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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/04/10 23:50:55」(JST)

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Bepridil (trade name Vascor) is an amine calcium channel blocker once used to treat angina. It is no longer sold in the United States.

It is nonselective.^[1]

It has been discussed as a possible option in the treatment of atrial fibrillation.^[2]

It has been implicated in causing ventricular arrhythmia (torsades de pointes).

Ebola research

In June 2015 a research paper ^[3] was published finding bepridil to result in a 100% survival rate for mice exposed to ebola during an experiment searching for potential pharmaceutical ebola treatments; indicating its potential use in future ebola research and therapy.^[4]

References

^ Bezprozvanny I, Tsien RW (September 1995). "Voltage-dependent blockade of diverse types of voltage-gated Ca2+ channels expressed in Xenopus oocytes by the Ca2+ channel antagonist mibefradil (Ro 40-5967)". Mol. Pharmacol. 48 (3): 540–9. PMID 7565636.
^ Imai S, Saito F, Takase H; et al. (May 2008). "Use of bepridil in combination with Ic antiarrhythmic agent in converting persistent atrial fibrillation to sinus rhythm". Circ. J. 72 (5): 709–15. doi:10.1253/circj.72.709. PMID 18441448.
^ "A screen of approved drugs and molecular probes identifies therapeutics with anti–Ebola virus activity".
^ "Zoloft as Ebola cure? Antidepressant is one of a number of promising drugs being looked at by scientists.".

External links

MedlinePlus DrugInfo medmaster-a697050

This drug article relating to the cardiovascular system is a stub. You can help Wikipedia by expanding it.

UpToDate Contents

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1. 安定狭心症のマネージメントにおけるカルシウム拮抗剤 calcium channel blockers in the management of stable angina pectoris

English Journal

Pharmacological conversion of atrial fibrillation in the patients of graves' disease.

Kunii Y, Uruno T, Matsumoto M, Mukasa K, Noh J, Ito K, Akaishi M, Hori S, Nakazawa H.SourceIto Hospital, Department of Internal Medicine, 4-3-6 Jingumae, Shibuya-ku, Tokyo 150-8308, Japan. y-kidokoro@ito-hospital.jp.
The Tokai journal of experimental and clinical medicine.Tokai J Exp Clin Med.2012 Dec 20;37(4):107-12.
Background: Hyperthyroidism is one of the common causes of atrial fibrillation (AF), and AF is associated with increased morbidity and mortality due to thromboembolism. The sinus rhythm maintenance rate of hyperthyroidism-induced AF patients after conversion to sinus rhythm is excellent. The present
PMID 23238902

Role of the activation gate in determining the extracellular potassium dependency of block of HERG by trapped drugs.

Pareja K, Chu E, Dodyk K, Richter K, Miller A.SourceCollege of Osteopathic Medicine; Touro University California; Vallejo, CA USA.
Channels (Austin, Tex.).Channels (Austin).2012 Dec 6;7(1). [Epub ahead of print]
Drug induced long QT syndrome (diLQTS) results primarily from block of the cardiac potassium channel HERG (human-ether-a-go-go related gene). In some cases long QT syndrome can result in the lethal arrhythmia torsade de pointes, an arrhythmia characterized by a rapid heart rate and severely compromi
PMID 23221912

Japanese Journal

ICD頻回作動時にVisible T-wave Altemansを認めたBrugada症候群の1例

心臓 47(SUPPL.1), S1_145-S1_145, 2015
NAID 130005433980

左室基部後壁起源の心室性期外収縮により心室細動を繰り返した特発性心室細動の1例

心臓 46(SUPPL.2), S2_56-S2_61, 2014
NAID 130005103954

ベプリジルが原因と考えられた薬剤性間質性肺炎の1例

心臓 46(9), 1275-1280, 2014
NAID 130005098812

Related Pictures

★リンクテーブル★

リンク元	「ベプリジル」
拡張検索	「bepridil hydrochloride」

「ベプリジル」

Bepridil
Systematic (IUPAC) name
	N-benzyl-N-(3-isobutoxy-2-pyrrolidin-1-yl-propyl)aniline
Clinical data
Trade names	Vascor
AHFS/Drugs.com	monograph
MedlinePlus	a699051
Pregnancy; category	US: C (Risk not ruled out); ;
Routes of; administration	Oral
Pharmacokinetic data
Bioavailability	Well absorbed
Protein binding	99%
Metabolism	Hepatic, CYP3A4-mediated
Biological half-life	42 hours
Excretion	Renal
Identifiers
CAS Number	64706-54-3
ATC code	C08EA02 (WHO)
PubChem	CID 2351
IUPHAR/BPS	2337
DrugBank	DB01244
ChemSpider	2261
UNII	755BO701MA
ChEBI	CHEBI:3061
ChEMBL	CHEMBL1008
Chemical data
Formula	C24H34N2O
Molar mass	366.54 g/mol
	SMILES O(CC(C)C)CC(N1CCCC1)CN(c2ccccc2)Cc3ccccc3 ;
	InChI InChI=1S/C24H34N2O/c1-21(2)19-27-20-24(25-15-9-10-16-25)18-26(23-13-7-4-8-14-23)17-22-11-5-3-6-12-22/h3-8,11-14,21,24H,9-10,15-20H2,1-2H3 ; Key:UIEATEWHFDRYRU-UHFFFAOYSA-N ;
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　　[★]

英: bepridil
化: 塩酸ベプリジル bepridil hydrochloride
商: ベプリコール
関: 抗不整脈薬

抗不整脈薬;非特異的チャネル遮断;フェニルアルキルアミン系

「bepridil hydrochloride」

　　[★] ベプリジル。塩酸ベプリジル

[pmid7565636-1] Bezprozvanny I, Tsien RW (September 1995). "Voltage-dependent blockade of diverse types of voltage-gated Ca2+ channels expressed in Xenopus oocytes by the Ca2+ channel antagonist mibefradil (Ro 40-5967)". Mol. Pharmacol. 48 (3): 540–9. PMID 7565636.

[pmid18441448-2] Imai S, Saito F, Takase H; et al. (May 2008). "Use of bepridil in combination with Ic antiarrhythmic agent in converting persistent atrial fibrillation to sinus rhythm". Circ. J. 72 (5): 709–15. doi:10.1253/circj.72.709. PMID 18441448.

[3] "A screen of approved drugs and molecular probes identifies therapeutics with anti–Ebola virus activity".

[4] "Zoloft as Ebola cure? Antidepressant is one of a number of promising drugs being looked at by scientists.".

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bepridil