塩基対置換

WordNet

any of various water-soluble compounds capable of turning litmus blue and reacting with an acid to form a salt and water; "bases include oxides and hydroxides of metals and ammonia" (同)alkali
(numeration system) the positive integer that is equivalent to one in the next higher counting place; "10 is the radix of the decimal system" (同)radix
the bottom side of a geometric figure from which the altitude can be constructed; "the base of the triangle"
situate as a center of operations; "we will base this project in the new lab"
a place that the runner must touch before scoring; "he scrambled to get back to the bag" (同)bag
installation from which a military force initiates operations; "the attack wiped out our forward bases" (同)base of operations
a support or foundation; "the base of the lamp" (同)pedestal, stand
(electronics) the part of a transistor that separates the emitter from the collector
a flat bottom on which something is intended to sit; "a tub should sit on its own base"
the principal ingredient of a mixture; "glycerinated gelatin is used as a base for many ointments"; "he told the painter that he wanted a yellow base with just a hint of green"; "everything she cooked seemed to have rice as the base"
the place where you are stationed and from which missions start and end (同)home
(anatomy) the part of an organ nearest its point of attachment; "the base of the skull"
the bottom or lowest part; "the base of the mountain"
illegitimate (同)baseborn
of low birth or station (`base is archaic in this sense); "baseborn wretches with dirty faces"; "of humble (or lowly) birth" (同)baseborn, humble, lowly
not adhering to ethical or moral principles; "base and unpatriotic motives"; "a base, degrading way of life"; "cheating is dishonorable"; "they considered colonialism immoral"; "unethical practices in handling public funds" (同)immoral
having or showing an ignoble lack of honor or morality; "that liberal obedience without which your army would be a base rabble"- Edmund Burke; "taking a mean advantage"; "chokd with ambition of the meaner sort"- Shakespeare; "something essentially vulgar and meanspirited in politics" (同)mean, meanspirited
(used of metals) consisting of or alloyed with inferior metal; "base coins of aluminum"; "a base metal"
debased; not genuine; "an attempt to eliminate the base coinage"
form a pair or pairs; "The two old friends paired off" (同)pair off, partner off, couple
a set of two similar things considered as a unit (同)brace
a poker hand with 2 cards of the same value
two people considered as a unit
arrange in pairs; "Pair these numbers" (同)geminate
occur in pairs (同)geminate
the act of putting one thing or person in the place of another: "he sent Smith in for Jones but the substitution came too late to help" (同)exchange, commutation
an event in which one thing is substituted for another; "the replacement of lost blood by a transfusion of donor blood" (同)permutation, transposition, replacement, switch
having a base; "firmly based ice"
having a base of operations (often used as a combining form); "a locally based business"; "an Atlanta-based company"; "carrier-based planes"
the act of grouping things or people in pairs

PrepTutorEJDIC

《文》(人や人の行動・孝えが)『卑しい』,下劣な / (金属が)質の劣った;(貨幣が)粗悪な
『基礎』,根拠 / 『基部』,基底,土台 / 『根拠地』,基地 / (野球の)塁,ベース / 主成分;塩基(酸と反応シテ塩(官)を生じる化合物) / (数学で図形の)底;底辺;基線 / (…に)…‘の'『基礎をおく』《+『名』+『on』(『upon』)+『名』》
(二つで一つに用いられる物の)『組』,『対』《+『of』+『名』》 / (対になる部分からなる物の)『1個』《+『of』+『名』》 / 《集合的に》《複数扱い》夫婦,婚約中の男女;(動物の)つがい《+『of』+『名』》 / 《集合的に》《複数扱い》(同種または何かの関係のある物の)二人(二つ,2頭など)の組《+『of』+『名』》 / …‘を'二人(2個)ずつ組にする《+『名』+『off』(『up』),+『off』(『up』)+『名』》,(…と)…‘を'組にする《+『名』+『with』+『名』》 / (…と)…‘を'結婚させる《+『名』+[『up』]『with』+『名』》 / 二人(2個)ずつ組になる《+『off』(『up』)》
(…の)『代用』,代理,置き換え《+for+名》

UpToDate Contents

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1. 胎児の酸塩基の生理学 fetal acid base physiology
2. 臍帯血酸塩基分析 umbilical cord blood acid base analysis
3. 単純性および混合性酸塩基障害 simple and mixed acid base disorders
4. 酸塩基障害におけるカリウムバランス potassium balance in acid base disorders
5. マウス遺伝子：育種戦略と遺伝子工学 mouse genetics breeding strategies and genetic engineering

English Journal

[Autoimmune lymphoproliferative syndrome: a case report and literature review].

Sun JP1, Lu XT1, Zhao WH1, Hua Y1.
Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences.Beijing Da Xue Xue Bao.2015 Dec 18;47(6):1022-7.
We described 1 case of autoimmune lymphoproliferative syndrome (ALPS), first diagnosed in our hospital, and reviewed the recent literature. The 11-month old male patient presented with a history of splenomegaly and hepatomegaly since 1 month after birth. He suffered recurrent infectious diseases inc
PMID 26679669

Abasic pivot substitution harnesses target specificity of RNA interference.

Lee HS1, Seok H1, Lee DH2, Ham J2, Lee W1, Youm EM2, Yoo JS2, Lee YS3, Jang ES2,3, Chi SW1,2,4.
Nature communications.Nat Commun.2015 Dec 18;6:10154. doi: 10.1038/ncomms10154.
Gene silencing via RNA interference inadvertently represses hundreds of off-target transcripts. Because small interfering RNAs (siRNAs) can function as microRNAs, avoiding miRNA-like off-target repression is a major challenge. Functional miRNA-target interactions are known to pre-require transitiona
PMID 26679372

Structural implications of homo-pyrimidine base pairs in the parallel-stranded d(YGA) motif.

Tripathi S1, Paukstelis PJ2.
Chembiochem : a European journal of chemical biology.Chembiochem.2015 Dec 2. doi: 10.1002/cbic.201500491. [Epub ahead of print]
DNA can adopt many other structures beyond the canonical B-form double helix. There has been a growing interest in using non-canonical base pairs to provide structural diversity for designing DNA architectures for nanotechnology applications. We recently described the crystal structure of d(ACTCGGAT
PMID 26629965

Japanese Journal

Imatinib Responsiveness in Canine Mast Cell Tumors Carrying Novel Mutations of c-KIT Exon 11

NAKANO Yuko,KOBAYASHI Tetsuya,OSHIMA Fukiko,FUKAZAWA Eri,YAMAGAMI Tetsushi,SHIRAISHI Yozo,TAKANOSU Masamine
Journal of Veterinary Medical Science, 2013
… In 2 individual cases of canine mast cell tumors, we identified 2 novel c-KIT mutations in exon 11: a 9-base pair (bp) deletion (c.1663-1671del) and a point mutation (c.1676T>A). … The 9-bp deletion mutation caused a loss of 3 amino acids, corresponding to p.Gln555_Lys557del, and the point mutation resulted in the substitution of valine by aspartic acid (p.Val559Asp) in the juxtamembrane domain of the protein. …
NAID 130003382396

Isolation and Molecular Characterization of Catalase-Negative Staphylococcus aureus from Sputum of a Patient with Aspiration Pneumonia

Horiuchi Kazuki,Matsumoto Takehisa,Hidaka Eiko [他],Kasuga Eriko,Sugano Mitsutoshi,Oana Kozue,Kawakami Yoshiyuki,Honda Takayuki
Japanese Journal of Infectious Diseases 65(5), 439-441, 2012
… aureus SH3064, an A217T substitution leading to a threonine 73-to-serine substitution and a single-base pair deletion (c.637delG) resulting in a frameshift mutation. …
NAID 130001931857

Mutagenic potentials of Amberlite XAD-2-resin extracts obtained from river and drinking waters in the Northwest district of Chiba, Japan

Kanno Ayako,Nishi Iwaki,Kishi Tomohiro [他],KAWAKAMI Tsuyoshi,TAKAHASHI Yasuo,ONODERA Sukeo
Journal of toxicological sciences 35(6), 817-826, 2010-12-01
… While the drinking water extracts exhibited weak mutagenicity in both the TA98 and TA100 strains (a base-pair substitution mutagen) without S9 mix, with high mutagenic responses in fall and early winter seasons. …
NAID 10026962935