アズール好性顆粒
WordNet
- a tiny grain
PrepTutorEJDIC
- 小粒,微粒
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/02/11 19:02:12」(JST)
[Wiki en表示]
| Azurophilic granule |
| Details |
| Latin |
granulum azurophilum |
| Identifiers |
| Code |
TH H2.00.04.1.02011
TH H2.00.04.1.02014 |
| Anatomical terminology |
An azurophil is an object readily stained with an azure stain. In white blood cells and hyperchromatin, imparting a burgundy or merlot coloration. Neutrophils in particular are known for containing azurophils loaded with a wide variety of anti-microbial defensins that fuse with phagocytic vacuoles. Azurophils may contain myeloperoxidase, phospholipase A2, Acid Hydrolases, Elastase, defensins, neutral serine proteases, bactericidal/permeability-increasing protein,[1] lysozyme, cathepsin G, proteinase 3, and proteoglycans.
Azurophil granules are also known as "primary granules".[2]
Furthermore, the term Azurophils may refer to a unique type of cells, identified only in reptiles. These cells are similar in size to so-called heterophils with abundant cytoplasm that is finely to coarsely granular and may sometimes contain vacuoles. Granules may impart a purplish hue to the cytoplasm, particularly to the outer region. Occasionally azurophils are observed with vacuolated cytoplasm.[3]
See also
- Azure A
- azure (color)
- lysosome
- specific granules
References
- ^ "Phagocytes-Neutrophils".
- ^ John P. Greer; Maxwell Myer Wintrobe (1 December 2008). Wintrobe's clinical hematology. Lippincott Williams & Wilkins. p. 173. ISBN 978-0-7817-6507-7. Retrieved 10 November 2010.
- ^ Bonnie Ballard; Ryan Cheek (May 4, 2010). Exotic Animal Medicine for the Veterinary Technician (2 ed.). Wiley-Blackwell. p. 391. ISBN 978-0813822068.
External links
|
Antimicrobial peptides: Granulocyte granule contents
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| Azurophilic granules (1°) |
- Myeloperoxidase
- Defensins
- neutral serine proteases (Proteinase 3)
- Lysozyme
- Bactericidal/permeability increasing protein
- Collagenase
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| Specific granules (2°) |
|
Neutrophil
|
- Alkaline phosphatase
- Lactoferrin
- Lysozyme
- NADPH oxidase
- Collagenase
- Cathelicidin
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Eosinophil
|
- Cathepsin
- Major basic protein
- Eosinophil cationic protein
- Eosinophil peroxidase
- Eosinophil-derived neurotoxin
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Basophil
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see also platelet alpha-granule, dense granule
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Index of cells from bone marrow
|
|
| Description |
- Immune system
- Cells
- Physiology
- coagulation
- proteins
- granule contents
- colony-stimulating
|
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| Disease |
- Red blood cell
- Monocyte and granulocyte
- Neoplasms and cancer
- Histiocytosis
- Symptoms and signs
- Blood tests
|
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| Treatment |
- Transfusion
- Drugs
- antithrombotics
- antihemorrhagics
- other
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UpToDate Contents
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English Journal
- α-1-antitrypsin variants and the proteinase/antiproteinase imbalance in chronic obstructive pulmonary disease.
- Sinden NJ, Baker MJ, Smith DJ, Kreft JU, Dafforn TR, Stockley RA.
- American journal of physiology. Lung cellular and molecular physiology.Am J Physiol Lung Cell Mol Physiol.2015 Jan 15;308(2):L179-90.
- The excessive activities of the serine proteinases neutrophil elastase and proteinase 3 are associated with tissue damage in chronic obstructive pulmonary disease. Reduced concentrations and/or inhibitory efficiency of the main circulating serine proteinase inhibitor α-1-antitrypsin result from poi
- PMID 25416382
- Human α-defensin expression is not dependent on CCAAT/enhancer binding protein-ε in a murine model.
- Glenthøj A1, Dahl S1, Larsen MT1, Cowland JB1, Borregaard N1.
- PloS one.PLoS One.2014 Mar 21;9(3):e92471. doi: 10.1371/journal.pone.0092471. eCollection 2014.
- Specific granule deficiency (SGD) is a rare congenital disorder characterized by recurrent infections. The disease is caused by inactivating mutations of the CCAAT/enhancer binding protein-ε (C/EBP-ε) gene. As a consequence, specific and gelatinase granules lack most matrix proteins. Furthermore,
- PMID 24658030
- Proteome profiling of human neutrophil granule subsets, secretory vesicles, and cell membrane: correlation with transcriptome profiling of neutrophil precursors.
- Rørvig S1, Østergaard O, Heegaard NH, Borregaard N.
- Journal of leukocyte biology.J Leukoc Biol.2013 Oct;94(4):711-21. doi: 10.1189/jlb.1212619. Epub 2013 May 6.
- Neutrophils are indispensable in the innate immune defense against invading microorganisms. Neutrophils contain SVs and several subsets of granules that are essential for their function. Proteins present in neutrophil SVs and granules are synthesized during terminal granulopoiesis in the bone marrow
- PMID 23650620
Japanese Journal
- Effect of different dialyzers on defensins during hemodialysis
- 好中球の殺菌性ペプチドＣＡＰ１１とデフェンシンの生物活性と遺伝子発現の比較
- Antifungal Mechanisms of Leukocytes
Related Links
- granule /gran·ule/ (gran´ūl) 1. a small particle or grain. 2. a small pill made from sucrose. acidophil granules granules staining with acid dyes. acrosomal granule a large globule contained within a membrane-bounded acrosomal ...
- 1. any granule that stains easily with azure dyes. See also azurophilia. 2. a specific type of azurophilic granule found in the promyelocyte; it contains numerous compounds that are antimicrobial, including myeloperoxidase. Called ...
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