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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/10/20 02:42:53」(JST)

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Bepotastine (Talion) is a 2nd-generation antihistamine.^[1] It was approved in Japan for use in the treatment of allergic rhinitis and urticaria/pruritus in July 2000 and January 2002, respectively, and is marketed by Tanabe Seiyaku Co., Ltd. under the brand name TALION. TALION was co-developed by Tanabe Seiyaku and Ube Industries, Ltd., who discovered bepotastine. In 2001, Tanabe Seiyaku granted Senju exclusive worldwide rights, with the exception of certain Asian countries, to develop, manufacture and market bepotastine for ophthalmic use. Senju, in turn, has granted the United States rights for the ophthalmic preparation to ISTA Pharmaceuticals, Inc., a specialty pharmaceutical company located in Irvine, CA.

References

^ H. Takahashi, A. Ishida-Yamamoto, H. Iizuka (September 2004). "Effects of bepotastine, cetirizine, fexofenadine, and olopatadine on histamine-induced wheal-and flare-response, sedation, and psychomotor performance". Clinical and Experimental Dermatology 29: 526–532. doi:10.1111/j.1365-2230.2004.01618.x.

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English Journal

Effects of Bepotastine and Fexofenadine on Histamine-Induced Flare, Wheal and Itch.

Tanizaki H, Ikoma A, Fukuoka M, Miyachi Y, Kabashima K.SourceDepartment of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
International archives of allergy and immunology.Int Arch Allergy Immunol.2012 Jan 26;158(2):191-195. [Epub ahead of print]
Background: Urticaria is mainly caused by mast cell-derived histamine through the histamine H(1) receptor. Antihistamines are occasionally used on demand upon a recurrence of urticaria; therefore, rapidly acting agents should be explored. The onset of action is assumed to depend on time to maximum c
PMID 22286689

Histamine and H1-antihistamines: celebrating a century of progress.

Simons FE, Simons KJ.SourceDepartment of Pediatrics & Child Health and the Department of Immunology, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada. lmcniven@hsc.mb.ca
The Journal of allergy and clinical immunology.J Allergy Clin Immunol.2011 Dec;128(6):1139-1150.e4. Epub 2011 Oct 27.
In this review we celebrate a century of progress since the initial description of the physiologic and pathologic roles of histamine and 70 years of progress since the introduction of H(1)-antihistamines for clinical use. We discuss histamine and clinically relevant information about the molecular m
PMID 22035879

Japanese Journal

治療ベポタスチンベシル酸塩口腔内崩壊錠の服薬コンプライアンスに与える'医師による味に関する事前説明'の影響

澤田美月,洲崎玲子,石崎純子 [他]
西日本皮膚科 73(4), 402-407, 2011-08-00
NAID 40018942378

そう痒性皮膚疾患におけるベシル酸ベポタスチンの臨床的効果に関するアンケート調査

大森睦美,竹内聡,田代あかり [他],中原剛志,三苫千景,寺尾浩,浦田保志,吉村映里,工藤恭子,安川晋輔,辻田淳,国場尚志,増永可奈,桑原健太郎,市川竜太郎,伊藤絵里子,竹下弘道,安川史子,西江温子,師井洋一,古江増隆
西日本皮膚科 = The Nishinihon journal of dermatology 72(3), 240-245, 2010-06-01
NAID 10026929692

ベポタスチンベシル酸塩のスギ花粉症に対する臨床効果--睡眠に関する検討

菅原一真,原浩貴,御厨剛史 [他]
アレルギ-・免疫 17(4), 654-660, 2010-04-00
NAID 40017030635

「ベポタスチン」

Bepotastine
Systematic (IUPAC) name
	4-[4-[(4-chlorophenyl)-pyridin-2-ylmethoxy]piperidin-1-yl]butanoic acid
Clinical data
AHFS/Drugs.com	International Drug Names
MedlinePlus	a610012
Pregnancy; category	US: C (Risk not ruled out);
Legal status	℞ (Prescription only);
Routes of; administration	Oral, topical (eye drops)
Pharmacokinetic data
Bioavailability	High (oral); Minimal (topical)
Protein binding	~55%
Excretion	Renal (75–90%)
Identifiers
CAS Registry Number	125602-71-3
ATC code	None
PubChem	CID: 2350
DrugBank	DB04890
ChemSpider	2260
UNII	HYD2U48IAS
KEGG	D09705
ChEBI	CHEBI:71204
ChEMBL	CHEMBL1201758
Chemical data
Formula	C21H25ClN2O3
Molecular mass	388.88 g/mol
	SMILES Clc1ccc(cc1)C(OC2CCN(CCCC(=O)O)CC2)c3ncccc3 ;
	InChI InChI=1S/C21H25ClN2O3/c22-17-8-6-16(7-9-17)21(19-4-1-2-12-23-19)27-18-10-14-24(15-11-18)13-3-5-20(25)26/h1-2,4,6-9,12,18,21H,3,5,10-11,13-15H2,(H,25,26) ; Key:YWGDOWXRIALTES-UHFFFAOYSA-N ;
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