benzocaine

出典: meddic

アミノ安息香酸エチルベンゾカイン

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「a white crystalline ester used as a local anesthetic」
ethyl aminobenzoate

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/12/13 22:19:44」(JST)

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英文文献

  • Homology modeling of Kv1.5 channel block by cationic and electroneutral ligands.
  • Tikhonov DB1, Zhorov BS2.Author information 1Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg, Russia. Electronic address: denistikhonov2002@yahoo.com.2Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg, Russia; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.AbstractThe inner pore of potassium channels is targeted by many ligands of intriguingly different chemical structures. Previous studies revealed common and diverse characteristics of action of ligands including cooperativity of ligand binding, voltage- and use-dependencies, and patterns of ligand-sensing residues. Not all these data are rationalized in published models of ligand-channel complexes. Here we have used energy calculations with experimentally defined constraints to dock flecainide, ICAGEN-4, benzocaine, vernakalant, and AVE0118 into the inner pore of Kv1.5 channel. We arrived at ligand-binding models that suggest possible explanations for different values of the Hill coefficient, different voltage dependencies of ligands action, and effects of mutations of residues in subunit interfaces. Two concepts were crucial to build the models. First, the inner-pore block of a potassium channel requires a cationic "blocking particle". A ligand, which lacks a positively charged group, blocks the channel in a complex with a permeant ion. Second, hydrophobic moieties of a flexible ligand have a tendency to bind in hydrophobic subunit interfaces.
  • Biochimica et biophysica acta.Biochim Biophys Acta.2014 Mar;1838(3):978-87. doi: 10.1016/j.bbamem.2013.11.019. Epub 2013 Dec 5.
  • The inner pore of potassium channels is targeted by many ligands of intriguingly different chemical structures. Previous studies revealed common and diverse characteristics of action of ligands including cooperativity of ligand binding, voltage- and use-dependencies, and patterns of ligand-sensing r
  • PMID 24316168
  • Potential diversion of local anesthetics from dental offices for use as cocaine adulterants.
  • Saraghi M1, Hersh EV.Author information 1Dr. Saraghi was an instructor of dental anesthesiology, Department of Periodontics, Division of Pediatric Dentistry, and Department of Oral Surgery and Pharmacology, School of Dental Medicine, University of Pennsylvania, Philadelphia, when this article was written. She now is a dentist anesthesiologist, Northwest Dental Anesthesia, 5528 E. Green Lake Way N., #19, Seattle, Wash. 98103, msaraghi@gmail.com.AbstractBACKGROUND: /st> Reports of lidocaine and benzocaine in the bloodstreams of people who abuse cocaine with accompanying reports of seizures and methemoglobinemia indicate that there is a potential that local anesthetics are being diverted from dental offices and being used as cocaine adulterants. These adulterants augment the nasal numbness produced by inhaling cocaine.
  • Journal of the American Dental Association (1939).J Am Dent Assoc.2014 Mar;145(3):256-9. doi: 10.14219/jada.2013.33.
  • BACKGROUND: /st> Reports of lidocaine and benzocaine in the bloodstreams of people who abuse cocaine with accompanying reports of seizures and methemoglobinemia indicate that there is a potential that local anesthetics are being diverted from dental offices and being used as cocaine adulterants.
  • PMID 24583890
  • Anesthetic efficacy of Oraqix® versus Hurricaine® and placebo for pain control during non-surgical periodontal treatment.
  • Mayor-Subirana G1, Yagüe-García J, Valmaseda-Castellón E, Arnabat-Domínguez J, Berini-Aytés L, Gay-Escoda C.Author information 1Facultat d'Odontologia (UB), Campus de Bellvitge, Pavelló de Govern, Feixa Llarga, s/n, 08907 L'Hospitalet de Llobregat, eduardvalmaseda@ub.edu.AbstractObjectives: To evaluate the efficacy of Oraqix® during scaling and root planing (SRP) in comparison with 20% benzocaine and placebo. Study Design: 15 patients requiring 4 sessions of SRP were enrolled. For each patient, Oraqix®, Hurricaine®, vaseline or no anesthetic product were randomly assigned each to a quadrant. Treatment pain was evaluated on a 100 mm Visual Analog Scale (VAS) and on a Verbal Rating Scale (VRS). The amount of product administered, the need to re-anesthetise, patient and operator satisfaction and the onset of side-effects were also recorded. Results: Oraqix® was significantly better than nothing, with a reduction of VAS score to 13.3 units, but without significant differences with Vaseline or Hurricaine®. Oraqix® was better in VRS reduction than not using any anesthetic (p=0.001) or using vaseline (p=0.024), but similar to Hurricaine® (p=0.232). Conclusions: Oraqix® effectively controls pain in SRP procedures, with few side-effects and a good acceptance on the part of patients and clinicians.
  • Medicina oral, patología oral y cirugía bucal.Med Oral Patol Oral Cir Bucal.2014 Mar 1;19(2):e192-201.
  • Objectives: To evaluate the efficacy of Oraqix® during scaling and root planing (SRP) in comparison with 20% benzocaine and placebo. Study Design: 15 patients requiring 4 sessions of SRP were enrolled. For each patient, Oraqix®, Hurricaine®, vaseline or no anesthetic product were randomly assigne
  • PMID 24316699

和文文献

  • Pain Perception and Anaesthesia in Research Frogs
  • 症例 表面局所麻酔剤ハリケーンゲルの使用によって生じたと考えられるメトヘモグロビン血症の1例
  • アフリカツメガエル卵母細胞に発現したセロトニントランスポーターに対する麻酔薬の作用

関連リンク

Benzocaine is used as a key ingredient in numerous pharmaceuticals: Some glycerol-based ear medications for use in removing excess wax as well as relieving ear conditions such as otitis media and swimmers ear. Some previous ...
Benzocaine is a local anesthetic (numbing medication). It works by blocking nerve signals in your body. Benzocaine topical is used to reduce pain or discomfort caused by minor skin irritations, sore throat, sunburn ...

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ethylaminobenzoate
ethylis aminobenzoas
ベンゾカイン benzocaineパラアミノ安息香酸エチル ethyl p-aminobenzoate
アネスタミン anestamineベンゾカイン benzocaineジンジカインスルカインニチカインネオザロカインパスタ ハリケインヒノポロンビーゾカインプロネスパスタヘルミチンS





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