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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/12/05 21:18:57」(JST)

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Benzamide is an off-white solid with the chemical formula of C₆H₅CONH₂. It is a derivative of benzoic acid. It is slightly soluble in water, and soluble in many organic solvents.

Chemical derivatives[edit]

A number of substituted benzamides exist, including:

Analgesics

Ethenzamide
Salicylamide

Antiemetics/Prokinetics

Alizapride
Bromopride
Cinitapride
Cisapride
Clebopride
Dazopride
Domperidone
Itopride
Metoclopramide
Mosapride
Prucalopride
Renzapride
Trimethobenzamide
Zacopride

Antipsychotics

Amisulpride
Nemonapride
Remoxipride
Sulpiride
Sultopride
Tiapride

Others

Entinostat
Eticlopride
Mocetinostat
Raclopride
Procarbazine

External links[edit]

Physical characteristics
Safety MSDS data
1309016066 at GPnotebook

UpToDate Contents

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English Journal

Computing membrane-AQP5-phosphatidylserine binding affinities with hybrid steered molecular dynamics approach.

Chen LY1.
Molecular membrane biology.Mol Membr Biol.2015 May 8:1-7. [Epub ahead of print]
In order to elucidate how phosphatidylserine (PS6) interacts with AQP5 in a cell membrane, we developed a hybrid steered molecular dynamics (hSMD) method that involved: (1) Simultaneously steering two centers of mass of two selected segments of the ligand, and (2) equilibrating the ligand-protein co
PMID 25955791

PHARMACOLOGICAL CHARACTERIZATION OF THE NEWLY SYNTHESIZED 5-AMINO-N-BUTYL-2-(4-ETHOXYPHENOXY)-BENZAMIDE HYDROCHLORIDE (BED) AS A POTENT NCX3 INHIBITOR THAT WORSENS ANOXIC INJURY IN CORTICAL NEURONS, ORGANOTYPIC HIPPOCAMPAL CULTURES AND ISCHEMIC BRAIN.

Secondo A, Pignataro G, Ambrosino P, Pannaccione A, Molinaro P, Boscia F, Cantile M, Cuomo O, Esposito A, Sisalli M, Scorziello A, Guida N, Anzillotti S, Fiorino F, Severino B, Santagada V, Caliendo G, Di Renzo G, Annunziato L.
ACS chemical neuroscience.ACS Chem Neurosci.2015 May 5. [Epub ahead of print]
The Na+/Ca2+ exchanger (NCX), a 10-transmembrane domain protein mainly involved in the regulation of intracellular Ca2+ homeostasis, plays a crucial role in cerebral ischemia. In the present paper we characterized the effect of the newly synthesized compound 5-Amino-N-butyl-2-(4-ethoxyphenoxy)-benza
PMID 25942323

Sigma-2 receptor binding is decreased in female, but not male, APP/PS1 mice.

Sahlholm K1, Liao F2, Holtzman DM2, Xu J1, Mach RH3.
Biochemical and biophysical research communications.Biochem Biophys Res Commun.2015 May 1;460(2):439-45. doi: 10.1016/j.bbrc.2015.03.052. Epub 2015 Mar 18.
The sigma-2 receptor is a steroid-binding membrane-associated receptor which has been implicated in cell survival. Sigma-2 has recently been shown to bind amyloid-β (Aβ) oligomers in Alzheimer's disease (AD) brain. Furthermore, blocking this interaction was shown to prevent or reverse the effects
PMID 25796326

Japanese Journal

A Novel Inhibitor of I-KappaB Kinase Beta Ameliorates Experimental Arthritis through Downregulation of Proinflammatory Cytokines in Arthritic Joints

Tanaka Shinji,Toki Tadashi,Yokoyama Mika,Shimizu Hiroki,Yamasaki Tomonori,Yoneda Yoshiyuki,Muro Fumihito,Yasukochi Takanori,Iimura Shin,Morishita Kaoru
Biological and Pharmaceutical Bulletin 37(1), 87-95, 2014
… We previously reported a novel IKKβ inhibitor Compound D, 4-[6-(cyclobutylamino)imidazo[1,2-b]pyridazin-3-yl]-2-fluoro-N-{[(2S,4R)-4-fluoropyrrolidin-2-yl]methyl}benzamide, which is efficacious in experimental arthritis models. …
NAID 130003382106

Synthesis and optical properties of poly(p-benzamide)s bearing oligothiophene on the amide nitrogen atom through an alkylene spacer

Takagi Koji,Nobuke Katsuya,Nishikawa Yuma [他]
Polymer journal 45(12), 1171-1176, 2013-12
NAID 40019900318

B305 N-(2-Phenyl-1H-imidazo1-1-yl)benzamide類縁体の合成と脱皮ホルモン受容体に対する結合性の評価(分子設計生物活性遺伝子科学天然物化学,一般講演要旨)

横井大洋,瀧本征佑,中川好秋,宮川恒
講演要旨集 (38), 123, 2013-03-14
NAID 110009761971

Related Pictures

★リンクテーブル★

リンク元	「ベンズアミド」
拡張検索	「trimethobenzamide」「ethoxybenzamide」

「ベンズアミド」

Benzamide
	IUPAC name Benzamide
	Other names Benzoic acid amide, Phenyl carboxamide, Benzoylamide
Identifiers
CAS number	55-21-0
PubChem	2331
ChemSpider	2241
UNII	6X80438640
EC number	200-227-7
KEGG	C09815
ChEBI	CHEBI:28179
ChEMBL	CHEMBL267373
RTECS number	CU8700000
Jmol-3D images	Image 1; Image 2
	SMILES O=C(N)c1ccccc1 c1ccc(cc1)C(=O)N ;
	InChI InChI=1S/C7H7NO/c8-7(9)6-4-2-1-3-5-6/h1-5H,(H2,8,9) ; Key: KXDAEFPNCMNJSK-UHFFFAOYSA-N InChI=1/C7H7NO/c8-7(9)6-4-2-1-3-5-6/h1-5H,(H2,8,9); Key: KXDAEFPNCMNJSK-UHFFFAOYAA ;
Properties
Molecular formula	C7H7NO
Molar mass	121.14 g mol−1
Appearance	Off-white solid
Density	1.341 g/cm3
Melting point	127 - 130 °C
Boiling point	288 °C, 561 K, 550 °F
Solubility in water	13 g/l
Acidity (pKa)	23.35 (in DMSO)
Hazards
EU classification	Harmful (Xn)
R-phrases	R22 R40
S-phrases	S36/37/39
NFPA 704	1 1 0
Flash point	180 °C
Autoignition; temperature	> 500 °C
	(verify) (what is: /?); Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
	Infobox references