同: BTK

WordNet

put to bed; "The children were bedded at ten oclock"
a foundation of earth or rock supporting a road or railroad track; "the track bed had washed away"
a piece of furniture that provides a place to sleep; "he sat on the edge of the bed"; "the room had only a bed and chair"
a plot of ground in which plants are growing; "the gardener planted a bed of roses"
the flat surface of a printing press on which the type form is laid in the last stage of producing a newspaper or magazine or book etc.
a depression forming the ground under a body of water; "he searched for treasure on the ocean bed" (同)bottom
(geology) a stratum of rock (especially sedimentary rock); "they found a bed of sandstone"
furnish with a bed; "The inn keeper could bed all the new arrivals"
place (plants) in a prepared bed of soil
small room in which a monk or nun lives (同)cubicle
a device that delivers an electric current as the result of a chemical reaction (同)electric cell
a room where a prisoner is kept (同)jail cell, prison cell
(biology) the basic structural and functional unit of all organisms; they may exist as independent units of life (as in monads) or may form colonies or tissues as in higher plants and animals
any small compartment; "the cells of a honeycomb"
a small unit serving as part of or as the nucleus of a larger political movement (同)cadre
the 2nd letter of the Roman alphabet (同)b
the blood group whose red cells carry the B antigen (同)type_B, group B
an enzyme that catalyzes the conversion of a proenzyme to an active enzyme
an amino acid found in most proteins; a precursor of several hormones

PrepTutorEJDIC

〈C〉〈U〉『ベット』,『寝台』 / 〈U〉睡眠,宿泊 / 〈C〉『花壇,苗床…』養殖場 / 〈C〉(海・川などの)『床』,水底 / 〈C〉地層;(一般に)土台 / …‘に'寝床を与える / 〈子供など〉'を'寝かしつける / 《古》寝る,床につく
(刑務所の)『独房』;(修道院の)小さい独居室 / (ミツバチの)みつ房,巣穴 / 小さい部屋 / 『細胞』 / 電池 / 花粉室 / (共産党などの)細胞

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. BおよびTリンパ球の正常な発生normal b and t lymphocyte development [show details]
… CD79a CD79b ; Bruton tyrosine kinase (BTK) B cell linker protein (BLNK) These disorders are discussed separately. The requirement of BTK for the survival of mature B cells led to development of BTK …
2. B細胞性急性リンパ性白血病/リンパ腫の臨床症状、病理学的特徴、診断clinical manifestations pathologic features and diagnosis of b cell acute lymphoblastic leukemia lymphoma [show details]
… near-diploid (44 to 46); As examples, near-haploid B cell ALL often has RAS or receptor tyrosine kinase mutations, while most low hypodiploid B cell ALL have loss-of-function mutations of TP53 and/or RB1 …
3. 原発性免疫不全症の診断のためのフローサイトメトリーflow cytometry for the diagnosis of primary immunodeficiencies [show details]
…Bruton tyrosine kinase (BTK) gene, leading to a developmental block at the pre-B cell stage of B cell development in the bone marrow that results in near complete deficiency of all mature B cells. B cell …
4. 生物学的療法により誘発された二次性免疫不全症secondary immunodeficiency induced by biologic therapies [show details]
… include ibrutinib, which inhibits Bruton tyrosine kinase, and the Janus kinase inhibitors, tofacitinib and ruxolitinib. Ibrutinib inhibits B cell activation and B cell-mediated signaling and can cause neutropenia …
5. 造血腫瘍の分類classification of hematopoietic neoplasms [show details]
… ("Transformations of indolent B cell lymphomas," "Primary large B cell lymphoma of immune-privileged sites") and a category of tumors and tumor-like lesions with B cell predominance ("Lymphoid… Myeloid/lymphoid neoplasms with eosinophilia and tyrosine kinase gene fusions – Mastocytosis – Histiocytic/dendritic…

English Journal

Development and validation of an UHPLC-MS/MS method for simultaneous quantification of ibrutinib and its dihydrodiol-metabolite in human cerebrospinal fluid.

Beauvais D1, Goossens JF2, Boyle E3, Allal B4, Lafont T4, Chatelut E4, Herbaux C3, Morschhauser F1, Genay S5, Odou P5, Danel C6.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.J Chromatogr B Analyt Technol Biomed Life Sci.2018 Sep 1;1093-1094:158-166. doi: 10.1016/j.jchromb.2018.06.026. Epub 2018 Jun 15.
PMID 30029202

Ibrutinib as Treatment for Patients With Relapsed/Refractory Follicular Lymphoma: Results From the Open-Label, Multicenter, Phase II DAWN Study.

Gopal AK1, Schuster SJ1, Fowler NH1, Trotman J1, Hess G1, Hou JZ1, Yacoub A1, Lill M1, Martin P1, Vitolo U1, Spencer A1, Radford J1, Jurczak W1, Morton J1, Caballero D1, Deshpande S1, Gartenberg GJ1, Wang SS1, Damle RN1, Schaffer M1, Balasubramanian S1, Vermeulen J1, Cheson BD1, Salles G1.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology.J Clin Oncol.2018 Aug 10;36(23):2405-2412. doi: 10.1200/JCO.2017.76.8853. Epub 2018 May 31.
PMID 29851546

The BTK Inhibitor ARQ 531 Targets Ibrutinib Resistant CLL and Richter's Transformation.

Reiff SD1, Mantel R1, Smith LL1, Greene JT1, Muhowski EM1, Fabian CA2, Goettl VM3, Tran M4, Harrington B5, Rogers KA1, Awan FT6, Maddocks K7, Andritsos L6, Lehman AM8, Sampath D3, Lapalombella R3, Eathiraj S9, Abbadessa G10, Schwartz B11, Johnson A1, Byrd JC3, Woyach JA12.
Cancer discovery.Cancer Discov.2018 Aug 9. pii: CD-17-1409. doi: 10.1158/2159-8290.CD-17-1409. [Epub ahead of print]
PMID 30093506

Related Pictures

Frontiers | Targeting Bruton’s Tyrosine Kinase in CLL Ibrutinib: A comprehensive review of a promising drug Kapoor A, Singh P, Beniwal S Bruton's Tyrosine Kinase: An Exciting New Target for Treatment of B-Cell Malignancies Schematic representation of mechanism of action of tyrosine kinase tyrosine kinase receptor | insulin receptor receptor tyrosine kinase Stages of B cell differentiation and associated malignancies. Model of Schematic model showing Bruton’s tyrosine kinase (Btk) regulation by | Download TYROSINE KINASE | Tyrosine, Cell membrane, Ap biology