identical to; be someone or something; "The president of the company is John Smith"; "This is my house"」

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「happen, occur, take place; "I lost my wallet; this was during the visit to my parents'' house"; "There were two hundred people at his funeral"; "There was a lot of noise in the kitchen"」

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「have the quality of being; (copula, used with an adjective or a predicate noun); "John is rich"; "This is not a good answer"」

WordNet   license wordnet

「occupy a certain position or area; be somewhere; "Where is my umbrella?" "The toolshed is in the back"; "What is behind this behavior?"」

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「spend or use time; "I may be an hour"」


bet」

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WordNet   license wordnet

「stake on the outcome of an issue; "I bet $100 on that new horse"; "She played all her money on the dark horse"」
wager, play

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「the act of gambling; "he did it on a bet"」
wager

PrepTutorEJDIC   license prepejdic

「『かけ』・(…との)かけ《+『with』+『名』》 / かけた物(金) / かけの対象 / 〈金・物〉'を'『かける』 / (かけ事・ゲームなどで)〈人〉‘と'『かけをする』《+『名』〈人〉+『on』+『名』》 / (…に)『かける』《+『on』(『against』)+『名』(one's do『ing』)》」

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「maintain with or as if with a bet; "I bet she will be there!"」
wager


beta」

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βベータ

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「second in order of importance; "the candidate, considered a beta male, was perceived to be unable to lead his party to victory"」

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「the 2nd letter of the Greek alphabet」

PrepTutorEJDIC   license prepejdic

「ベータ(ギリシア語アルファベットの第2文字;B,β;英語のB,b に遭当)」

WordNet   license wordnet

「preliminary or testing stage of a software or hardware product; "a beta version"; "beta software"」


adrenoceptor」

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adrenergic receptoradrenoreceptor


Beta」

  [★]

WordNet   license wordnet

「beets」
genus Beta




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