関: befunolol hydrochloride

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/09/03 01:10:47」(JST)

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Befunolol (INN) is a beta blocker with intrinsic sympathomimetic activity used in the management of open-angle glaucoma.^[1] It also acts as a β adrenoreceptor partial agonist.^[2]^[3] Befunolol was introduced in Japan in 1983 by Kakenyaku Kako Co. under the trade name Bentos.^[4]

References

^ Stephan Reichl, Christel C Müller-Goymann (2 January 2003). "The use of a porcine organotypic cornea construct for permeation studies from formulations containing befunolol hydrochloride". International Journal of Pharmaceutics. 250 (1): 191–201. doi:10.1016/S0378-5173(02)00541-0.
^ Koike, K; Takayanagi, I (October 1986). "A beta-adrenergic partial agonist (befunolol) discriminates two different affinity sites". Japanese Journal of Pharmacology. 42 (2): 325–8. doi:10.1254/jjp.42.325. PMID 2879061.
^ Takayanagi, I; Koike, K (January 1985). "A beta-adrenoceptor blocking agent, befunolol as a partial agonist in isolated organs". General Pharmacology: The Vascular System. 16 (3): 265–267. doi:10.1016/0306-3623(85)90080-1.
^ Pharmaceutical Manufacturing Encyclopedia (3rd revised ed.). Norwich, N.Y.: William Andrew Publishing. January 14, 2008. p. 542. ISBN 978-0815515265.

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English Journal

Cloning and characterization of four rabbit aldo-keto reductases featuring broad substrate specificity for xenobiotic and endogenous carbonyl compounds: relationship with multiple forms of drug ketone reductases.

Endo S1, Matsunaga T, Arai Y, Ikari A, Tajima K, El-Kabbani O, Yamano S, Hara A, Kitade Y.
Drug metabolism and disposition: the biological fate of chemicals.Drug Metab Dispos.2014 Apr;42(4):803-12. doi: 10.1124/dmd.113.056044. Epub 2014 Feb 7.
Multiple forms of reductases for several drug ketones were isolated from rabbit liver, but their interrelationship and physiologic roles remain unknown. We isolated cDNAs for four aldo-keto reductases (AKR1C30, AKR1C31, AKR1C32, and AKR1C33), which share high amino acid sequence identity with the pa
PMID 24510382

Pharmacological evaluation of ocular beta-adrenoceptors in rabbit by tissue segment binding method.

Horinouchi T1, Morishima S, Tanaka Y, Koike K, Miwa S, Muramatsu I.
Life sciences.Life Sci.2009 Jan 30;84(5-6):181-7. doi: 10.1016/j.lfs.2008.11.016. Epub 2008 Dec 3.
AIMS: This study evaluates ocular (iris, ciliary body and ciliary process) and nonocular (atria and lung) beta-adrenoceptors in rabbit to characterize the plasma membrane beta-adrenoceptors and binding affinities of beta-adrenoceptor antagonists.MAIN METHODS: The tissue segment binding method with a
PMID 19087880

Allergic contact dermatitis due to levobunolol with cross-sensitivity to befunolol.

Nino M1, Balato A, Ayala F, Balato N.
Contact dermatitis.Contact Dermatitis.2007 Jan;56(1):53-4.
PMID 17177718

Japanese Journal

Contact dermatitis due to nipradilol ophthalmic solution

Environmental dermatology : the official journal of the Japanese Society for Contact Dermatitis 9(4), 164-167, 2002-10-01
NAID 50000745315

ウサギ瞳孔括約筋におけるβ-アドレナリン受容体の立体選択性に関する研究

眼薬理 = Japanese journal of ocular pharmacology 16(1), 29-35, 2002-08-30
NAID 10013917191

ウサギ瞳孔括約筋におけるβ-アドレナリン受容体の立体選択性に関する研究

あたらしい眼科 = Journal of the eye 19(1), 99-105, 2002-01-30
NAID 10017003215

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★リンクテーブル★

リンク元	「ベフノロール」
拡張検索	「befunolol hydrochloride」

「ベフノロール」

Befunolol
Systematic (IUPAC) name
	(RS)-1-{7-[2-hydroxy-3-(propan-2-ylamino)propoxy]- 1-benzofuran-2-yl}ethanone
Clinical data
Trade names	Benfuran, Bentos, Betaclar, Glauconex
AHFS/Drugs.com	International Drug Names
Identifiers
CAS Number	39552-01-7
ATC code	S01ED06 (WHO)
PubChem	CID 2309
DrugBank	DB09013
ChemSpider	2219
UNII	418546MT3A
KEGG	D07496
ChEMBL	CHEMBL153984
Chemical data
Formula	C16H21NO4
Molar mass	291.342 g/mol
	SMILES O=C(c2oc1c(OCC(O)CNC(C)C)cccc1c2)C ;
	InChI InChI=1S/C16H21NO4/c1-10(2)17-8-13(19)9-20-14-6-4-5-12-7-15(11(3)18)21-16(12)14/h4-7,10,13,17,19H,8-9H2,1-3H3 ; Key:ZPQPDBIHYCBNIG-UHFFFAOYSA-N ;
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